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  4. Recombinant Sendai virus Protein C' (P/V/C)

Recombinant Sendai virus Protein C' (P/V/C)

  • 货号：
    CSB-YP528787SYH
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP528787SYH
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP528787SYH-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP528787SYH
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP528787SYH
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    P/V/C
  • Uniprot No.：
  • 别名：
    P/V/CProtein C'
  • 种属：
    Sendai virus (strain Ohita) (SeV)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-215
  • 氨基酸序列
    ASATLPAWI KMPSFLKKIL KLRGRRQEDE SRSRMLSDSS TQSYQVNQLT SEGTEAGSTI PSTPSKGQAL PTESKVRARE KSRHRRPKII DQVRRVESLG EQASQRQKHM LETLINKIYT GPLGEELVQT LYLRIWAMEE TPESLKILQM REDIRDQVLK MKTERWLRTL IRGEKTKLKD FQKRYEEVHP YLMKEKVEQI IMEEAWSLAA HIVQE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    The different products prevent the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. They inhibit IFN-alpha/beta induced tyrosine phosphorylation of STAT1 and STAT2. Blocking the IFN-alpha/beta pathway requires binding to STAT1 in the cytoplasm. They inhibit IFN-gamma induced serine phosphorylation of STAT1. Block the IFN-gamma pathway by binding to and stabilizing the parallel form of the STAT1 dimer, further inducing high-molecular-weight complex formation and inhibition of transcription by IFN-gamma. May also have a role in preventing the cell to enter apoptosis. Modulate regulation of viral transcription and replication. Overexpression inhibits the viral RNA polymerase. The absence of all C', C and Y1 proteins leads to viral delayed growth. Plays an important role in virion particles release. Modulates virion shape.
  • 基因功能参考文献：
    1. The s found that in Sendai virus C protein deletion mutant-infected cells, Sendai virus defective interfering RNA also functioned as an exclusive RIG-I ligand. PMID: 28631605
    2. This is the first structural report of the C protein, suggesting a mechanism of evasion of the paramyxovirus from innate immunity. PMID: 26339056
    3. Data indicate the ability of C protein to block Toll-like receptor (TLR) 7- and TLR9-dependent IFN-alpha induction. PMID: 24269682
    4. These results suggest that the C protein play important roles in viral escape from induction of IFN-beta and cell death triggered by infection. PMID: 20502666
    5. innate immunity contributed to elimination of SeV in early stages of infection in the absence of anti-IFN capacity PMID: 17215288
    6. intracellular localization of the C protein at the plasma membrane is essential for inducing the interferon-independent phosphorylation of Stat1 as part of the viral program to prevent the cellular antiviral response PMID: 17229713
    7. Our results demonstrate for the first time that the C proteins regulate balance of viral genome and antigenome RNA synthesis for efficient production of infectious virus particles in the course of virus infection. PMID: 18252261
    8. Results demonstrate that the Sendai virus C protein limits generation of double stranded RNA, thereby keeping protein kinase R inactive to maintain intracellular protein synthesis. PMID: 18684815

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  • 亚细胞定位：
    Host cytoplasm.
  • 蛋白家族：
    Respirovirus protein C family
  • 数据库链接：

    KEGG: vg:1489773