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  4. Recombinant Xenopus laevis Mitogen-activated protein kinase 8 (mapk8)

Recombinant Xenopus laevis Mitogen-activated protein kinase 8 (mapk8)

  • 中文名称：
    有爪蟾蜍mapk8重组蛋白
  • 货号：
    CSB-YP013466XBE
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    有爪蟾蜍mapk8重组蛋白
  • 货号：
    CSB-EP013466XBE
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    有爪蟾蜍mapk8重组蛋白
  • 货号：
    CSB-EP013466XBE-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    有爪蟾蜍mapk8重组蛋白
  • 货号：
    CSB-BP013466XBE
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    有爪蟾蜍mapk8重组蛋白
  • 货号：
    CSB-MP013466XBE
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    mapk8; jnk1; Mitogen-activated protein kinase 8; MAP kinase 8; MAPK 8; EC 2.7.11.24; Stress-activated protein kinase JNK1
  • 种属：
    Xenopus laevis (African clawed frog)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-426
  • 氨基酸序列
    MSRSKRDSNF SVFEIGDSTF TVLKRYQNLK PIGSGAQGIV CAAFDAVLER HVAIKKLSRP FQNQTHAKRA YRELVLMKCV NHKNIIGLLN VFTPQKSLEE FQDLYIVMEL MDANLCQVIQ MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAGTSF MMTPYVVTRY YRAPEVILGM GYKENVDIWS VGCILGEMIK GGVLFPGTDH IDQWNKVIEQ LGTPCTEFMK KLQPTVRTYV ENRPKYAGYS FEKLFPDVLF PADSEHNKLK ASQARDLLSK MLVIDASKRI SVDDALQHPY INVWYDPLEA EAPPPKIPDK QLDEREHTIE EWKELIYKEV LDWEERAKNG VIRGQPAPLG AAVTDGSQAH TSSSSGDASS MSTDPTLPSD TDSSLETSAG TLGCCR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulating transcriptional activity. Regulates morphogenic cell movements, controlling convergent extension during gastrulation. May play a role in the regulation of the circadian clock.
  • 基因功能参考文献：
    1. The results of this study suggest that JNK has a role in the disassembly adherens junctions by means of endocytosis that is required during buccopharyngeal membrane perforation. PMID: 28032936
    2. Hyperosmotic Shock Engages Two Positive Feedback Loops through Caspase-3-dependent Proteolysis of JNK1-2 and Bid. PMID: 26511318
    3. JNK signaling is required to establish microtubule stability and maintain tissue cohesion in the gut. PMID: 23462475
    4. Data show that the death pathway is independent of ERK but relies on activating Bad phosphorylation through the control of both kinases Cdk1 and JNK. PMID: 21858202
  • 亚细胞定位：
    Cytoplasm. Nucleus. Cell junction, synapse.
  • 蛋白家族：
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily
  • 组织特异性：
    Strongly expressed in presumptive ectoderm and mesoderm regions and weakly expressed in endoderm regions during early stages of embryo development. Expressed in the head and dorsal regions during neurula and tailbud stages.
  • 数据库链接：

    KEGG: xla:379876

    UniGene: Xl.8740