Recombinant Human Interleukin-2 receptor subunit beta (IL2RB)

1. Characterization of interleukin receptor beta/gamma-associated protein complex assembly in IL-2- and IL-15-activated T-cells has been reported. PMID: 27463037
2. An association with the risk of erosion was observed for a haplotype of 2 single nucleotide polymorphisms of the IL-2RB gene in ACPA positive Rheumatoid arthritis patients. PMID: 26203933
3. CD112 downregulation resulted in a reduced ability of DNAM-1 to bind to the surface of both virus-infected and gD-transfected cells. PMID: 25352670
4. IL-2 receptor beta chain expression is drastically diminished on T cells in ANCA-associated vasculitis. PMID: 24648606
5. in anti-citrullinated protein antibody positive rheumatoid arthritis, the haplotype AC of IL-2RB was associated with a higher rate of erosions at baseline and at 1 year follow-up in comparison to other haplotypes. PMID: 24200909
6. This is the first report demonstrating that heterodimeric combinations of IL-2R and IL-6R subunits are functional for signaling. PMID: 23926072
7. MiniSTR marker D22S1045 (locus 22q12.3) is localized near the breakpoint region of the Ewing Sarcoma gene, but was found to be neutral related to EWS in a case-control study analyzing allele frequencies and linkage disequilibrium. PMID: 24112992
8. Suggest that oxalate-induced activation of the renal IL-2Rbeta pathway may lead to a plethora of cellular changes, the most common of which is the induction of inflammation. PMID: 24523387
9. Data indicate that both CgammaCR-CD127(+)composed of Interleukin-7 (IL-7) tethered to IL-7Ralpha/CD127, and CgammaCR-CD122(+) CD8(+) T((E/CM)) engraft in mice and persist in an absence of exogenous cytokine administration. PMID: 23628622
10. Data suggest that cross-talk occurs between cAMP/PKA and the IL-2R beta/Jak3/Stat5b cascade in T-cells. PMID: 23341462
11. Single nucleotide polymorphism in IL2RB is associated with lung cancer. PMID: 22573796
12. The researchers found evidence that there were significant differences between the D22S1045 locus in the Maghreb population and other populations. PMID: 21674833
13. Genetic variants of IL2RB may be associated with the development of acute rejection episodes and may help predict risk in kidney transplantation patients. PMID: 21839273
14. LTR of the THE1D retroelement family has been domesticated as an alternative promoter of human IL2RB, the gene encoding the beta subunit of the IL-2 receptor. PMID: 21865161
15. Lyn coimmunoprecipitates with the interleukin-2 beta receptor and JAK3 proteins in human T-cell leukemia virus type 1-infected T-cells. PMID: 21345943
16. IL-15R alpha, which bears most of the binding affinity for IL-15, behaves as a potent IL-15 agonist by enhancing its binding and biological effects through the IL-15R beta/gamma heterodimer. PMID: 16284400
17. Data show that co-expression of ZNF300 and Egr1 lead to enhanced IL-2Rbeta promoter activity, and suggest that ZNF300 is another regulator of the human IL-2Rbeta promoter. PMID: 20585888
18. IL-2Rbeta is subject to ectodomain shedding generating an intracellular fragment biologically functional, because (i) it is phosphorylated, (ii) it associates with STAT5A, and (iii) it increases cell proliferation. PMID: 20495002
19. Alternate signalling pathways from the interleukin-2 receptor PMID: 11750878
20. Here we show, in four cell lines of human adult T cell lymphoma/leukemia origin, that the three IL-2R subunits are compartmented together with HLA glycoproteins and CD48 molecules in the plasma membrane PMID: 11856346
21. SHB links IL2 receptor for signal transduction and mediates apoptosis PMID: 12200137
22. Peptide p1-30, which is composed of the 30 amino-terminal residues of human interleukin-2, binds as a tetramer to the dimeric IL-2Rbeta2 receptor PMID: 12676936
23. The development of breast tumour is associated with an increased expression of IL-2 receptor beta and this expression also seems to be associated with the malignancy of the tumour. PMID: 14680494
24. Cultures in the presence of peptide epitopes to this receptor inhibited T cell proliferation. PMID: 15350462
25. Interleukin-2 receptor beta-627*C homozygote and C allele correlate with higher susceptibility to endometriosis. PMID: 16084898
26. location of the G245R polymorphism next to the proximal cytokine receptor homology segment; suggestive of a genetic association with the development of visceral leishmaniasis. PMID: 17108990
27. these results indicate that precise sorting of IL-2Rbeta from early to late endosomes is mediated by Hrs, a known sorting component of the ubiquitin-dependent machinery, in a manner that is independent of UIM-ubiquitin binding PMID: 18445679
28. study found PI3K & STAT5 signaling pathways are required for granulysin expression & IL-2Rbeta induction & IL-2Rbeta induction is a prerequisite for granulysin expression; both signaling pathways are defective in CD4+ T cells from HIV-infected patients PMID: 18490721
29. Report the selective expansion of genetically modified T cells using an antibody/IL2RB receptor chimera. PMID: 18589435
30. High serum IL-2R level is associated with peripheral T-cell lymphoma, unspecified. PMID: 18592269
31. The uncleaved 12-kDa form of p12(I) resides in the ER and interacts with the beta and gamma(c) chains of the interleukin-2 receptor (IL-2R), the heavy chain of the major histocompatibility complex (MHC) class I, as well as calreticulin and calnexin. PMID: 18791162
32. the preformed complexes between gamma c and IL-2Rbeta or IL-9Ralpha promote signaling by the JAK3 A572V mutant without ligand, identified in several human cancers. PMID: 18829468
33. The C627T polymorphism in the IL2RB gene is not associated with risk of endometriosis in Korean women. PMID: 19602517

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HGNC: 6009

OMIM: 146710

KEGG: hsa:3560

STRING: 9606.ENSP00000216223

UniGene: Hs.474787