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  4. Recombinant Chicken Cadherin-2 (CDH2)

Recombinant Chicken Cadherin-2 (CDH2)

  • 货号：
    CSB-CF005045CH
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    CDH2; Cadherin-2; Neural cadherin; N-cadherin
  • 种属：
    Gallus gallus (Chicken)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    165-912
  • 氨基酸序列
    DWVIPPINLPENSRGPFPQELVRIRSDRDKSLSLRYSVTGPGADQPPTGIFIINPISGQLSVTKPLDREQIASFHLRAHAVDVNGNQVENPIDIVINVIDMNDNRPEFLHQVWNGTVPEGSKPGTYVMTVTAIDADDPNAQNGMLRYRILSQAPSSPSPNMFTINNETGDIITVAAGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGEVPENRVDVIVANLTVTDKDQPHTPAWNARYQMTGGDPTGQFTILTDPNSNDGLVTVVKPIDFETNRMFVLTVAAENQVPLAKGIQHPPQSTATVSITVIDVNESPYFVPNPKLVRQEEGLLAGSMLTTFTARDPDRYMQQTSLRYSKLSDPANWLKIDPVNGQITTTAVLDRESIYVQNNMYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVNPKEATTCETLQPNAINITAVDPDIDPNAGPFAFELPDSPPSIKRNWTIVRISGDHAQLSLRIRFLEAGIYDVPIVITDSGNPHASSTSVLKVKVCQCDINGDCTDVDRIVGAGLGTGAIIAILLCIIILLILVLMFVVWMKRRDKERQAKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPDTVEPDAIKPVGIRRLDERPIHAEPQYPVRSAAPHPGDIGDFINEGLKAADNDPTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGEQDYDYLNDWGPRFKKLADMYGGGDD
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion. Cadherins may thus contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development.
  • 基因功能参考文献：
    1. in chicken and mouse embryos, PAPC expression is tightly regulated by the clock and wavefront system in the posterior PSM and exhibits a striking complementary pattern to N-cadherin PMID: 28087631
    2. N-cadherin stops the leftward cell movements and that this termination is an essential step in the establishment of left-right asymmetry PMID: 25117685
    3. Inhibition of ADAM10 can inhibit Pax6 expression and N-cadherin ectodomain shedding in retinal cells, possibly affecting neurite outgrowth and ganglion cell differentiation. PMID: 23129104
    4. These findings suggest that ligand-selective mechanotransduction may supersede differences in cadherin binding affinities in regulating intercellular contacts. PMID: 22718345
    5. overexpressing N-cadherin on axons prevents the formation of the lateral funiculus and the spinocerebellar tract PMID: 23115176
    6. Data found that deployment of the E- to N-cadherin switch program varies considerably along the embryonic axis. PMID: 22684994
    7. N-Cadherin is a retinoic acid-regulated developmental gene that has been identified as participating in building the heart during embryonic development. PMID: 22254040
    8. Regulation of cadherin expression by gonadotropins and the presence of N-cadherin in the ovarian cortex suggest that these adhesion molecules are involved in ovarian morphogenesis in the chicken embryo. PMID: 22019531
    9. PTP1B promotes the association of p120 to the N-cadherin precursor, facilitating the trafficking of the complex from the endoplasmic reticulum to the Golgi complex. PMID: 20181825
    10. Expression of N-cadherin at the synaptic level on the somata and the proximal neurites of identified neuron populations has been traced selectively in the developing chicken visual system. PMID: 15312902
    11. changes in the molecular composition of the N-cadherin complex (represented by the uncoupling of p120-catenin and association with presenilin 1) may correspond to distinct functional states of the complex involved in synaptic maturation PMID: 16046145
    12. Co-immunoprecipitation and co-clustering paradigms were used to show that both NCAM and N-cadherin can interact with the 3Ig IIIC isoform of the FGFR1 in a number of cell types. PMID: 17005551
    13. PIP5KIgamma-mediated generation of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) at sites of N-cadherin contacts regulates intercellular adhesion strength, an effect due in part to PI(4,5)P2-mediated regulation of gelsolin. PMID: 17538019
    14. Treatment of cultures with C-type natriuretic peptide significantly increased N-cadherin, and collagen type X expression, glycosaminoglycan synthesis and chondrogenesis PMID: 18461555
    15. novel vimentin-linked/N-cadherin gamma-catenin junction provides the tensile strength necessary to establish and maintain structural integrity in tissues that lack desmosomes, such as the crystalline lens. PMID: 18514185
    16. CDH2 is associated with CTNNB1 to promote neural crest cell migration (velocity of migration is calculated). PMID: 15254905

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell membrane, sarcolemma. Cell junction. Cell surface.
  • 组织特异性：
    Detected in embryonic brain and heart (at protein level). Detected in embryonic brain and heart.
  • 数据库链接：

    KEGG: gga:414745

    STRING: 9031.ENSGALP00000024371

    UniGene: Gga.1917