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  4. Recombinant Xenopus laevis Transcription factor Sox-9-A (sox9-a)

Recombinant Xenopus laevis Transcription factor Sox-9-A (sox9-a)

  • 中文名称：
    有爪蟾蜍sox9-a重组蛋白
  • 货号：
    CSB-YP489611XBE
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    有爪蟾蜍sox9-a重组蛋白
  • 货号：
    CSB-EP489611XBE
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    有爪蟾蜍sox9-a重组蛋白
  • 货号：
    CSB-EP489611XBE-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    有爪蟾蜍sox9-a重组蛋白
  • 货号：
    CSB-BP489611XBE
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    有爪蟾蜍sox9-a重组蛋白
  • 货号：
    CSB-MP489611XBE
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    sox9-a
  • Uniprot No.：
  • 别名：
    sox9-a; sox9; Transcription factor Sox-9-A
  • 种属：
    Xenopus laevis (African clawed frog)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-477
  • 氨基酸序列
    MNLLDPFMKM TEEQDKCMSG APSPTMSDDS AGSPCPSGSG SDTENTRPQE NTFPKGDQEL KKETEDEKFP VCIREAVSQV LKGYDWTLVP MPVRVNGSSK NKPHVKRPMN AFMVWAQAAR RKLADQYPHL HNAELSKTLG KLWRLLNEGE KRPFVEEAER LRVQHKKDHP DYKYQPRRRK SVKNGQTEQE DGAEQTHISP NAIFKALQAD SPHSSSSMSE VHSPGEHSGQ SQGPPTPPTT PKTDIQPGKP DLKREGRPLQ ENGRQPPHID FRDVDIGELS SEVISTIETF DVNEFDQYLP PNGHPGVGST QASYTGSYGI SSTPSATTGA GPAWMSKQQQ QQPQQHSLST LNSEQSQSQQ RTHIKTEQLS PSHYSDQQQQ HSPQQLNYSS FNLQHYSSSY PTITRAQYDY TEHQGSSTYY SHASGQNSGL YSTFSYMNPS QRPLYTPIAD TTGVPSIPQT HSPQHWEQPV YTQLTRP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that plays a key role in chondrocytes differentiation and skeletal development. Specifically binds the 5'-ACAAAG-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including COL2A1. Plays a central role in successive steps of chondrocyte differentiation. Absolutely required for precartilaginous condensation, the first step in chondrogenesis during which skeletal progenitors differentiate into prechondrocytes. Together with SOX5 and SOX6, required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes, the second step in chondrogenesis. Later, required to direct hypertrophic maturation and block osteoblast differentiation of growth plate chondrocytes: maintains chondrocyte columnar proliferation, delays prehypertrophy and then prevents osteoblastic differentiation of chondrocytes. Also required for chondrocyte hypertrophy, both indirectly, by keeping the lineage fate of chondrocytes, and directly, by remaining present in upper hypertrophic cells. Low lipid levels are the main nutritional determinant for chondrogenic commitment of skeletal progenitor cells: when lipids levels are low, FOXO transcription factors promote expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation. In addition to cartilage development, also acts as a regulator of proliferation and differentiation in epithelial stem/progenitor cells. Involved in development of the cranial neural crest, which is fated to form skeletal elements. Also required for otic placode specification during inner ear development.
  • 基因功能参考文献：
    1. Downregulation of Mustn1 results in decrease expression of Sox9 and overall craniofacial cartilage formation. PMID: 22281807
    2. In addition to its early role in placode specification, Sox9 is also required for the maintenance of progenitors in the otic epithelium. PMID: 20201105
    3. One of the earliest genes expressed in the presumptive pancreatic tissue. PMID: 14584783
  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 组织特异性：
    From mid-gastrula (stage 10.5-11), expressed in a ring around the blastopore, with expression decreasing toward the dorsal side. At stage 12, expression around the blastopore decreases and begins to increase lateral to the neural plate in the presumptive
  • 数据库链接：

    KEGG: xla:399405

    UniGene: Xl.1690