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  4. Recombinant Human Galactoside 2-alpha-L-fucosyltransferase 1 (FUT1)

Recombinant Human Galactoside 2-alpha-L-fucosyltransferase 1 (FUT1)

  • 中文名称：
    人FUT1重组蛋白
  • 货号：
    CSB-CF009073HU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    FUT1
  • Uniprot No.：
  • 别名：
    FUT1; H; HSC; Galactoside alpha-(1,2-fucosyltransferase 1; Alpha(1,2FT 1; Blood group H alpha 2-fucosyltransferase; Fucosyltransferase 1; GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1; Type 1 galactoside alpha-(1,2-fucosyltransferase FUT1; Type 2 galactoside alpha-(1,2-fucosyltransferase FUT1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-365
  • 氨基酸序列
    MWLRSHRQLCLAFLLVCVLSVIFFLHIHQDSFPHGLGLSILCPDRRLVTPPVAIFCLPGTAMGPNASSSCPQHPASLSGTWTVYPNGRFGNQMGQYATLLALAQLNGRRAFILPAMHAALAPVFRITLPVLAPEVDSRTPWRELQLHDWMSEEYADLRDPFLKLSGFPCSWTFFHHLREQIRREFTLHDHLREEAQSVLGQLRLGRTGDRPRTFVGVHVRRGDYLQVMPQRWKGVVGDSAYLRQAMDWFRARHEAPVFVVTSNGMEWCKENIDTSQGDVTFAGDGQEATPWKDFALLTQCNHTIMTIGTFGFWAAYLAGGDTVYLANFTLPDSEFLKIFKPEAAFLPEWVGINADLSPLWTLAKP
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose residue of glycoconjugates through an alpha(1,2) linkage leading to H antigen synthesis that is an intermediate substrate in the synthesis of ABO blood group antigens. H antigen is essential for maturation of the glomerular layer of the main olfactory bulb, in cell migration and early cell-cell contacts during tumor associated angiogenesis. Preferentially fucosylates soluble lactose and to a lesser extent fucosylates glycolipids gangliosides GA1 and GM1a.
  • 基因功能参考文献：
    1. The expression of FUT1, an alpha-1,2 fucosyltransferase, is remarkably down-regulated during melanoma progression, and the ectopic expression of FUT1 is sufficient to inhibit invadopodium formation and ECM degradation. PMID: 29924834
    2. FUT1 mutations responsible for the H-deficient phenotype in the Polish population, including the first example of an abolished start codon. PMID: 27893357
    3. The overexpression of miR-140-5p/149 inhibited apoptosis and promoted proliferation and autophagy of human primary chondrocytes via downregulating FUT1. PMID: 29488053
    4. Results show that c-Fos binding to TPA response element of FUT1 promoter enhances the activation of FUT1 transcription by c-Jun. PMID: 29130097
    5. miR-339-5p downregulation contributes to Taxol resistance in small-cell lung cancer by targeting FUT1. PMID: 28940895
    6. High FUT1 expression is associated with breast cancer. PMID: 26908442
    7. downregulation of FUT1, which leads to the perinuclear localization of LAMP-1 and 2, is correlated with increased rate of autophagic flux by decreasing mTOR signaling and increasing autolysosome formation. PMID: 27560716
    8. The H blood group system is defined by a terminal fucose residue found on red blood cells and in secretions formed by the action of alpha-1,2-fucosyltransferases 1 (alpha2FucT1) and 2 (alpha2FucT2), respectively. Mutant alleles of the corresponding FUT1 and FUT2 genes result in either a H- phenotype (Bombay phenotype) or a weak H phenotype (para-Bombay). Review. PMID: 27834485
    9. Two novel FUT1 mutations have been identified in the proband's FUT1 gene. The insertion mutation in the FUT1 that caused a shift of the open reading frame and formed a termination codon early at Amino Acid Position 334 may be the main reason for H deficiency in this case. PMID: 28026021
    10. Protein O-fucosyltransferase 1 promotes trophoblast cell proliferation by activating MAPK and PI3K/Akt signaling pathways.[poFUT1] PMID: 28103512
    11. Data suggest that the identification of genes in response to alpha1,2-fucosyl transferase (FUT1) may provide a theoretical basis for the investigations of the molecular mechanism of ovarian cancer. PMID: 27240592
    12. alpha(1,2)-fucosyltransferase activity is involved in the development of multidrug resistance of chronic myeloid leukemia cells probably through FUT1 regulated the activity of EGFR/MAPK signaling pathway and the expression of P-gp. PMID: 26986216
    13. data confirm the hypothesis that the h2 allele is linked to Se(357, 716), and the concurrence of unique FUT1 and FUT2 mutations is geographically specific. PMID: 25761312
    14. We show that fut1 in RA synovial fibroblasts is important in angiogenesis, leukocyte-synovial fibroblast adhesion, and synovial fibroblast proliferation PMID: 24467809
    15. Fut1 plays an important role in regulating angiogenesis and ICAM-1 expression in inflammatory arthritis. PMID: 24665114
    16. FUT1 mediates c-Jun-induced cell proliferation in ovarian cancer cells.c-Jun transcriptionally modulates FUT1 expression in ovarian cancer cells. PMID: 25239830
