Recombinant Human Melatonin receptor type 1A (MTNR1A)

1. we provide evidence that decreased expression of MTNR1A (MT1 ) in the liver of diabetic individuals is associated with poorly controlled diabetes PMID: 29247541
2. polymorphic genotypes of rs6553010 of MTNR1A might contribute to the ability to predict aggressive phenotypes of UCC. This is the first study to provide insights into risk factors associated with intronic MTNR1A variants in the clinicopathologic development of UCC in Taiwan. PMID: 29104467
3. There were no statistically significant differences in the distribution of MTNR1A rs2119882 and MTNR1B rs4753426 genotypes and alleles between women with gestational diabetes and healthy pregnant women. PMID: 28084098
4. One single nucleotide polymorphism (SNP), rs713224, located near the brain-expressed melatonin receptor (MTNR1A) gene, was associated with the somatic complaints domain of depression symptoms. [Meta-Analysis] PMID: 26997408
5. findings suggest that a variant near MTNR1A may be associated with job-related exhaustion in shift workers PMID: 28364478
6. By integrating genetic and epigenetic data, we identified that a differentially methylated CpG site within the melatonin receptor 1A (MTNR1A) gene mediates the effect of a paternally transmitted genetic variant on the comorbidity of asthma and AR. This study provides a novel insight into the role of epigenetic mechanisms in patients with allergic respiratory diseases. PMID: 27038909
7. MT1 is part of the presynaptic protein network and negatively regulates Cav 2.2 activity, providing a first hint for potential synaptic functions of MT1. PMID: 26514267
8. rs2119882 polymorphism was associated with polycystic ovary syndrome in Han Chinese. A significant difference in transmission of allele C of rs2119882 was found between obese and non-obese women with PCOS. PMID: 26519818
9. results support gene-environment interactions of MTNR1A polymorphisms with smoking and betel quid-chewing habits possibly altering oral-cancer susceptibility and metastasis PMID: 25806809
10. Sections from paraffin-embedded normal tissue from 42 individuals, representing the different parts of the GI tract (n=39) and pancreas (n=3) were studied with immunohistochemistry using antibodies for melatonin, MT1 and MT2 receptors and serotonin. PMID: 25822611
11. There were no significant differences between the expression of MT1 and histological type, staging, grading, presence of residual disease, or overall survival time. PMID: 25514412
12. Suggest that physiological regulation of the melatonin receptors may result from complex and subtle mechanisms, a small difference in affinity between the active and inactive states of the receptor, and spontaneous coupling to G-proteins. PMID: 24117008
13. genetic polymorphisms rs2119882 in melatonin receptor 1A (MTNR1A) and rs10830963 in melatonin receptor 1B (MTNR1B) are associated with an increased risk of developing gestational diabetes mellitus and insulin resistance in Han Chinese women PMID: 24157813
14. this study provides a detailed delineation of the melatonin-mediated activation of ERK1/2 in HEK293 cells that are transfected with melatonin receptor MT1. PMID: 24724723
15. MR-1A placental expression is elevated in all types of hypertensive syndromes in pregnancy PMID: 23725077
16. Genetic inactivation of both transgenic MT1 and MT2 receptors produces an increase of wakefulness, likely as a result of reduced NREMS due to the lack of MT2 transgene receptors, and reduced REMS induced by the lack of MT1 transgene receptors. PMID: 23333399
17. MT1 negative TNBC in all cases regardless of race showed a significantly higher hazard ratio for disease progression, shorter progression free survival, and disease-related death, and shorter OS. PMID: 23250547
18. MT1 and MT2 expression is significantly reduced in preeclamptic compared with normotensive pregnancy placentas. PMID: 22686298
19. intracytoplasmic positivity for the MTNR1A receptor in the excretory ducts of human major and minor salivary glands and Warthin's tumor was found PMID: 23155241
20. Description of the constitutive activity of cloned human melatonin receptors hMT(1) and hMT(2) and discovery of inverse agonists. PMID: 22017484
21. Data indicate that melatonin receptors MT1 and MT2 expression levels decreased in both early and advanced stages of tumors in males. PMID: 21809392
22. Results suggest that common genetic variation in the MTNR1a and 1b genes may contribute to breast cancer susceptibility, and that associations may vary by menopausal status. PMID: 22138747
23. Single nucleotide polymorphisms in the melatonin receptor 1A gene is associated with calcium nephrolithiasis. PMID: 21652546
