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  4. Recombinant T-box protein 2 (tbx-2)

Recombinant T-box protein 2 (tbx-2)

  • 货号：
    CSB-YP613903CXY
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP613903CXY
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP613903CXY-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP613903CXY
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP613903CXY
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    tbx-2
  • Uniprot No.：
  • 别名：
    tbx-2; F21H11.3; T-box protein 2
  • 种属：
    Caenorhabditis elegans
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-423
  • 氨基酸序列
    MAFNPFALGR PDLLLPFMGA GVGGPGAGGP PPNLFFSMLQ AGFPPGPVGS PPEDDGVTDD PKVELDEREL WQQFSQCGTE MVITKSGRRI FPAYRVKISG LDKKSQYFVM MDLVPADEHR YKFNNSRWMI AGKADPEMPK TLYIHPDSPS TGEHWMSKGA NFHKLKLTNN ISDKHGYTIL NSMHKYQPRL HVVRCADRHN LMYSTFRTFV FRETEFIAVT AYQNEKVTEL KIENNPFAKG FRDAGAGKRE KKRQLHRMNG DATQSPPGKT ASLPTHSPHP SESNSEDDEP TLKKCKPEPS QTPTTSSLST STTPTLSAHH PLRSPQFCIP PPIDMMYQNM PMDLLAHWQM ATLFPQFSMA LNSPAAAASL LSKHLAKASS ECKVEATSED SEEAEKPEVK KEQKSVTPPK KGGFDVLDLL SKP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in the transcriptional regulation of genes required for the development of pharyngeal muscles derived from the ABa lineage. Acts as a transcriptional repressor and binds to T-box binding sites in its own promoter to negatively autoregulate its own expression in neurons, seam cells and the gut in order to restrict its expression to certain tissues. May function together with the nfya-1-NF-Y complex to repress its own expression.
  • 基因功能参考文献：
    1. Reduction of SUMOylation enhances the effect of a tbx-2 hypomorphic mutant on embryonic viability and pharyngeal muscle development, and that repression of a downstream target of TBX-2 depends on SUMOylation. PMID: 23595631
    2. Ce-TBX-2, the TBX2/TBX3 transcriptional factor homologue of the nematode Caenorhabditis elegans, is involved in olfactory adaptation PMID: 14750151
    3. TBX-2 and SUMO-conjugating enzymes are necessary for ABa-derived pharyngeal muscle, and we hypothesize that TBX-2 function requires sumoylation. PMID: 16701625
    4. The analysis suggests that a positive feedback loop between tbx-2 and pha-4 is required for blastomere-derived precursors to commit to pharyngeal muscle fate. PMID: 17005176
    5. In screens for mutants with abnormal HSN motor neuron development, we identified the T-box protein TBX-2 as being important for both HSN and PHB sensory neuron differentiation. PMID: 18505863

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in body wall muscles and a subset of pharyngeal neurons. Expressed in head neurons and occassionally tail neurons. Not expressed in the pharynx.
  • 数据库链接：

    KEGG: cel:CELE_F21H11.3

    STRING: 6239.F21H11.3

    UniGene: Cel.8043