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  4. Recombinant Xenopus laevis DAN domain family member 5 (dand5)

Recombinant Xenopus laevis DAN domain family member 5 (dand5)

  • 货号：
    CSB-YP767269XBE
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP767269XBE
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP767269XBE-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP767269XBE
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP767269XBE
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    dand5
  • Uniprot No.：
  • 别名：
    dand5; cerl2; coco; S10-51-B6; DAN domain family member 5; Cerberus-like 2 protein; Cerl-2
  • 种属：
    Xenopus laevis (African clawed frog)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    20-217
  • 氨基酸序列
    F PFMEEEGSAS FAQNVLHSRS FPVSHHGAFM DLPLFRQNRR KISQNFILHS DPREHMDEEA LRRKLVWESA IRRDKMRSQP DQVLPIGQDA LKRSRCHALP FIQNVFRKNC FPVRLPNKFC FGQCNSFYVP GWPAGLSQPC TSCAPSRSRR ISLPLRCRSG HLAWQEVELV EECECETRYD RNTVEPAGSG EDYLPVS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays an important role in regulating the left-right axis by blocking a tgfb1 cascade in the right posterior paraxial mesoderm. Functions as an inhibitor of bmp, tgfb1, nodal, activin and wnt signaling in the ectoderm. May inhibit mesodermal signals, probably through an inhibition of nodal/activin pathways. Seems to regulates cell fate specification and competence before the onset of neural induction. Expression in the entire ectodermal region prior to gastrulation might act to prevent fate specification in the ectoderm and ensure the maintenance of the stem-cell-like properties exhibited by ectodermal cells.
  • 基因功能参考文献：
    1. Coco binds to TGFbeta1 and enhances TGFbeta1 binding to its receptor Alk5 thus acting as both an inhibitor and an enhancer of signaling, depending on the ligand it binds. PMID: 26116664
    2. Coco required to prevent Activin and Nodal signals in dorsal marginal side of embryo from invading the prospective ectoderm, thereby restricting endoderm- and mesoderm-inducing signals to the vegetal and marginal zones of the pre-gastrula Xenopus embryo PMID: 24026124
    3. Coco directly inhibits derriere and Xnr1, and with them define a posttranscriptionally regulated signaling center which is a necessary link in the signaling chain leading to an increased TGF-beta signal on the left side of the embryo. PMID: 17239842
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    DAN family
  • 数据库链接：

    KEGG: xla:594864

    UniGene: Xl.51884