24. Data found a splice site mutation in ASMT (IVS5+2T>C) and one stop mutation in MTNR1A (Y170X) - detected exclusively in patients with ADHD - for which biochemical analyses indicated that they abolish the activity of ASMT and MTNR1A. PMID: 21615493
25. The finding suggests a synergism effect between the unfavourable genotype (CT) of the MELIA receptor SNP and the vascular disease in this subgroup of patients. PMID: 21635358
26. Results suggest that MTNR1A may be a susceptibility gene for schizophrenia and may be associated with insomnia symptoms exhibited in schizophrenia patients. PMID: 21526376
27. The single nucleotide polymorphism rs2119882 is associated with polycystic ovary syndrome PMID: 21474908
28. the decreased expression of MT1 in human colorectal cancer could point to a role of melatonin in this disease. PMID: 22217986
29. This study delineated a pathologic process whereby mutant htt-induced loss of the mitochondrial MT1 receptor enhances neuronal vulnerability and potentially accelerates the neurodegenerative process. PMID: 21994366
30. piRNA_015520 negatively regulates MTNR1A gene expression by binding to its genomic region PMID: 21818375
31. Melatonin protects human spermatozoa from apoptosis via melatonin receptor- and extracellular signal-regulated kinase-mediated pathways. PMID: 21497337
32. Melatonin has a modulating effect on dopaminergic neurotransmission in the brain. PMID: 20726823
33. Study identified six non-synonymous mutations for MTNR1A and ten for MTNR1B in autism spectrum disorders patients . The majority of these variations altered receptor function. PMID: 20657642
34. Immunohistochemical analysis revealed that during tooth development Mel1aR was expressed in secretory ameloblasts, the cells of the stratum intermedium and stellate reticulum, external dental epithelial cells, odontoblasts, and dental sac cells. PMID: 20372918
35. The results demonstrate a down-regulation of melatonin receptors in regions affected by Parkinson disease, suggesting their possible involvement in the disease process. PMID: 20110911
36. MT1 receptor is a major transducer of melatonin's actions in the breast, suppressing mammary gland development and mediating the anticancer actions of melatonin through multiple pathways. PMID: 20050373
37. Increased melatonin 1a-receptor immunoreactivity in the hippocampus of Alzheimer's disease patients. PMID: 11841602
38. Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer (melatonin receptor 2) PMID: 11940583
39. Melatonin inhibited ERalpha mRNA expression & enhanced induction of pancreatic spasmolytic polypeptide in MT(1)-transfected breast cancer cells, suggesting a role for the MT(1) receptor in melatonin-regulated growth-suppression & gene-modulation. PMID: 12088876
40. Expression in cultured skin cells. PMID: 12767050
41. Identification of variants in the human melatonin receptor could provide a useful tool for testing the gene in the predisposition to various other melatonin-related disorders and for clarifying the role of melatonin in adolescent idiopathic scoliosis. PMID: 12973153
42. the first evidence for the presence of MT1 receptor in human gallbladder epithelia; might be involved in the regulation of gallbladder function PMID: 14675129
43. The colocalization of MT1 and CRH suggests that melatonin might directly modulate the hypothalamus-pituitary-adrenal axis in the PVN, which may have implications for stress conditions such as depression PMID: 17072839
44. Human osteoblasts expressed melatonin 1a receptor and its expression levels decreased gradually with the age of the hosts. PMID: 17349020
45. on the abundant expression of MT1-mRNA in human bone tumors and osteosarcoma cells lines suggest an important role for MT1 in bone pathology PMID: 17645699
46. Luzindole also stimulates downregulation of the MT1 receptor protein, interfering with the synthesis and/or degradation of the receptor PMID: 17803522
47. Truncation of the C-terminal tail of both receptors (MT(1)Y7.64 and MT(2)Y7.64) inhibited internalization as well as the cAMP response, suggesting the importance of the C-terminal tail in these receptor functions. PMID: 18341518
48. MUPP1 binds to the G protein-coupled MT(1) melatonin receptor and directly regulates its G(i)-dependent signal transduction PMID: 18378672
49. MTNR1A is the most likely target for epigenetic silencing at 4q35 and to play a pivotal role during oral carcinogenesis. PMID: 18452558
50. Promoter polymorphism of the MTNR1A gene was not associated with the occurrence or curve severity of adolescent idiopathic scoliosis. PMID: 18794763

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HGNC: 7463

OMIM: 600665

KEGG: hsa:4543

STRING: 9606.ENSP00000302811

UniGene: Hs.243467