Recombinant Human Cadherin-2 (CDH2)

1. Human keratinocyte cells reduce the N-cadherin levels of co-cultured melanoma cells. Cell-to-cell contact is necessary for this keratinocyte-mediated N-cadherin reduction. Keratinocytes reduce intracellular calcium in co-cultured melanoma cells. PMID: 29902459
2. The FGFR4-388arg variant promotes lung cancer progression by N-cadherin induction. PMID: 29402970
3. This study showed that the significant N-cadherin expression especially in high-grade meningioma group. PMID: 29297710
4. Our experiments presented a new mechanism adopted by GDNF supporting glioma development and indicated a possible therapeutic potential via the inhibition of proN-cadherin/FGFR1 interaction. PMID: 29750313
5. In patients with gastric cancer, the strong expression of N-cadherin in lymph nodes correlated with more lymph nodes metastasis, an advanced stage, and poor prognosis PMID: 28247164
6. Regulatory networks specifying cortical interneurons from human embryonic stem cells reveal roles for CHD2 in interneuron development PMID: 29229852
7. A study with nonsyndromic cleft lip with or without cleft palate (NSCL+/-P) cases (N=292) and controls (N=287) established association of a SNP in intron 2 of CDH2 with NSCL+/-P as a risk factor. PMID: 29524576
8. Results show that N-cadherin is highly expressed in 70% of patients with glioma. However, N-cadherin, as a representative EMT marker, have limited prognostic value in glioma. Nonetheless, the EMT process in gliomas may be compounded by enhanced N-cadherin expression supported by unfavorable prognostic outcomes. PMID: 28851312
9. Findings reveal the importance of CDH2-mediated cell contacts in preserving features of the juvenile nucleus pulposus cell phenotype. PMID: 27292569
10. Tumor-promoting role of N-cadherin in thyroid cancer was closely related to the activities of the MAPK/Erk, the phosphatidylinositol-3-kinase (PI3K)/Akt and p16/Rb signaling pathways. PMID: 28042956
11. Triple negative breast cancer cells surviving short-term chemotherapy treatment are more invasive than bulk tumor cells. Cell surface pro-N-cadherin expression is associated with the invasive and chemo-resistant behaviors of this tumor cell subset. PMID: 27768598
12. Sec8 regulates N-cadherin expression by controlling Smad3 and Smad4 expression through CBP, thereby mediating the epithelial-mesenchymal transition. PMID: 27769780
13. Results found that the N-glycan at N402 is comprised of beta 1,6 GlcNAc branching and that in glioma, deficient N402 N-glycosylation destabilises N-cadherin and leads to its proteasomal degradation. Destabilisation of N-cadherin inhibits cadherin-mediated cell-cell adhesion and promotes cell migration. Our findings imply that the control of N-cadherin stability by N-glycosylation is important in glioma migration. PMID: 27864899
14. In adrenocortical carcinomas, the loss of N-cadherin is a frequent phenomenon while the existence of TERT promoter mutations is not, and nuclear telomerase expression is present in only a minority of cases. PMID: 27886397
15. High CDH2 expression is associated with M2-type acute myeloid leukemia. PMID: 27064800
16. Migration of bone marrow-mesenchymal stem cells in response to TGF-beta was mediated through N-cadherin and noncanonical TGF-beta signals. PMID: 28213973
17. Studied the roles of MIRN145 in lung adenocarcinoma (LAC) and its targeting of N-cadherin. Knockdown of N-cadherin inhibited invasion and migration of LAC cell lines similar to overexpression of MIRN45. PMID: 28120164
18. Genetic mutations in CDH2-encoded N-cadherin may represent a novel pathogenetic basis for arrhythmogenic cardiomyopathy. PMID: 28326674
19. Extracellular and intracellular cleavage of N-cadherin might be involved in elevated MMP-9 expression enhancing tumor cell invasion. PMID: 27737648
20. a mechanism where the membrane organization of CD82, through specific posttranslational modifications, regulates N-cadherin clustering and membrane density, which impacts the in vivo trafficking of AML cells. PMID: 26592446
21. fluorescent imaging to demonstrate Ncad-mediated single cell responses to developmental cues within hydrogels towards chondrogenesis. PMID: 27106637
22. Our data demonstrate that N-Cadherin was markedly overexpressed and miR-199b-5p was significantly downregulated in hepatocellular carcinoma (HCC). MiR-199b-5p exerts inhibitory effects on EMT, and directly targets N-cadherin in HCC, supporting the potential utility of miR-199b-5p as a promising strategy to treat HCC PMID: 28588321
23. Study demonstrates a critical role of presynaptic cadherin/catenin/p140Cap cell adhesion complexes in stabilizing functional synapses and spines in the developing neocortex. PMID: 28641114
