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  4. Recombinant Dog Cytochrome c oxidase subunit 2 (MT-CO2)

Recombinant Dog Cytochrome c oxidase subunit 2 (MT-CO2)

  • 中文名称：
    熟悉的犬MT-CO2重组蛋白
  • 货号：
    CSB-CF015073DO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    MT-CO2; COII; COX2; COXII; MTCO2; Cytochrome c oxidase subunit 2; Cytochrome c oxidase polypeptide II
  • 种属：
    Canis familiaris (Dog) (Canis lupus familiaris)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-227
  • 氨基酸序列
    MAYPFQLGLQDATSPIMEELLHFHDHTLMIVFLISSLVLYIISLMLTTKLTHTSTMDAQE VETVWTILPAIILILIALPSLRILYMMDEINNPSLTVKTMGHQWYWSYEYTDYEDLNFDS YMIPTQELKPGELRLLEVDNRVVLPMEMTIRMLISSEDVLHSWAVPSLGLKTDAIPGRLN QTTLMAMRPGLYYGQCSEICGSNHSFMPIVLEMVPLSYFETWSALMV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
  • 基因功能参考文献：
    1. high expression in mast cell tumours associated with proliferation, angiogenesis and decreased survival PMID: 28467670
    2. gene expression of COX-2 and prostaglandin E synthase may be involved in the regulation of patency in the uterine cervix of bitches with pyometra PMID: 26596635
    3. The present results suggest that the COX-2(+)/EGFR(+) status may be part of a strategy adopted by tumor cells to evade the cytotoxic tumor-specific immune responses PMID: 25964576
    4. COX-2 was expressed 141-fold more in canine osteosarcoma cancer stem cell spheres than daughter adherent cells. PMID: 24416158
    5. These results confirm that COX-2 is expressed in the neoplastic glandular epithelial cells in canine anal sac adenocarcinoma (ASAC) and suggest a potential role for COX-2 inhibitors in the management of ASAC. PMID: 23778258
    6. In the gliomas reported in this study, none expressed COX2; none were immunoreactive for c-kit, although all three high-grade tumours had intramural vascular expression. PMID: 22235799
    7. COX-2 is expressed at high level in osteosarcoma and support the use of COX-2 inhibitors to improve the response to chemotherapy. PMID: 22633646
    8. Renal COX-2 is induced in canine and feline CKD, especially in relation to the glomerular changes; no significant correlations were found for COX-1 PMID: 22244709
    9. mutations in the Cox-2 gene could be the cause of renal dysplasia in dogs PMID: 21346820
    10. This study evaulated neoplastic cyclooxygenase-2 expression in correlation with other neoplasm traits such as: histological type, the differentiation grade, proliferative activity, estrogenic receptor, as well as Hsp70 and p53 proteins expression. PMID: 20731190
    11. Investigation of prognostic value of COX2 in prognosis of dog malignant mammry tumors. PMID: 19939424
    12. Inhibition of COX-2 improves transplanted cardiac function following long-term preservation. PMID: 16713604
    13. These results demonstrate a new function for TonEBP/NFAT5, i.e., to mediate hypertonic-induced COX2 expression, and suggest that osmoprotection strongly depends on COX2 protein levels. PMID: 19146830
    14. COX-2 expression in canine normal and neoplastic mammary gland is reported. PMID: 19203768

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  • 亚细胞定位：
    Mitochondrion inner membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Cytochrome c oxidase subunit 2 family
  • 数据库链接：

    KEGG: cfa:804479

    STRING: 9615.ENSCAFP00000030312