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  4. Recombinant Drosophila melanogaster Calcium release-activated calcium channel protein 1 (olf186-F)

Recombinant Drosophila melanogaster Calcium release-activated calcium channel protein 1 (olf186-F)

  • 中文名称：
    黑腹果蝇olf186-F重组蛋白
  • 货号：
    CSB-CF890637DLU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    olf186-F
  • Uniprot No.：
  • 别名：
    Orai; CRACM1; olf186-F; CG11430; Calcium release-activated calcium channel protein 1; Protein orai
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-351
  • 氨基酸序列
    MSVWTTANNSGLETPTKSPITSSVPRAARSSAVITTGNHQQHHFQHVVAAAVAAATSVAT GHQFQQQFPLHAHPHPQHHSNSPTGSGSNSNNSAGFQRTSISNSLLQFPPPPPPSSQNQA KPRGHHRTASSSMSQSGEDLHSPTYLSWRKLQLSRAKLKASSKTSALLSGFAMVAMVEVQ LDHDTNVPPGMLIAFAICTTLLVAVHMLALMISTCILPNIETVCNLHSISLVHESPHERL HWYIETAWAFSTLLGLILFLLEIAILCWVKFYDLSPPAAWSACVVLIPVMIIFMAFAIHF YRSLVSHKYEVTVSGIRELEMLKEQMEQDHLEHHNNIRNNGMNYGASGDIV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores. Regulates transcription factor NFAT nuclear import.
  • 基因功能参考文献：
    1. Ca2+ uptake in neurons with reduced SEPT7 requires Orai. PMID: 27225060
    2. These studies suggest that modulation of SOCE could serve as a novel mechanism for restoring dopamine levels in dopaminergic neurons. PMID: 26446229
    3. The crystal structure of Orai from Drosophila melanogaster, determined at 3.35 angstrom resolution, reveals that the calcium channel is composed of a hexameric assembly of Orai subunits arranged around a central ion pore. PMID: 23180775
    4. Orai1 is an essential component or regulator of the CRAC channel complex PMID: 16582901
    5. results demonstrate that the protein CRACM1 encoded by olf186-F is essential for store-operated Ca2+ influx via Ca2+ release-activated Ca2+ (CRAC) channels PMID: 16645049
    6. results indicate that Orai itself forms the Ca2+-selectivity filter of the CRAC channel PMID: 16921385
    7. The human ortholog of drosophila olf186-F interacts with STIM1 to regulate the amplitude of store-operated calcium entry. PMID: 16733527

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Orai family
  • 数据库链接：

    KEGG: dme:Dmel_CG11430

    STRING: 7227.FBpp0113106

    UniGene: Dm.7627