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  4. Recombinant WD repeat-containing protein tag-125 (tag-125)

Recombinant WD repeat-containing protein tag-125 (tag-125)

  • 中文名称：
    秀丽隐杆线虫wdr-5.1重组蛋白
  • 货号：
    CSB-YP615043CXY
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    秀丽隐杆线虫wdr-5.1重组蛋白
  • 货号：
    CSB-EP615043CXY
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    秀丽隐杆线虫wdr-5.1重组蛋白
  • 货号：
    CSB-EP615043CXY-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    秀丽隐杆线虫wdr-5.1重组蛋白
  • 货号：
    CSB-BP615043CXY
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    秀丽隐杆线虫wdr-5.1重组蛋白
  • 货号：
    CSB-MP615043CXY
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    wdr-5.1
  • Uniprot No.：
  • 别名：
    wdr-5.1; swd-3.1; tag-125; C14B1.4; WD repeat-containing protein wdr-5.1
  • 种属：
    Caenorhabditis elegans
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-376
  • 氨基酸序列
    MDTSENAASA AEQQPTQQID QLTVPNAPDG GSSAPAPSTS PNSISPSNPT GTPAPGASAQ TPNPNAAGAS ASGSANYKLM CTLEGHTKSI SSAKFSPCGK YLGTSSADKT VKIWNMDHMI CERTLTGHKL GVNDIAWSSD SRCVVSASDD KTLKIFEIVT SRMTKTLKGH NNYVFCCNFN PQSSLVVSGS FDESVRIWDV KTGMCIKTLP AHSDPVSAVS FNRDGSLIAS GSYDGLVRIW DTANGQCIKT LVDDENPPVA FVKFSPNGKY ILASNLDSTL KLWDFSKGKT LKQYTGHENS KYCIFANFSV TGGKWIISGS EDCKIYIWNL QTREIVQCLE GHTQPVLASD CHPVQNIIAS GALEPDNKIH IWRSDV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. Required for di- and trimethylation, particularly for the trimethylation at 'Lys-4' of histone H3. Not required for demethylation of histone H3 'Lys-27'. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, germline establishment, maintenance and function. Implicated in the epigenetic inheritance of lifespan over several generations. Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturated fatty acids. Required for RNA interference with probable antagonistic role against hpl-2 function. Plays a role in vulval cell fate specification by acting in the synthetic multivulva pathway independent of set-2. Sex determining protein required in the germline to promote the spermatogenesis to oogenesis switch during the late larval stages of development. Acts with the sex determining factor tra-1, and redundantly with wdr-5.2, to regulate fog-3 expression, which in turn determines germ cell fate. Cooperates with jmjd-3.1, egl-27 and unc-3 to ensure robust transdifferentiation of the Y rectal cell to the PDA motor neuron during larval development.
  • 基因功能参考文献：
    1. WDR-5.1 associates with the fog-3 promoter and is required for TRA-1 to bind to fog-3 promoter. PMID: 24682813
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    WD repeat WDR5/wds family
  • 组织特异性：
    Enriched in the germline. Detected in all nuclei of the embryo. In larvae, expression is detected in the nuclei of seam cells, somatic gonad precursor cells Z1 and Z4, vulval precursor cells, distal tip cells, hypodermal cells, intestinal and muscle cells
  • 数据库链接：

    KEGG: cel:CELE_C14B1.4

    STRING: 6239.C14B1.4

    UniGene: Cel.22551