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  4. Recombinant Human C-C chemokine receptor type 3 (CCR3)

Recombinant Human C-C chemokine receptor type 3 (CCR3)

  • 货号：
    CSB-CF004842HU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    CCR3; CMKBR3; C-C chemokine receptor type 3; C C CKR3; C-C CKR-3; CC-CKR-3; CCR-3; CCR3; CKR 3; CKR3; Eosinophil eotaxin receptor; CD antigen CD193
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-355
  • 氨基酸序列
    MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILI KYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSE IFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEE TLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRL IFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVI YAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing the intracellular calcium ions level. In addition acts as a possible functional receptor for NARS1.; (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection.
  • 基因功能参考文献：
    1. MACs from Familial hypercholesterolemia (FH)-MACs have an inflammatory phenotype that is characterized by the up-regulation of CCR3, CCR4, and CXCR1 under the control of miR-505-3p. These results suggest a chronic inflammatory condition in FH innate immunity cells that is not reverted by standard lipid-lowering treatment PMID: 29457550
    2. CCR3 exists as a mixture of monomers and dimers under nearly physiological conditions. The monomeric CCR3 receptor is the minimal functional unit in cellular signal transduction. Agonists increase dimers and oligomers at high concentrations. Antagonists do not affect oligomeric status. Monomeric CCR3 exhibits a stronger chemotactic response in the migration assay of stably transfected CCR3 cells. PMID: 28994588
    3. Study shows that CCR3, receptor of CCL28, was highly expressed in vascular endothelial cells in lung adenocarcinoma and is targeted by CCL28 to regulate angiogenesis. PMID: 27250766
    4. Findings suggest that CCL11-CCR3 binding is involved in the progression of GBM. PMID: 27119233
    5. Data show that high mRNA expression of CCR3 was related with improved relapse-free survival in luminal-A/B. PMID: 27086913
    6. the expression of CCR3 on dispersed synovial tissue and peripheral blood cells in rheumatoid arthritis, was investigated. PMID: 27495116
    7. Chemokine receptors CCR3 and CCR4, and the mucosa specific chemokine CCL28 have predominant roles in oral wound healing by increasing human gingiva fibroblast proliferation, migration, and the secretion of IL-6 and HGF and reducing the secretion of TIMP-1. PMID: 28387445
    8. simvastatin was demonstrated to inhibit IL-5-induced CCR3 expression and chemotaxis of eosinophils mediated via the mevalonate pathway. PMID: 27275740
    9. Data indicate that approximately 4.5% dispersed osteoarthritis (OA) synovial tissue cells are CC chemokine receptor CCR 3 (CCR3)+ cells. PMID: 26409848
    10. This meta-analysis provides robust estimates that interleukin 18 receptor accessory protein rs917997 and chemokine (C-C motif) receptor 3 rs6441961 are potential risk factors for celiac disease in European populations. PMID: 26289103
    11. Periprostatic adipocytes drive prostate cancer progression in obesity via CCL7 secretion which stimulates CCR3 expressing tumor cells. PMID: 26756352
    12. Results show the structure of CCL11 bound to the sulfated N-terminal region of its receptor CCR3 and show that intact CCR3 is sulfated and sulfation enhances receptor activity. PMID: 25450766
    13. CCL28-CCR3 interactions are involved in the homeostatic trafficking of CD4(+) T cells to the upper airways. PMID: 24917456
    14. In vitro chemotaxis assay indicates dominant role of RANTES and IP-10 in the selective recruitment of CXCR3(+)CCR5(+)cells at the tubercular pathologic sites. PMID: 23643185
    15. CCR3-driven communication pathways from the epidermis to the dermis may modulate tissue remodeling in atopic skin inflammation. PMID: 23702389
    16. Retinoic acids up-regulate functional eosinophil-driving receptor CCR3. PMID: 23742077
    17. CCR3 demonstrates adequate sensitivity (83%) but weak specificity (59%) in its ability to reliably identify histamine-releasing activated basophils. PMID: 23955446
    18. Chemokine CCR3 ligands-binding peptides derived from a random phage-epitope library. PMID: 23183094
    19. Different GATA factors dictate CCR3 transcription in allergic inflammatory cells in a cell type-specific manner. PMID: 23636060
    20. rs3091250 single nucleotide polymorphism for CCR3 was found to be associated with age-related macular degeneration. PMID: 23566847
    21. CCR3 is strongly expressed by ASM cells in vitro and in vivo. Protection against cell death by CCR3 activation is dependent on p42/44 MAPK but does not affect caspase 3 mediated apoptosis. PMID: 22702503
    22. Methylation of CpG sites at the GATA elements in the regulatory regions fine-tunes CCR3 transcription. PMID: 22217447
