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  4. Recombinant Human Mitochondrial folate transporter/carrier (SLC25A32)

Recombinant Human Mitochondrial folate transporter/carrier (SLC25A32)

  • 货号：
    CSB-CF872477HU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    SLC25A32
  • Uniprot No.：
  • 别名：
    SLC25A32; MFT; MFTC; Mitochondrial folate transporter/carrier; Solute carrier family 25 member 32
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-315
  • 氨基酸序列
    MTGQGQSASGSSAWSTVFRHVRYENLIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRP KYNGILHCLTTIWKLDGLRGLYQGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEA TEYLVSAAEAGAMTLCITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVR GLYKGFVPGLFGTSHGALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVA ATYPYQVVRARLQDQHMFYSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVY ENVSHFLLDLREKRK
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transports folate across the inner membranes of mitochondria. Can also transport FAD across the mitochondrial inner membrane.
  • 基因功能参考文献：
    1. These data demonstrate that the loss of functional Slc25a32 results in cranial neural tube defects (NTDs) in mice and has also been observed in a human NTD patient. PMID: 29666258
    2. A novel SLC25A32 homozygous variant is associated with severe neuromuscular phenotype. PMID: 28443623
    3. SLC25A32 gene polymorphism could be a risk factor for lower folate concentration and future fracture. PMID: 24354357
    4. identified residues in the walls and at the base of the transport cavity that are involved in substrate recognition by the MFT PMID: 21768094
    5. Patient with SLC25A32 deficiency was able to have a successful pregnancy after fertilization in vitro. PMID: 19362304

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  • 相关疾病：
    Exercise intolerance, riboflavin-responsive (RREI)
  • 亚细胞定位：
    Mitochondrion inner membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Mitochondrial carrier (TC 2.A.29) family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 29683

    OMIM: 610815

    KEGG: hsa:81034

    STRING: 9606.ENSP00000297578

    UniGene: Hs.532265