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  4. Recombinant Tityus serrulatus Potassium channel toxin TsTXK-beta

Recombinant Tityus serrulatus Potassium channel toxin TsTXK-beta

  • 货号：
    CSB-YP303208TON
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP303208TON
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP303208TON-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP303208TON
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP303208TON
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    N/A
  • Uniprot No.：
  • 别名：
    ; Potassium channel toxin TsTXK-beta; Potassium channel toxin beta-KTx 1; Tityustoxin K-beta; TsTX K beta; TsTX-K beta; TsTXKbeta; Ts8; TsK2
  • 种属：
    Tityus serrulatus (Brazilian scorpion)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    28-87
  • 氨基酸序列
    KLV ALIPNDQLRS ILKAVVHKVA KTQFGCPAYE GYCNDHCNDI ERKDGECHGF KCKCAKD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Specifically blocks voltage-gated potassium channels Kv4.2/KCND2. When measured at the peak current, the blocking effect of this toxin is about 65% and shows an IC(50)=652 nM. However, when measured at a later moment of the depolarising test pulse (500 ms), a 100% block of the current is observed with an IC(50)=313 nM. This may indicate a preference of the toxin for binding the inactivated state of the channel. The inhibition is completely reversible. Using intraplantar injections on rat, this toxin induces overt nociception (licking and lifting behaviors) and decreases the mechanical nociceptive threshold (hyperalgesia). Furthermore, the hyperalgesia is prolonged when intrathecal injections are performed.
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Long chain scorpion toxin family, Class 1 subfamily
  • 组织特异性：
    Expressed by the venom gland.