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  4. Recombinant Xenopus laevis Protein Wnt-11b (wnt11b)

Recombinant Xenopus laevis Protein Wnt-11b (wnt11b)

  • 货号：
    CSB-YP342646XBE
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP342646XBE
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP342646XBE-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP342646XBE
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP342646XBE
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    wnt11b
  • Uniprot No.：
  • 别名：
    wnt11b; wnt-11; wnt11; Protein Wnt-11b; Protein Wnt-11; XWnt-11
  • 种属：
    Xenopus laevis (African clawed frog)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    23-353
  • 氨基酸序列
    IQWLGLTV NGSRVAWNES EHCRLLDGLV PDQSQLCKRN LELMQSVVNA AKQTKLTCQM TLSDMRWNCS SVENAPSFTP DLSKGTRESA FVYALASATL SHTIARACAS GELPTCSCGA TPAEVPGTGF RWGGCGDNLH YGLNMGSAFV DAPMKSSKSA GTQATKIMNL HNNAVGRQVL MDSLETKCKC HGVSGSCSVK TCWKGLQDLP HIANELKSKY LGATKVIHRQ TGTRRQLVPR ELDIRPVRES ELVYLVSSPD YCTKNPKLGS YGTQDRLCNK TSVGSDSCNL MCCGRGYNAY TETIVERCQC KYHWCCYVMC KKCERTVERY VCK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Ligand for the frizzled7 transmembrane receptor. Primarily acts via non-canonical Wnt pathways mediated by either Ca(2+) and PKC, or by JNK and dvl2/dsh. Depending on the cellular context, can also signal via the canonical Wnt pathway mediated by beta-catenin and dvl2/dsh. May also inhibit canonical Wnt signaling. Maternally initiates dorsal/ventral axis formation by a canonical route, which signals via lrp6. In a complex with wnt5a, activates the canonical and non-canonical processes involved in axis formation. In the non-canonical pathway, acts through fzd7/fz7 to induce phosphorylation of dvl2/dsh. Signals through a non-canonical Wnt pathway to regulate convergent extension movements during gastrulation. Interactions with the secreted Wnt antagonist sfrp5 to coordinate foregut development, acting via a non-canonical Wnt pathway whereby sfrp5 restricts wnt11b activity to prevent inappropriate foregut formation. Mediates cardiogenesis via non-canonical Wnt signaling involving JNK-activation and PKC. Acts redundantly with wnt11/wnt11r during pronephros induction.
  • 基因功能参考文献：
    1. These results indicate that Pcdh7 plays an important role in maintaining the sensorial layer at the lateral neural crest border, which is nec- essary for the secretion of survival factors, including Wnt11b PMID: 29366801
    2. Rcsd1 is required downstream of Wnt11 for ventricular trabeculation, terminal differentiation of cardiomyocytes and cardiac morphogenesis. PMID: 28237811
    3. Sulf1 enhances the ability of Wnt11b to activate canonical and non-canonical Wnt signaling. PMID: 25681501
    4. Wnt11b is involved in cilia-mediated symmetry breakage during Xenopus left-right development. PMID: 24058481
    5. Data show that Wnt11b signaling can rescue reduced cardiac differentiation resulting from loss of function of GATA4 and 6 but not GATA5. PMID: 21305652
    6. a novel regulatory system for Wnts by Secreted Frizzled-related proteins PMID: 19906850
    7. Xwnt-11 mRNA appears in polysomes only at the end of gastrula. PMID: 12946266
    8. Wnt11 is an initiating signal in activatione canonical Wnt signaling. PMID: 15797385
    9. Wnt11 plays an essential role in neural crest migration. PMID: 15857909
    10. This work provides evidence for distinct roles for XTcfs in regulating Wnt target gene expression. PMID: 16325796
    11. In Xenopus laevis there is clear requirement for VegT, Vg1 and Wnt11 in body pattern formation. PMID: 17219372
    12. Wnt5a and Wnt11 form a previously unrecognized complex PMID: 18927149
    13. Sfrp5 locally inhibits Wnt11 to maintain early foregut identity and to allow an epithelium to form over a mass of tissue undergoing Wnt-mediated cell movements. PMID: 18981481

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Wnt family
  • 组织特异性：
    Transcripts are expressed ubiquitously in early oocytes but become vegetally localized during mid-oogenesis then enriched on the dorsal side by the 8 to 16 cell stage. The protein becomes asymmetrically concentrated on the dorsal side by the 64-cell stage
  • 数据库链接：

    KEGG: xla:399441

    UniGene: Xl.24008