Recombinant Human Killer cell immunoglobulin-like receptor 2DS4 (KIR2DS4)

1. KIR2DS4 was associated with significant reduced incidence of relapse of hematological malignancies after hematopoietic stem cell transplantation from matched sibling PMID: 28993188
2. KIR2DS4, KIR2DS1, and some alleles of KIR2DS5 contribute to successful pregnancy suggests that activation of uNK cells by KIR binding to HLA-C is a generic mechanism promoting trophoblast invasion into the decidua. PMID: 27815424
3. Our findings suggest that KIR2DS4*00101 may offer a molecular biomarker to identify intrinsically milder forms of glioblastoma PMID: 27406829
4. Data indicate the allelic diversity of KIR2DS4 proteni among ethnic Hans from southern China, which may provide data for transplantation as well as studies on KIR-associated disease and evolution. PMID: 28186587
5. this study shows that the expression of full-length KIR2DS4 allele variants may contribute to a worse clinical outcome after hematopoietic stem cell transplantation PMID: 27998801
6. Type 1 pediatric autoimmune hepatitis patients show increased frequency of KIR2DS4-Full Length, which in combination with HLA-DRB1*1301 revealed a strong synergistic effect. Adult autoimmune hepatitis cases have shown a weaker increased frequency of KIR2DS4-FL, a lack of synergistic effect with HLA class II antigens. PMID: 26890333
7. Collectively, our data suggest that the KIR 2DS4/1D allelic variance is associated with the outcome of sibling-related HLA-matched HSCT, and that donor subclassification of KIR 2DS4/1D alleles should be considered in this setting. PMID: 26476204
8. genetic polymorphism is associated with the course of Hepatitis C virus infection and the response to therapy PMID: 26206121
9. KIR2DS4 can induce the uptake of CCR7 by KIR2DS4(+) NKG2A(+) natural killer cell clones after interacting with CCR7(+) target cells expressing HLA-Cw4 and HLA-Cw6 alleles. PMID: 25961063
10. Study shows KIR3DL1 and KIR2DS4 gene variants are linked and that the gene KIR2DS5 is only present in the telomeric half of the KIR locus. Study revealed novel insights in the highly organized distribution of KIR genes. PMID: 25503311
11. These results highlight the impact of population allele frequency on viral control and identify a novel association between HLA-C04 : 01 in combination with KIR2DS4f and uncontrolled HIV infection. PMID: 25715101
12. KIR2DS4del presence in patients was associated with severity of endometriosis, which, due to strong negative linkage disequilibrium, may suggest an indirect effect of KIR2DS5 absence PMID: 25724317
13. Response of rheumatoid arthritis patients with medium ESR values to methotrexate treatment may be dependent on the full-length KIR2DS4 gene. PMID: 25069714
14. lower genotype frequency in children with systemic juvenile idiopathic arthritis PMID: 24112428
15. Possession of the functional and non-functional KIR2DS4 isoforms in the mother and the fetus determines the risk of the vertical HIV-1 transmission. PMID: 24239756
16. Our data revealed a unique contribution of activating KIRs (KIR2DS4, KIR2DS2, or KIR3DS1), in addition to NKG2C, in the expansion of human natural killer cells. PMID: 23325834
17. in response to HCT therapy, the activating receptors are also enhanced by a process that increases the number of unmethylated sites present on KIR2DS2/4 promoters. PMID: 22939905
18. Results suggest a protective role of KIR2DS5 in graft rejection and an association of KIR2DS4 with kidney rejection, particularly in recipients with glomerulonephritis. PMID: 23028591
19. KIR1D/KIR1D might play a key role in Treponema pallidum infection in Chinese Han population that belongs to KIR gene haplotype A. PMID: 22128817
20. The CMV seropositivity of donors was not associated with activating KIR expression, and donor null expression in those with the KIR2DS2 or KIR2DS4 genotype was not predictive for CMV reactivation in the recipient. PMID: 21596150
21. Data indicate that the increased frequency of CD8(+) effector-memory T cells with activating NKR KIR2DS4, NKG2C and NKG2D, and cytotoxicity toward hematopoietic cell lines suggests involvement in bone marrow failure and clonal expansion in PNH. PMID: 21554925
22. KIR2DS4*001, the only allele of KIR2DS4 known to encode a functional activating receptor, was associated with relatively high viral load for HIV-1 and with accelerated transmission of HIV-1 to cohabiting seronegative partners. PMID: 21216870
23. significant association of full-length KIR2DS4 or KIR2DL1/3DL1 expression with the occurrence of acute graft vs host disease in hematopoietic stem cell transplantation PMID: 20062104
24. Data revealed that the trend of parasitic positive individuals to be KIR3DL1/KIR3DS1 heterozygous in pair with KIR2DS4 nondeleted variants in a set of KIR genes inheritable as the AB genotypes. PMID: 19859704
25. KIR2DS4 interacts with a non-class-I MHC protein on melanomas. This interaction is both specific & functional. Site-directed mutagenesis shows that the AAs involved in recognizing this novel ligand are different from those interacting with HLA-Cw4. PMID: 15265913
26. KIR 2DS4 may be a risk factor for susceptibility to RA in Taiwan. PMID: 16641046
27. The presence of KIR1D in the absence of KIR2DS4*001 was detected significantly more frequently in Chronic Myeloid Leukemia PMID: 18463675
28. Determination of the crystallographic structure of KIR2DS4 shows two major differences from KIR2DL: displacement of contact loop L2 and altered bonding potential because of the substitutions at positions 71 and 72. PMID: 19858347

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HGNC: 6336

OMIM: 604955

KEGG: hsa:3809

UniGene: Hs.654608