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  4. Recombinant Xenopus laevis Stromelysin-3 (mmp11)

Recombinant Xenopus laevis Stromelysin-3 (mmp11)

  • 货号：
    CSB-YP606100XBE
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP606100XBE
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP606100XBE-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP606100XBE
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP606100XBE
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    mmp11
  • Uniprot No.：
  • 别名：
    mmp11; Stromelysin-3; ST3; EC 3.4.24.-; Matrix metalloproteinase-11; MMP-11
  • 种属：
    Xenopus laevis (African clawed frog)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    86-477
  • 氨基酸序列
    FVLSG GRWDKTNLTY KIIRFPWQLS KVKVRRTIAE ALKVWSEVTP LTFTEVHEGR SDIIIDFTRY WHGDNLPFDG PGGILAHAFF PKTHREGDVH FDYDEAWTIG NNIGTDLLQV AAHEFGHMLG LQHSSISKSL MSPFYTFRYP LSLSADDKHG IQFLYGAPRP PTPSPTPRVE VNQVENESNE IPAAEPDACK TNFDAVSTIR GELFFFKSGY VWRLRGGKLQ NGYPALASRH WRGIPDTVDA AFEDSVGNIW FFYGSQFWVF DGKLQASGPF PITDIGISVT QIQAAFVWGT EKNKKTYLFR GGEYWRFNPE TRRVESRHSR RIGDWRGVPK GIDAAFQDEQ GYAYFVKGRQ YWKFDPFKVR VMDGYPHLIS QDFFNCQASS TFVNSLR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be involved in the modification of the extracellular matrix during metamorphic apoptosis.
  • 基因功能参考文献：
    1. Transgenic tadpoles were prepared with an elastase promoter driving either the ST3 gene or the constitutively active form of Notch (IC). PMID: 21194527
    2. analysis of substrate specificity for stromelysin-3: alpha1-PI is unlikely to be a physiological substrate PMID: 15254771
    3. ST3 regulates cell fate and tissue morphogenesis through direct or indirect extracellular matrix remodeling PMID: 15929979
    4. Laminin receptor precursor cleavage by ST3 plays a role in both physiological and pathological processes. PMID: 16059908
    5. thyroid hormone regulation of Xenopus laevis Stromelysin-3 is mediated by a DNA element in the first intron PMID: 16606608
    6. Mutational analysis of the cleavage of the cancer-associated laminin receptor by stromelysin-3 reveals the contribution of flanking sequences to site recognition and cleavage efficiency. PMID: 19212658
    7. ST3 expression, in the absence of T3 hormone, caused significant muscle cell death in the tail of premetamorphic transgenic tadpoles PMID: 19429683

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Peptidase M10A family
  • 组织特异性：
    Expressed in fibroblast cells that are activated by thyroid hormone. High levels in resorbing tail.
  • 数据库链接：

    KEGG: xla:379501

    UniGene: Xl.112