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  4. Recombinant Human Aquaporin-8 (AQP8)

Recombinant Human Aquaporin-8 (AQP8)

  • 货号：
    CSB-CF001972HU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    AQP8
  • Uniprot No.：
  • 别名：
    AQP8; Aquaporin-8; AQP-8
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-261
  • 氨基酸序列
    MSGEIAMCEPEFGNDKAREPSVGGRWRVSWYERFVQPCLVELLGSALFIFIGCLSVIENGTDTGLLQPALAHGLALGLVIATLGNISGGHFNPAVSLAAMLIGGLNLVMLLPYWVSQLLGGMLGAALAKAVSPEERFWNASGAAFVTVQEQGQVAGALVAEIILTTLLALAVCMGAINEKTKGPLAPFSIGFAVTVDILAGGPVSGGCMNPARAFGPAVVANHWNFHWIYWLGPLLAGLLVGLLIRCFIGDGKTRLILKAR
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Forms a water-specific channel; mercury-sensitive. Not permeable to glycerol or urea.
  • 基因功能参考文献：
    1. Structural basis for mutations in human AQP8 associated with colorectal cancer has been described. PMID: 29799470
    2. Aquaporin 8 expression is regulated by cholesterol in hepatic cells PMID: 28322010
    3. The control of AQP8-mediated H2O2 transport provides a novel mechanism to regulate cell signaling and survival during stress. PMID: 26972385
    4. In particular, AQP8 affected VEGF-induced redox signaling by increasing the sulfenation of the tumor suppressor PTEN, which resulted in its inactivation and, in turn, caused Akt activation. PMID: 27862460
    5. Aquaporins AQP3, -7, -8, and -11 proteins were found in sperm cells and localized in the head (AQP7), in the middle piece (AQP8) and in the tail (AQP3 and -11) in both the plasma membrane and in intracellular structures. PMID: 28042826
    6. No significant relationship was found between gallbladder mucosa aquaporin expression and the presence or absence of gallbladder stones. PMID: 26707370
    7. AQP6 and AQP8 had different expression degrees in epithelial ovarian tissues, which suggests that AQP6 and AQP8 may play certain roles in epithelial ovarian tumors. PMID: 26779650
    8. EGF induces AQP8 expression and cell migration in Eca-109 cells via the EGFR/Erk1/2 signal transduction pathway. PMID: 25550802
    9. increased AQP8, Erk1/2 and phosphorylated-Erk1/2 expression may play a role in transformation of cervical intraepithelila neoplasia into cervical cancer, and in early invasion and lymphatic metastasis of cervical cancer PMID: 25120769
    10. mtAQP8 knockdown induces necrotic cell death in human neoplastic hepatic cells, a finding that might be relevant to therapeutic strategies against hepatoma cells. PMID: 24415197
    11. AQP8 and its relationship with miRNAs may be involved in the pathogenesis of Ulcerative colitis (UC). PMID: 23595390
    12. AQP8 has a role in the pathogenesis of PCOS. PMID: 23953589
    13. the results here reported indicate that AQP8 is able to modulate H2O2 transport through the plasma membrane affecting redox signalling linked to leukaemia cell proliferation PMID: 24440277
    14. High Aquaporin 8 expression is associated with invasion of cervical cancer. PMID: 23679281
    15. The expression levels and immunoreactive score of AQP8 protein and mRNA increased in low-grade astrocytomas, and further increased in high-grade astrocytomas, especially in glioblastoma. PMID: 24055034
    16. AQP8 expression significantly increased in advanced stage of cervical cancer, deeper infiltration, metastatic lymph nodes and larger tumor volume. PMID: 22901156
    17. Reconstitution of water channel function and 2D-crystallization of human aquaporin 8. PMID: 22192778
    18. With the increase of cAMP, AQP8 mRNA and protein expressions significantly increased in WISH cells in vitro. PMID: 19087520
    19. The expression of AQP8 protein is positively correlated with bcl-2 protein in human cervical carcinoma. PMID: 18788571
    20. The expression of AQP8 mRNA and protein is significantly increased in the amnion and placenta of polyhydramnios, suggesting that AQP8 may play an important role in the regulation of amniotic fluid volume. PMID: 19563057
    21. When polyhydramnios occurs, expression of aquaporin 8 and aquaporin 9 in fetal membranes and placenta is an adaptive change. PMID: 20732771
    22. Data show that AQP-1, 3, 8, 9 mRNA expression was detected in both amnion and chorion and can be associated with intramembranous transport and volume regulation of amniotic fluid. PMID: 17545093
    23. Aquaporin 8 has a role in intramembranous water transport and the balance of amniotic fluid. PMID: 20144166
    24. Aquaporin 8 is expressed in colonic epithelial cells but was not detected in colorectal tumors. PMID: 11231887
    25. expression of aquaporin 8 water channel in and up-regulation by second messenger cyclic adenosine monophosphate. Aquaporin 8 messenger RNA has relatively short biologic half-life in vitro. PMID: 12712100
    26. Upregulation of AQP8 in the colon of ulcerative colitis patients represents a secondary phenomenon which may disturb the physiologic colonic mucus barrier and thus lead to chronic inflammation and ulceration. PMID: 17461471
    27. Knockdown of hepatocyte aquaporin-8 by RNA interference induces defective bile canalicular water transport. PMID: 18948439
    28. The crystal structure of deoxyhemoglobin S, 2HBS, demonstrates the interaction of the mutant valine with another hemoglobin tetramer and provides insights into formation of the intracellular sickle cell fiber. PMID: 9325099

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  • 亚细胞定位：
    Mitochondrion membrane; Multi-pass membrane protein.
  • 蛋白家族：
    MIP/aquaporin (TC 1.A.8) family
  • 组织特异性：
    Detected in the sperm midpiece (at protein level). Expressed only in pancreas and colon.
  • 数据库链接：

    HGNC: 642

    OMIM: 603750

    KEGG: hsa:343

    STRING: 9606.ENSP00000219660

    UniGene: Hs.176658