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  4. Recombinant Xenopus laevis Thyroid hormone receptor alpha-A (thra-a)

Recombinant Xenopus laevis Thyroid hormone receptor alpha-A (thra-a)

  • 货号：
    CSB-YP322758XBE
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP322758XBE
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP322758XBE-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP322758XBE
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP322758XBE
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    thra-a
  • Uniprot No.：
  • 别名：
    thra-a; nr1a1-a; thra1; Thyroid hormone receptor alpha-A; TRalphaA; XenTR-alpha1; Nuclear receptor subfamily 1 group A member 1-A
  • 种属：
    Xenopus laevis (African clawed frog)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-418
  • 氨基酸序列
    MDQNLSGLDC LSEPDEKRWP DGKRKRKNSQ CMGKSGMSGD SLVSLPSAGY IPSYLDKDEP CVVCSDKATG YHYRCITCEG CKGFFRRTIQ KNLHPSYSCK YDGCCIIDKI TRNQCQLCRF KKCIAVGMAM DLVLDDSKRV AKRKLIEENR QRRRKEEMIK TLQQRPEPSS EEWELIRIVT EAHRSTNAQG SHWKQRRKFL PEDIGQSPMA SMPDGDKVDL EAFSEFTKII TPAITRVVDF AKKLPMFSEL TCEDQIILLK GCCMEIMSLR AAVRYDPDSE TLTLSGEMAV KREQLKNGGL GVVSDAIFDL GRSLAAFNLD DTEVALLQAV LLMSSDRTGL ICTDKIEKCQ ETYLLAFEHY INHRKHNIPH FWPKLLMKVT DLRMIGACHA SRFLHMKVEC PTELFPPLFL EVFEDQEV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    High affinity receptor for triiodothyronine (T3).
  • 基因功能参考文献：
    1. Furthermore, molecular and transgenic studies have shown that unliganded TRalpha accomplishes these via the recruitment of histone deacetylase (HDAC)-containing corepressor complexes to repress the expression of TH-inducible genes PMID: 26219216
    2. regions of the Xenopus and mouse Klf9 genes 5-6 kb upstream of the transcription start sites that supported synergistic transactivation by TH plus GC. PMID: 25866873
    3. Type 2 iodothyronine deiodinase activity is required for the death of thyroid hormone receptor (TRalpha)-transfected tail muscle cells induced by a low level of thyroid hormone. PMID: 22686326
    4. Data provide in vivo evidence for targeted recruitment of N-CoR/SMRT-TBLR1 complexes by unliganded thyroid hormone receptors in transcriptional repression during vertebrate development. PMID: 15060155
    5. Data show that thyroid hormone receptors directly mediate the developmental effects of thyroid hormone in individual organs by regulating target gene expression in these organs. PMID: 15456876
    6. investigated the role of steroid receptor coactivator 3 (SRC3) in gene activation by thyroid hormone receptor (TR) in vivo during development PMID: 15901728
    7. one mechanism for tissue- and gene-specific regulation of TR target gene expression is through tissue and developmental stage-dependent regulation of TR levels PMID: 16236718
    8. Binding of liganded thyroid hormnone receptor to the target promoter is reduced when arginine methyltransferase 1 was overexpressed, accompanied by a slight reduction in histone methylation. PMID: 17312273
    9. PRMT1 functions transiently as a coactivator in thyroid hormone (T3) receptor (TR)-mediated transcription by enhancing TR-T3 response element binding and further suggest that PRMT1 has tissue-specific roles in regulating the rate of metamorphosis. PMID: 19047371
    10. T(3) acts to induce cell proliferation in the tadpole brain predominantly, if not exclusively, via TRalpha. PMID: 19056375

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Nuclear hormone receptor family, NR1 subfamily
  • 数据库链接：

    KEGG: xla:397942

    UniGene: Xl.309