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  4. Recombinant Sex determination protein fox-1 (fox-1)

Recombinant Sex determination protein fox-1 (fox-1)

  • 货号：
    CSB-YP606006CXY
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP606006CXY
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP606006CXY-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP606006CXY
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP606006CXY
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    fox-1
  • Uniprot No.：
  • 别名：
    fox-1; T07D1.4Sex determination protein fox-1; Feminizing locus on X protein 1
  • 种属：
    Caenorhabditis elegans
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-415
  • 氨基酸序列
    MQALYQLSAT GAQQQNQQIP IGLSNSLLYQ QLAAHQQIAA QQHQQQLAVS AAHQTQNNIM LATSAPSLIN HMENSTDGKV KDDPNSDYDL QLSIQQQLAA AAQAAQMGQT QIGPQIVGQQ GQPVVATTAG STNGSAAVTQ PDPSTSSGPD GPKRLHVSNI PFRFRDPDLK TMFEKFGVVS DVEIIFNERG SKGFGFVTME RPQDAERARQ ELHGSMIEGR KIEVNCATAR VHSKKVKPTG GILDQMNPLM AQSALAAQAQ MNRALLLRSP LVAQSLLGRG AALIPGMQQP AFQLQAALAG NPLAQLQGQP LLFNAAALQT NALQQSAFGM DPAAVQAALL ANEQARFQLA AAAAQGNEYI MYHQAKQQEL PGRIPSSGNA SAFGEQYLSN ALATASLPSY QMNPALRTLN RFTPY
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    RNA-binding protein that regulates tissue-specific alternative splicing events by binding to 5'-UGCAUG-3' and 5'-GCACG-3' elements. Also binds to poly(A), poly(G), poly(C), or poly(U) stretches of RNA. Plays a role in the sex determination pathway and X chromosome dosage compensation, and together with sex-1 is involved in making the distinction between one and two X-chromosomes. Binds to 5'-GCAUG-3' and 5'-GCACG-3' elements in intron 6 of the pre-mRNA of the sex-determining factor xol-1 to promote its alternative splicing and together with sex-1 negatively regulates the expression of xol-1 to promote hermaphrodite development. Negatively regulates the expression of the active isoform of xol-1 (isoform b) by promoting intron 6 retention and the deletion of exon 7 coding sequences in hermaphrodite embryos. Furthermore, binding to the pre-mRNA of xol-1 can also direct the use of an alternative 3' splice site enabling the xol-1 transcript to be trans-spliced to unrelated genes on chromosome 2, which also leads to xol-1 exon 7 deletion. Does not seem to regulate the retention of introns 1 to 5 of xol-1 pre-mRNA. Plays a role in the association of the dosage compensation complex proteins dpy-27 and sdc-3 with the hermaphrodite X chromosomes. Binds to 5'-UGCAUG-3' elements in intron 7 of the pre-mRNA of unc-32 to promote its alternative splicing in neuronal tissues. Binds to 5'-UGCAUG-3' elements in intron 4 of the pre-mRNA of egl-15 to promote its alternative splicing in body wall muscle tissues. Promotes binding of RNA-binding protein sup-12 to target RNA. Plays a role in male mating behavior.
  • 基因功能参考文献：
    1. SUP-12, coregulates the egl-15 alternative splicing. PMID: 17923701
  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    In males and hermaphrodites expressed in a subset of cells in the head and tail. Expressed in the pharynx, intestine and in muscles from the vulva and body wall.
  • 数据库链接：

    STRING: 6239.T07D1.4.1