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  4. Recombinant Epstein-Barr virus Protein BNLF2a (BNLF2a)

Recombinant Epstein-Barr virus Protein BNLF2a (BNLF2a)

  • 中文名称：
    Recombinant Epstein-Barr virus Protein BNLF2a (BNLF2a)
  • 货号：
    CSB-CF313737EFA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    BNLF2a
  • Uniprot No.：
  • 别名：
    BNLF2a; Protein BNLF2a
  • 种属：
    Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-60
  • 氨基酸序列
    MVHVLERALLEQQSSACGLPGSSTETRPSHPCPEDPDVSRLRLLLVVLCVLFGLLCLLLI
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Participates in viral evasion from HLA class I-restricted T-cell immunity. Associates with host TAP1 and TAP2 and prevents TAP-mediated peptide transport and subsequent loading.
  • 基因功能参考文献：
    1. BNLF2a provides immune evasion properties to infected cells through inhibition of transporter associated with antigen processing (TAP)-transport of antigen peptides. BNLF2a is expressed in nearly half of EBV-associated gastric carcinomas. analyzed. PMID: 26178981
    2. N-terminal amino acid residues influence immune-evasive properties of BNLF2a. PMID: 22013037
    3. To optimally accomplish immune evasion, BNLF2a is composed of two specialized domains: its C-terminal tail anchor ensures membrane integration and endoplasmic reticulum retention, whereas its cytosolic N- terminus accomplishes inhibition of TAP function. PMID: 21296983
    4. during productive EBV infection, BNLF2a contributes to TAP inhibition and surface HLA class I down-regulation PMID: 19201886
  • 亚细胞定位：
    Host endoplasmic reticulum membrane; Single-pass membrane protein.
  • 蛋白家族：
    Lymphocryptovirus BNLF2a family
  • 数据库链接：

    KEGG: vg:3783720