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  4. Recombinant Drosophila melanogaster G-protein coupled receptor Mth (mth)

Recombinant Drosophila melanogaster G-protein coupled receptor Mth (mth)

  • 中文名称：
    黑腹果蝇mth重组蛋白
  • 货号：
    CSB-CF529762DLU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    mth
  • Uniprot No.：
  • 别名：
    mth; CG6936; G-protein coupled receptor Mth; Protein methuselah
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    25-514
  • 氨基酸序列
    DILECDYFDTVDISAAQKLQNGSYLFEGLLVPAILTGEYDFRILPDDSKQKVARHIRGCV CKLKPCVRFCCPHDHIMDNGVCYDNMSDEELAELDPFLNVTLDDGSVSRRHFKNELIVQW DLPMPCDGMFYLDNREEQDKYTLFENGTFFRHFDRVTLRKREYCLQHLTFADGNATSIRI APHNCLIVPSITGQTVVMISSLICMVLTIAVYLFVKKLQNLHGKCFICYMVCLFMGYLFL LLDLWQISISFCKPAGFLGYFFVMAAFFWLSVISLHLWNTFRGSSHKANRFLFEHRFLAY NTYAWGMAVVLTGITVLADNIVENQDWNPRVGHEGHCWIYTQAWSAMLYFYGPMVFLIAF NITMFILTAKRILGVKKDIQNFAHRQERKQKLNSDKQTYTFFLRLFIIMGLSWSLEIGSY FSQSNQTWANVFLVADYLNWSQGIIIFILFVLKRSTWRLLQESIRGEGEEVNNSEEEISL ENTTTRNVLL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in biological aging and stress response. Essential for adult survival. Required in the presynaptic motor neuron to up-regulate neurotransmitter exocytosis at larval glutamatergic neuromuscular junctions (NMJs). Regulates a step associated with docking and clustering of vesicles at release sites. SP/Acp70A and sun are agonists that activate mth in vitro.
  • 基因功能参考文献：
    1. this study identifies Methuselah (Mth) as a secretin-incretin receptor subfamily member required in the insulin-producing cells for proper nutrient coupling. PMID: 27708106
    2. Methuselah gene mutation is associated with tolerance of dichlorvos exposure in Drosophila melanogaster. PMID: 25746179
    3. mth has a statistically significant advantage in maintaining continuous flight over control flies at age 10 days, but not during middle and late life. mth flies had lower levels of locomotor activity relative to controls at ages 50 and 60 days. PMID: 23913251
    4. While our data support a role for mth variation being under natural selection, we found no link to naturally occurring variation in lifespan and ageing in Australian populations of D. melanogaster. PMID: 23802551
    5. Identified two additional activators of Mth signaling: Drosophila Sex Peptide (SP) and a novel peptide (Serendipitous Peptide Activator of Mth, SPAM). PMID: 19672878
    6. where the life span is extended, there is an offsetting effect on reproductive output, suggesting that the methuselah mutation induces trade-off effects and is not a direct, mechanistic regulator of the aging process. PMID: 16677788
    7. Mth gene delays chronological aging but also enhances sensorimotor abilities critical to survival during early and middle, but not late life. PMID: 17534708
    8. allelic variation at mth contributes to observed differences in lifespan and correlated phenotypes in natural populations of Drosophila PMID: 18414670

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Note=Plasma membrane of presynaptic terminals and innervating axons.
  • 蛋白家族：
    G-protein coupled receptor 2 family, Mth subfamily
  • 数据库链接：

    KEGG: dme:Dmel_CG6936

    STRING: 7227.FBpp0072470

    UniGene: Dm.4379