    23. Cross-talk between CCR3 and VEGF signaling exists and may be important in choroidal neovascularization in human age-related macular degeneration. PMID: 21917937
    24. These results suggest that pulmonary epithelial CCR3 be involved in progression of lipopolysaccharide-induced lung inflammation by mediating release of IL-8. PMID: 21660963
    25. Data show that expression levels of CCL11 and CCR3 mRNA in the lesional skin of ALCL were significantly higher than those in normal skin. PMID: 21406396
    26. Leucocyte of children with infectious mononucleosis expressed higher level of CCR3 and lower level of CCR5. PMID: 21280323
    27. GATA-1 controls CCR3 transcription by interacting dynamically with multiple GATA sites in the regulatory region of the CCR3 gene. PMID: 21041734
    28. CCR3 expression in T-cells and the colon is increased in ulcerative colitis compared to inflammatory bowel disease and controls. PMID: 21077277
    29. CCR3 is differentially expressed on inflammatory cells in rheumatoid arthritis, while eotaxin-2, a potent CCR3 agonist, is differentially expressed in active disease. PMID: 20659406
    30. CCR3 genetic polymorphisms may contribute to the development of the aspirin exacerbated respiratory disease phenotype and may be used as a genetic marker for differentiating between the two major aspirin hypersensitivity phenotypes. PMID: 20022477
    31. interaction of eotaxins and CCR3 regulates the Th2-dominant tumor environment, which is closely related to the development of cutaneous T-cell lymphoma PMID: 20505746
    32. The T17C chemokine receptor 3 polymorphism appears to be associated with asthma BHR and disease severity but not with atopy. PMID: 20726325
    33. The present data are of interest with regard to the potential use of AZD3778 in allergic rhinitis and to the relative importance of eosinophil actions to the symptomatology of allergic rhinitis. PMID: 20144207
    34. data support the role of DCs in differential regulation of CCR3 and CCR4 on CD4+ T cells from HDM-sensitive and non-atopic asthmatics after Der p 1 exposure. PMID: 20364559
    35. Data show that both plasma eotaxin level and expression of CCR3 on CD4+ T cells were higher in allergic patients than controls in different types of allergy. PMID: 20306659
    36. Alanine scanning mutagenesis of CCR3 reveals that the three intracellular loops are essential for functional receptor expression. PMID: 11920572
    37. bronchial expression up-regulated in exacerbations of chronic bronchitis PMID: 11991282
    38. demonstrated that CCR3 is absent from the testes PMID: 11994538
    39. downstream promoter element dependent, general transcription control mechanism is conserved between Drosophila and human genes PMID: 12079287
    40. CCR3 is expressed by dendritic cells (DCs) differentiated from blood monocytes, DCs that emigrate from skin (epidermal and dermal DCs), and DCs derived from CD34+ hemopoietic precursors in bone marrow, umbilical cord blood, and leukapheresis collection. PMID: 12218106
    41. results suggest that expression of chemokine receptor 3(CCR3) and its ligand eotaxin/CCL11 plays a role in the recruitment and retention of CD30(+) malignant T cells to the skin PMID: 12393570
    42. This protein mobilizes to the surface of human mast cells and potentiates immunoglobulin E-dependent generation of interleukin 13. PMID: 12654630
    43. Eosinophil CCR3 expression between atopic individuals does not correlate with atopy or serum IgE levels, nor is the status of macrophage-inflammatory protein-1alpha-highly responsive donors associated with increased chemattractant receptor expression. PMID: 12794150
    44. eosinophil responses mediated by chemokines acting at CCR3 may be regulated by two distinct mechanisms: the antagonistic effects of CXCR3 ligands and the sequestration of CCL11 by CXCR3-expressing cells PMID: 12884299
    45. Ligation of CCR3 by eotaxin/chemokine ligand (CCL) 11 induces apoptosis in IL-2- and IL-4-stimulated primary CD19+ B cell cultures (approximately 40% apoptotic cells) as well as B cell lines, but has no effect on chemotaxis or cell adhesion. PMID: 12902471
    46. Single nucleotide polymorphism is not associated with atopic dermatitis in Japanese. PMID: 14581140
    47. the two N-terminal motifs of eotaxin must cooperate with other regions to successfully bind and activate CCR3 PMID: 14733956
    48. examination of the role of epidermal growth factor receptor in CCR3 signaling PMID: 15219825
    49. multiple residues on multiple extracellular domains of hCCR3 are important for coreceptor activity for HIV-1. PMID: 15476879
    50. the restoration of CRTH2(chemoattractant receptor-homologous molecule expressed on Th2 cells)/CCR3 expression may be an indicator for optimal recovery after septic shock PMID: 15507393

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    In eosinophils as well as trace amounts in neutrophils and monocytes.
  • 数据库链接：

    HGNC: 1604

    OMIM: 601268

    KEGG: hsa:1232

    STRING: 9606.ENSP00000441600

    UniGene: Hs.506190