    17. Data indicate that single nucleotide polymorphism (SNPS) in the 3'-untranslated region of the fucosyltransferase 1 (FUT1) gene and intron of the syntaxin 1B (STX1B) gene were the top hits for Kawasaki disease (KD) susceptibility. PMID: 25101798
    18. Data indicate that alpha -1,2 fucosyltransferase (FUT1) 682A> G and 547_552delAG mutations do not affect the transcript efficiency, although various mutations have different impact on the enzyme's activity. PMID: 25297588
    19. Three new alleles in FUT1 and FUT2 genes were identified in the study. The allelic polymorphisms of FUT1 and FUT2 in Tibetans show a population-specific manner. PMID: 24527852
    20. FUT1-specific fucosidase diminishes the activation of beta1 integrin. PMID: 24593306
    21. FUT1 mRNA expression in DLD-1 cells is transcriptionally regulated by Elk-1. PMID: 23533340
    22. anti-H could accommodate grafts through triggering apoptosis and down-regulating Fut1 expression to reduce ABH antigens PMID: 23063462
    23. Macrophage-derived factors including LIF might facilitate development of an implantation-receptive endometrium by regulating surface glycan structures in epithelial cells by up-regulating FUT1 and FUT2. PMID: 22053055
    24. FUT1 allele 547-548delAG deletion and 658C>T missense mutation in part form the molecular basis of para-Bombay blood types. PMID: 22161108
    25. In summary, two novel non-functional FUT1 alleles (FUT1 649T and FUT1 35T, 423A) were identifi ed in para-Bombay individuals PMID: 21839020
    26. mutations of FUT1 gene did not affect the RNA and protein expression levels, but the enzyme activity of cells with FUT1 mutations was significantly decreased which resulted in the reduced expressin of H antigen. PMID: 21983725
    27. Data show that si-RNA induced down-regulation of FUT1 and FUT2 reduced expression of fucosylated nucleolin glycoforms and their exposure at the cell surface. PMID: 20506485
    28. The transfection of alpha1, 2-FT gene can increase the activity of alpha1, 2-FT in the cell line RMG-I and mainly increase the expression of Lewis y antigen simultaneously. PMID: 18686606
    29. FUT1 catalyses the addition of alpha-1,2-fucose to MUC1 and MUC5AC apomucins PMID: 12652076
    30. identification of an essential component of notch signaling pathways PMID: 12697902
    31. Four kinds of known h alleles (h1-h4), 2 kinds of novel non-functional FUT1 alleles, a Se(w) allele, and a novel SeG716A polymorphism in Chinese para-Bombay individuals were detected. PMID: 15476160
    32. A novel nonfunctional FUT1 allele C293T was identified in a person with the para-Bombay phenotype. PMID: 15847661
    33. Data show that the C35T substitution of FUT1 gene is not a mutation which gives rise to a non-functional h allele responsible for para-Bombay phenotype but a single nucleotide polymorphism in Chinese population. PMID: 16331565
    34. Expression of FUT1 induces changes in metastatic capacity of HT-29/M3 colon cancer cells, as a consequence of the altered expression pattern of type 2 Lewis antigens. PMID: 17459061
    35. Molecular genetic analysis of FUT1 and FUT2 gene was performed for seven Chinese Han individuals serologically typed as para-Bombay. PMID: 17922418
    36. Suppressing the expression of FUT1/4 by RNAi technology reduces the synthesis of LeY and inhibits cancer growth. PMID: 18023290
    37. Aberrant expression of a single glycosyltransferase can profoundly affect thymopoiesis, although the relative involvement of CD45-dependent and -independent mechanisms is yet to be determined. PMID: 18155296
    38. These observations point to a tumor induced transcription of endothelial FUT1 and consequently an enhanced expression of CD174 which is involved in migration and early cell-cell contacts during tumor associated angiogenesis. PMID: 18205178
    39. Expression of this human enzyme on porcine chondrocytes protects them from both humoral and cellular rejection. PMID: 18374127
    40. The findings indicate that alpha1,2-FT have the ability to enhance the proliferation and elevate the survival rates of RMG-I cells, which can promote the genesis and development of ovarian carcinoma. PMID: 19137814
    41. Multiple common and sporadic sequence variations including 14 new alleles at FUT1, FUT2, and FUT3 loci were identified. PMID: 19572973

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  • 亚细胞定位：
    Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Glycosyltransferase 11 family
  • 数据库链接：

    HGNC: 4012

    OMIM: 211100

    KEGG: hsa:2523

    STRING: 9606.ENSP00000312021

    UniGene: Hs.69747