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  4. Recombinant Human Neuropeptides B/W receptor type 1 (NPBWR1)

Recombinant Human Neuropeptides B/W receptor type 1 (NPBWR1)

  • 货号：
    CSB-CF015972HU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    NPBWR1; GPR7; Neuropeptides B/W receptor type 1; G-protein coupled receptor 7
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-328
  • 氨基酸序列
    MDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLY VLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNT FSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLD DEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAK ALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANS CLNPFLYAFLDASFRRNLRQLITCRAAA
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals. Has a higher affinity for neuropeptide B.
  • 基因功能参考文献：
    1. screening of GPR7 gene mutations among lean and obese subjects revealed a Tyr135Phe allelic variant that is fairly common in the study population. This variant is unlikely to cause a functional derangement of the receptor PMID: 23563248
    2. hypermethylation of HIST1H4F, PCDHGB6, NPBWR1, ALX1, and HOXA9 was significantly associated with shorter survival in stage 1 Non-small-cell lung cancer PMID: 24081945
    3. A single nucleotide polymorphism of NPBWR1 changed the receptor function of this molecule at the cellular level, and, at the behavioral level, could influence personality difference in the context of social interaction. PMID: 22545105
    4. neuropeptide B, a neuropeptide modified with bromine is an endogenous ligand for GPR7 PMID: 12118011
    5. distribution in central nervous system and peripheral tissues with precursor peptides PMID: 12401809
    6. characterization of a family of endogenous neuropeptide ligands for this G protein-coupled receptor PMID: 12719537
    7. These results suggest a relationship between the pathogenesis of inflammatory/immune-mediated neuropathies, GPR7 receptor expression, and pain transmission. PMID: 15607941
    8. Expressed in the zona glomerulosa and zona fasciculata-reticularis ( cells of the human adrenal cortex. PMID: 15797961
    9. methylation of the GPR7 is significantly associated with prostate cancer prognosis. PMID: 17437806

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Found in cerebellum and frontal cortex. Detected at high levels in hippocampus, amygdala and trachea; at moderate levels in fetal brain, pituitary gland and prostate. Not in caudate, accumbens, kidney or liver. Also detected at high levels in lung carcino
  • 数据库链接：

    HGNC: 4522

    OMIM: 600730

    KEGG: hsa:2831

    STRING: 9606.ENSP00000330284

    UniGene: Hs.248117