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  4. Recombinant Dog cGMP-gated cation channel alpha-1 (CNGA1)

Recombinant Dog cGMP-gated cation channel alpha-1 (CNGA1)

  • 货号：
    CSB-CF638923DO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    CNGA1; CNCG; CNCG1; cGMP-gated cation channel alpha-1; Cyclic nucleotide-gated cation channel 1; Cyclic nucleotide-gated channel alpha-1; CNG channel alpha-1; CNG-1; CNG1; Cyclic nucleotide-gated channel, photoreceptor; Rod photoreceptor cGMP-gated channel subunit alpha
  • 种属：
    Canis familiaris (Dog) (Canis lupus familiaris)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-691
  • 氨基酸序列
    MKKNIINTWYSFVNIPNVIVPDIEKEIRRMENGARSSFSDDDGDDDSASMFEESENETPH ARDSCRNNSQRRDPSQREQYLPGAIALFNVNNSSNKEQEPKEKKKKKKEKKSKSGDKNEN KKDSEKKKKKEKEKEKKNKEEKGKDKKEEEKKEVMVIDPAGNMYYNWLFCITLPVMYNWT MVIARACFDELQSDYLEYWIIFDYLSDIVYLLDMFVRTRTGYLEQGLLVREEAKLIEKYK SNLQFKLDFLSVIPTDLLYFKLGWNYPEIRLNRLLRISRMFEFFQRTETRTNYPNIFRIS NLVMYIVIIIHWNACVYFSISKAIGFGNDTWVYPDVNDPEFGRLARKYVYSLYWSTLTLT TIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYM HFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFA DCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGITQFVVLSDG SYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQ ILMKDGLLDINIANAGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQQKLKQRLTK VERFLKPIIDTEFSALEGTGDESRPLDSTQD
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential.
  • 基因功能参考文献：
    1. a CNGA1 mutation causes progressive retinal atrophy in Shetland sheepdogs PMID: 26202106
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Cyclic nucleotide-gated cation channel (TC 1.A.1.5) family, CNGA1 subfamily
  • 数据库链接：

    KEGG: cfa:403891

    STRING: 9615.ENSCAFP00000035274

    UniGene: Cfa.3753