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  4. Recombinant Staphylococcus aureus Zinc metalloproteinase aureolysin (aur)

Recombinant Staphylococcus aureus Zinc metalloproteinase aureolysin (aur)

  • 货号：
    CSB-YP305800FKZ
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP305800FKZ-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP305800FKZ
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP305800FKZ
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    aur
  • Uniprot No.：
  • 别名：
    aur; Zinc metalloproteinase aureolysin; EC 3.4.24.29; Staphylococcus aureus neutral proteinase
  • 种属：
    Staphylococcus aureus
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    210-509
  • 氨基酸序列
    A ATGTGKGVLG DTKDININSI DGGFSLEDLT HQGKLSAYNF NDQTGQATLI TNEDENFVKD DQRAGVDANY YAKQTYDYYK NTFGRESYDN HGSPIVSLTH VNHYGGQDNR NNAAWIGDKM IYGDGDGRTF TNLSGANDVV AHELTHGVTQ ETANLEYKDQ SGALNESFSD VFGYFVDDED FLMGEDVYTP GKEGDALRSM SNPEQFGQPS HMKDYVYTEK DNGGVHTNSG IPNKAAYNVI QAIGKSKSEQ IYYRALTEYL TSNSNFKDCK DALYQAAKDL YDEQTAEQVY EAWNEVGVE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 产品描述：
    Recombinant Staphylococcus aureus Zinc metalloproteinase aureolysin(aur) is a partial length protein expressed with an N-terminal His-tagged or Tag-Free. Its expression region corresponds to 210-509aa of mouse aur protein. Its purity was determined by SDS-PAGE and reached up to 85%. This recombinant aur protein may be used to synthesize antibodies against aur or on the studies of aur-associated signal transduction.
    Aureolysin is an extracellular zinc-dependent metalloproteinase expressed by the pathogenic bacterium Staphylococcus aureus. This enzyme can cleave host factors of the innate immune system anf regulae S. aureus secreted toxins and cell wall proteins, resulting in the bacterium's virulence or disease. To catalyze its enzymatic activities, aureolysin requires zinc and calcium which it obtains from the extracellular environment within the host.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays an essential role in immune evasion by helping bacteria to resist complement-mediated killing by neutrophils. Inhibits the deposition of host C3b on bacterial surfaces and the release of the chemoattractant C5a by cleaving the central complement protein C3. The cleavage site renders the C3b molecule vulnerable to proteolytic degradation by host regulators. Cleaves and inactivates host SERPINA1, which is an endogenous protease inhibitor essential for controlling neutrophil serine protease elastase. Plays also an essential role in the cleavage and subsequent activation of the serine protease SspA which is involved in colonization and infection of human tissues.
  • 蛋白家族：
    Peptidase M4 family