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  4. Recombinant Human Neuropeptide S receptor (NPSR1)

Recombinant Human Neuropeptide S receptor (NPSR1)

  • 货号：
    CSB-CF757818HU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    NPSR1; GPR154; GPRA; PGR14; Neuropeptide S receptor; G-protein coupled receptor 154; G-protein coupled receptor PGR14; G-protein coupled receptor for asthma susceptibility
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-371
  • 氨基酸序列
    MPANFTEGSFDSSGTGQTLDSSPVACTETVTFTEVVEGKEWGSFYYSFKTEQLITLWVLF VFTIVGNSVVLFSTWRRKKKSRMTFFVTQLAITDSFTGLVNILTDINWRFTGDFTAPDLV CRVVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGEKQARVLIVIAWSLSFLFSIP TLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLTIISIMYGIVIRTIWIK SKTYETVISNCSDGKLCSSYNRGLISKAKIKAIKYSIIIILAFICCWSPYFLFDILDNFN LLPDTQERFYASVIIQNLPALNSAINPLIYCVFSSSISFPCREQRSQDSRMTFRERTERH EMQILSKPEFI
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    G-protein coupled receptor for neuropeptide S (NPS). Promotes mobilization of intracellular Ca(2+) stores. Inhibits cell growth in response to NPS binding. Involved in pathogenesis of asthma and other IgE-mediated diseases.
  • 基因功能参考文献：
    1. A decreased risk of psychological stress was only found in TT of NPSR1 (rs324981): A allele carriers vs. TT genotype (OR 1.64, 95% CI 1.11, 2.42), and AT genotype vs. TT genotype (OR 1.76, 95% CI 1.17, 2.65). We found that the NPSR1 (rs324981) T/T genotype decreased the risk of psychological stress, while the overall coping style was a risk factor for psychological stress. PMID: 30242809
    2. Results show higher fronto-limbic connectivity in adolescent A allele carriers vs. children carrying the A allele, a pattern which could not be discerned in TT homozygotes. Adolescent NPSR1 TT risk genotype carriers vs. adolescent A allele carriers displayed a reduced fronto-amygdala and fronto-insula effective connectivity suggesting basis of risk-increasing effect of the NPSR1T allele for anxiety. PMID: 26503268
    3. Sequence variation in NPSR1 may contribute to sex differences in stress regulation. PMID: 27883964
    4. we have utilized a broad-scaled affinity proteomics approach to identify three proteins (CCL5, HPGDS, and NPSR1) with altered plasma levels in asthmatic children compared to healthy controls, representing the first evaluation of HPGDS and NPSR1 in plasma. PMID: 27145233
    5. The interaction between 5-HTT (LL) and BDNF (A+) increased the risk of anxiety, and the interaction between BDNF (A+, GG) and NPSR1 (AA, T+) increased the risk of depression in asthmatic patients. PMID: 27176146
    6. findings demonstrate that hNPS-(1-10) is a biased agonist favoring Galphaq-dependent signaling. It may represent a valuable chemical probe for further investigation of the therapeutic potential of human NPS receptor-directed signalingin vivo. PMID: 26865629
    7. anxiety sensitivity correlated negatively with prefrontal activity in NPSR1 rs324981 carriers possibly suggesting a decompensation of the adaptive compensatory upregulation PMID: 25971599
    8. Results suggest the functional NPSR1 gene A/T variant to influence glutamate+glutamine concentrations in the bilateral anterior cingulate cortex in healthy male subjects during CCK-4 induced panic PMID: 26235955
    9. The T-allele of the NPSR1 rs324981 polymorphism is associated with increased impulsivity and ADHD-related traits in non-clinical cohorts. PMID: 25744621
    10. The results suggest neuropeptide S receptor gene variation to be associated with alterations of prefrontal functioning in the attentional functions alerting and executive control partly modulated by anxiety sensitivity. PMID: 25842293
    11. Results show that NPSR1 polymorphism is associated with AUD and alcohol consumption, dependent on sex, environment and age. PMID: 24754478
    12. gene polymorphism is a risk factor for high IgE-associated atopic eczema at the age of two years in Finland if there is no probiotic treatment PMID: 24439655
    13. The functional SNP rs324981 located in the gene of NPSR1 was significantly associated with objectively obtained sleep parameters in a sample of elderly white subjects PMID: 24896296
    14. results suggest a potential protective function of the NPSR1 rs324981 A/A genotype against pathologically enhanced anxiety that might be explained by stronger reflective prefrontal regulation over the subcortical fear response. PMID: 23103692
    15. Genetic variation at the NPSR1 locus impacts children's predisposition to ecurrent abdominal pain episodes in a Swedish population. PMID: 25091462
    16. study provides first evidence for the assumption that a NPSR1 variant modulates brain activation under stress, interacting with the environmental risk factor urban upbringing PMID: 24800784
    17. In the Estonian population, NPSR1 A/T polymorphism together with environmental factors is associated with anxious, depressive and activity-related traits, increased prevalence of affective/anxiety disorders and a higher likelihood of suicidal behaviour. PMID: 24331455
    18. NPSR1 A/T polymorphism is associated with impulsivity, ADHD symptoms and personality, mirroring the activity- and anxiety-mediating role of NPSR1. PMID: 23325374