24. investigated the in vitro tumor/metastasis suppressor effects of plakoglobin in ovarian cancer cell lines with mutant p53 expression and different cadherin profiles PMID: 27144941
25. These results uncover a new role for p120 catenin bound to the N-cadherin precursor ensuring its trafficking through the biosynthetic pathway towards the cell surface. PMID: 27254316
26. Finding that the cells expressing N-cadherin gave rise to tumors with no expression of N-cadherin is in agreement with the classical view of epithelial to mesenchymal transition. Epithelial to mesenchymal transition and N-cadherin are associated with dissemination and not with the ability to establish new tumor growth. PMID: 27224422
27. These data implicate CDH2 mutations as novel genetic causes of Arrhythmogenic Right Ventricular Cardiomyopathy and contribute to a more complete identification of disease genes involved in cardiomyopathy. PMID: 28280076
28. High expression of N-cadherin is associated with bladder cancer. PMID: 27683053
29. Snail and N-cadherin are constitutively and inducibly expressed in papillary thyroid carcinoma PMID: 26219900
30. SFMSCs increased through upregulation of the activated lymphocyte cell adhesion molecule (ALCAM) and N-cadherin by microRNA-192 and -218 downregulation, similar to BMMSCs and ADMSCs. PMID: 28039611
31. the synergy between N-cadherin and FGFR signalling that ensure cellular reorganization during cell movements, mainly during cancer cell migration and metastasis but also during developmental processes. PMID: 27320194
32. Underexpression of CDH2 is associated with adrenocortical tumors. PMID: 27468715
33. Of the seven polymorphisms, two reached statistical significance for obsessive-compulsive disorder under additive and codominant models of inheritance PMID: 26093892
34. Targeting N-cadherin may be a promising therapeutic approach, particularly in cisplatin-resistant, therapy refractory and metastatic Germ cell tumor. PMID: 26451610
35. Metformin's anti-cancer therapeutic effect is mediated through different molecular mechanism in wild-type vs. deficient N-cadherin cancer cells. PMID: 26359363
36. Expression data of NCAD shows no association with advanced gastric cancer brain metastasis. PMID: 26260219
37. CDH2 was found to be a susceptibility gene for Gilles de la Tourette syndrome in a Danish cohort. PMID: 26032459
38. Existing knowledge regarding the role of CDH2 and CDH11 during development and differentiation in vivo and in vitro is reviewed. [review] PMID: 25771201
39. N-cadherin was widely expressed in CRC cell lines and silencing of N-cadherin suppressed the proliferation and migration of the CRC cell line HT-29 by upregulating E-cadherin, suggesting a potential role of N-cadherin in inducing EMT. PMID: 25936636
40. N-cadherin and connexin 43 expression in in group of diffuse astrocytomas and anaplastic astrocytomas may be evidence for their role in tumor formation and progression PMID: 25386667
41. Foxn3 is a direct transcriptional suppressor of N-cadherin in colorectal metastasis tissues. PMID: 26069251
42. the expression of N-cadherin was associated with Vasculogenic mimicry formation in esophageal squamous cell carcinoma PMID: 25575439
43. Results suggest that N-cadherin may promote motility and invasiveness through distinct mechanisms and that beta-catenin may be an integral mediator of N-cadherin-dependent invasive signaling in oral epithelia. PMID: 25175499
44. Results demonstrate that miR-194 affected the growth and metastasis of osteosarcoma cells both in vitro and in vivo suggesting that miR-194 functions as tumor suppressor gene probably by downregulating CDH2 and IGF1R. PMID: 25096247
45. association of beta-catenin with N-cadherin is regulated by actin polymerization during contractile activation PMID: 25713069
46. Decreased N-cadherin expression is linked to increased ADAM-10 expression in atherosclerotic lesions. PMID: 24985126
47. This indicates that similar biofunctionalization approaches based on N-cadherin and L1 can be translated to 3-D "transplantable" scaffolds with enhanced neurotrophic behaviors. PMID: 24914828
48. miR-199a targeted the sequence within the 3'UTR of the N-cadherin mRNA and suppressed the TGF-beta1-induced increase in the protein level of N-cadherin in a manner independent of SNAI1. PMID: 25041364
49. N-cadherin and CD133 expressions are strongly correlated and N-cadherin appears as a potential breast cancer metastases marker in a specific patient subpopulation. PMID: 24962344
50. High N-cadherin expression is associated with malignant bone and soft tissue tumors. PMID: 23799912

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HGNC: 1759

OMIM: 114020

KEGG: hsa:1000

STRING: 9606.ENSP00000269141

UniGene: Hs.464829