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  4. Recombinant Xenopus laevis Pro-opiomelanocortin A (pomc-a)

Recombinant Xenopus laevis Pro-opiomelanocortin A (pomc-a)

  • 货号：
    CSB-YP361771XBE
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP361771XBE
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP361771XBE-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP361771XBE
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP361771XBE
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    pomc-a
  • Uniprot No.：
  • 别名：
    pomc-aPro-opiomelanocortin A; POMC-A; Corticotropin-lipotropin A) [Cleaved into: NPP; Melanotropin gamma; Gamma-MSH); Corticotropin; Adrenocorticotropic hormone; ACTH); Melanocyte-stimulating hormone alpha; Alpha-MSH; Melanotropin alpha); Corticotropin-like intermediary peptide; CLIP); Lipotropin beta; Beta-LPH); Lipotropin gamma; Gamma-LPH); Melanocyte-stimulating hormone beta; Beta-MSH; Melanotropin beta); Beta-endorphin; Met-enkephalin]
  • 种属：
    Xenopus laevis (African clawed frog)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    26-101
  • 氨基酸序列
    QCWES SRCADLSSED GVLECIKACK TDLSAESPVF PGNGHLQPLS ESIRKYVMTH FRWNKFGRRN STGNDGSNTG Y
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Stimulates the adrenal glands to release cortisol.; Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.; Increases the pigmentation of skin by increasing melanin production in melanocytes.; Endogenous orexigenic opiate.; Endogenous opiate.
  • 基因功能参考文献：
    1. DCLK phosphorylation and nuclear translocation stimulate POMC gene expression in endocrine melanotrope cells. PMID: 21447633
    2. Extracellular-signal regulated kinase regulates production of pro-opiomelanocortin in pituitary melanotroph cells. PMID: 21129045
    3. The V-ATPase accessory subunit Ac45 represents the first regulator of the proton pump and controls V-ATPase-mediated granular acidification that is necessary for efficient prohormone processing. PMID: 20702583
    4. In the melanotrope, biosynthesis and processing occur along a secretory granule maturation axis and light controls the biosynthesis and secretion of POMC end-products. PMID: 14962071
    5. Gonadal POMC convertase gene expression is demonstrated in Xenopus laevis. PMID: 15891038
    6. The p24 proteins fulfil their role in secretory protein biosynthesis via COPI- or COPII-coated transport vesicles. PMID: 19401156

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    POMC family
  • 数据库链接：

    KEGG: xla:380532

    UniGene: Xl.18423