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  4. Recombinant Superoxide dismutase [Cu-Zn] (sod-1)

Recombinant Superoxide dismutase [Cu-Zn] (sod-1)

  • 货号：
    CSB-YP022397CXY
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP022397CXY
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP022397CXY-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP022397CXY
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP022397CXY
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    sod-1
  • Uniprot No.：
  • 别名：
    sod-1; C15F1.7; Superoxide dismutase [Cu-Zn]; EC 1.15.1.1
  • 种属：
    Caenorhabditis elegans
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    20-180
  • 氨基酸序列
    A QKMSNRAVAV LRGETVTGTI WITQKSENDQ AVIEGEIKGL TPGLHGFHVH QYGDSTNGCI SAGPHFNPFG KTHGGPKSEI RHVGDLGNVE AGADGVAKIK LTDTLVTLYG PNTVVGRSMV VHAGQDDLGE GVGDKAEESK KTGNAGARAA CGVIALAAPQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Required for normal brood size. May be involved in regulating mpk-1 phosphorylation downstream of phosphatase ptp-2 during oocyte maturation.
  • 基因功能参考文献：
    1. We found that guanylyl cyclases GCY-5 and GCY-22 and neuropeptide receptor NPR-1 act antagonistically to regulate SOD-1 expression in the gustatory neuron ASER. PMID: 29857312
    2. These data suggest that SOD1 mutants are removed from the nucleus by CRM1 as a defense mechanism against proteotoxicity of misfolded SOD1 in the nucleus. PMID: 28463106
    3. a post-translational modification to the inactive enzyme during hypoxia PMID: 22148750
    4. SOD isoforms play no role in lifespan in ad lib or dietary restricted conditions, but mutational inactivation of SOD-1 reduces life extension by cold. PMID: 19059428
    5. the ALS-linked mutant SOD1 produces a locomotor defect associated with aggregation and synaptic dysfunction when expressed in neurons of Caenorhabditis elegans PMID: 19165329
    6. this suggests that the activity of SOD-1, which so far has been thought to act mainly in cytoplasm, helps to control the detoxification of *O2- also in the mitochondria. PMID: 19282511

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Cu-Zn superoxide dismutase family
  • 数据库链接：

    KEGG: cel:CELE_C15F1.7

    STRING: 6239.C15F1.7a

    UniGene: Cel.19756