    19. Neuropeptide S receptor 1 (NPSR1) activates cancer-related pathways and is widely expressed in neuroendocrine tumors. PMID: 24915894
    20. Differential gene-environment effects of the NPSR rs324981 T allele indicate recent life events with respect to anxiety sensitivity. PMID: 22404660
    21. NPS receptor may have a pathological role in individuals with severe asthma and/or elevated serum IgE levels. PMID: 24239856
    22. The present data demonstrated that QA1 and PI1 act as potent NPSR antagonists in vitro, however their usefulness for in vivo investigations in mice seems limited probably by pharmacokinetic reasons. PMID: 23911665
    23. Relate NPSR1 genotype to early onset obsessive-compulsive disorder. PMID: 23680103
    24. The results of this study showed involvement of the NPS system in the regulation of the neuroendocrine stress response in humans. PMID: 23466585
    25. RORA SNPs are associated with childhood asthma and show epistasis with NPSR1, and the interaction between RORA and NPSR1 may be of biological relevance. PMID: 23565190
    26. In summary, the more active NPSR1 T allele may confer enhanced response inhibition and increased error monitoring and might drive particularly error monitoring as a neurophysiological endophenotype of anxiety PMID: 23319044
    27. NPS is able to stimulate human monocyte chemotaxis and that this effect is entirely due to selective NPSR activation. PMID: 23142110
    28. DNA methylation levels in the promoter of NPSR1 showed small but significant associations with asthma and to related traits such as allergy and certain environmental exposures. PMID: 23372674
    29. we consider NPSR as a promising target for antipsychotic drug development PMID: 22078257
    30. analysis of molecular evolution of the neuropeptide S receptor and cross-species comparison PMID: 22479518
    31. NPSR1 gene is associated with reduced risk of rheumatoid arthritis. PMID: 22548958
    32. findings represent a first step to decipher NPSR1 locus complexity and its impact on several human conditions NPS antagonists have been recently described, and our results are of potential pharmacogenetic relevance PMID: 22216302
    33. Ther neuropeptide S receptor genotype is associated with increased amygdala responsiveness to fear-relevant stimuli. PMID: 21525857
    34. results provide converging evidence for a female-dominant role of NPSR gene variation in panic disorder through heightened autonomic arousal and distorted processing of anxiety-relevant emotional stimuli. PMID: 20603625
    35. There is an NPSR1 isoform-specific link to pathogenetic processes in asthma and allergy. PMID: 21707994
    36. data suggest a genetic and neuroanatomical substrate for catastrophizing overinterpretations of fear reactions. PMID: 20628342
    37. The available information regarding NPS and its receptor and the biological actions modulated by the NPS-NPSR system, is summarized. PMID: 19824051
    38. NPS-NPSR1 signaling is likely involved in anxiety PMID: 20705147
    39. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20701904
    40. Data show that NPSR1 polymorphism may be relevant to RA susceptibility and its clinical manifestation. PMID: 20179762
    41. Observational study of gene-disease association. (HuGE Navigator) PMID: 19913121
    42. Observational study of gene-disease association. (HuGE Navigator) PMID: 20603625
    43. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20628086
    44. Observational study of gene-disease association. (HuGE Navigator) PMID: 20628342
    45. Observational study of gene-disease association. (HuGE Navigator) PMID: 20705147
    46. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    47. Observational study of gene-disease association. (HuGE Navigator) PMID: 20503287
    48. Results suggest that N-linked glycosylation is not important for neuropeptide S receptor biogenesis or function, and that residue D105 might be critical for receptor binding. PMID: 19874863
    49. Observational study of gene-disease association. (HuGE Navigator) PMID: 20179762
    50. Expression of several neuropeptides is induced upon NPS-NPSR1 signaling; NPSR1 variants are associated with colonic transit in functional gastrointestinal diseases PMID: 19732772

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  • 相关疾病：
    Asthma-related traits 2 (ASRT2)
  • 亚细胞定位：
    [Isoform 1]: Cell membrane; Multi-pass membrane protein.; [Isoform 3]: Cell membrane; Multi-pass membrane protein.; [Isoform 4]: Cell membrane; Multi-pass membrane protein.; [Isoform 2]: Cytoplasm.; [Isoform 5]: Cytoplasm.; [Isoform 6]: Cytoplasm.; [Isoform 7]: Cytoplasm.; [Isoform 9]: Cytoplasm.
  • 蛋白家族：
    G-protein coupled receptor 1 family, Vasopressin/oxytocin receptor subfamily
  • 组织特异性：
    Isoform 4 is ubiquitous; it is detected in glandular epithelia of bronchus, stomach, small intestine, colon, uterus, esophagus, spleen, kidney, pancreas, prostate and breast. Isoform 1 is detected in uterus, colon and prostate, and in the smooth muscle ce
  • 数据库链接：

    HGNC: 23631

    OMIM: 608584

    KEGG: hsa:387129

    STRING: 9606.ENSP00000352839

    UniGene: Hs.652373