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  4. Recombinant Human Reactive oxygen species modulator 1 (ROMO1)

Recombinant Human Reactive oxygen species modulator 1 (ROMO1)

  • 货号：
    CSB-CF020063HU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    ROMO1
  • Uniprot No.：
  • 别名：
    ROMO1; C20orf52; Reactive oxygen species modulator 1; ROS modulator 1; Epididymis tissue protein Li 175; Glyrichin; Mitochondrial targeting GxxxG motif protein; MTGM; Protein MGR2 homolog
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length of mature protein
  • 表达区域：
    2-79
  • 氨基酸序列
    MPVAVGPYGQSQPSCFDRVKMGFVMGCAVGMAAGALFGTFSCLRIGMRGRELMGGIGKTM MQSGGTFGTFMAIGMGIRC
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.; Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.
  • 基因功能参考文献：
    1. Romo1 overexpression was associated with poor response to treatment and shorter survival in advanced NSCLC patients treated with platinum-based chemotherapy. Romo1 could be a potential adverse predictive marker in this setting. PMID: 27188201
    2. Increased Romo1 expression was found to be associated with high lymph node ratio. Cancer invasiveness appeared to be a key reason for the poor survival related to highly expressed Romo1 PMID: 28472059
    3. the diagnostic sensitivity and specificity of serum reactive oxygen species modulator 1 were only 41.38% and 86.21%, respectively, with the cutoff value of 27.22 ng/mL. The sensitivity and specificity of pleural fluid carcinoembryonic antigen were 69.23% and 88.00%, respectively, at the cutoff value of 3.05 ng/mL, while serum carcinoembryonic antigen were 80.77% and 72.00% at the cutoff value of 2.60 ng/mL. PMID: 28459208
    4. elevated in pleural effusion when lung cancer present PMID: 28121949
    5. The rs6060566 polymorphism of the Romo-1 gene was found to be an independent risk factor for DR in Caucasians with T2DM. PMID: 25824963
    6. Genetic polymorphisms of Romo1 gene were associated with significant risk of gastric cancer. PMID: 25374412
    7. These results demonstrate that tumor cell invasion in response to oxidative stress is associated with Romo1 expression and the NF-kappaB signaling pathway. PMID: 25673177
    8. Results demonstrate that expression of Romo1 is frequently upregulated in human glioblastomas and its elevation promotes malignant tumor progression by promoting cell cycle progression and by enhancing tumorigenicity PMID: 25193023
    9. Increased Romo1 expression in surgically resected NSCLC was found to be significantly associated with early recurrence and poor survival. Romo1 overexpression could be a potential adverse prognostic marker in this setting. PMID: 25468147
    10. Serum Romo1 discriminated NSCLC patients from the population without cancer with considerable sensitivity and specificity. Serum Romo1 could be a potential diagnostic biomarker for NSCLC. PMID: 24951318
    11. High ROMO1 expression is associated with Fanconi anemia. PMID: 25687884
    12. Romo1 may be a principal regulatory factor in the maintenance of constitutive NF-kappaB activation in tumor cells PMID: 25044121
    13. that ROS modulator protein 1 (ROMO1) links ROS and mitochondrial morphology and ultrastructure by modulating cristae remodeling and mitochondrial fusion PMID: 24473193
    14. data identify ROMO1 as a critical molecular switch that couples metabolic stress and mitochondrial morphology, linking mitochondrial fusion to cell survival. PMID: 24473195
    15. This study is the first to demonstrate that strict modulation of DKK1 expression in different cell types partially maintains cell survival via tight regulation of the ROS-producing ROMO1 and radiation resistance. PMID: 24269823
    16. Romo1 mediates mitochondrial reactive oxygen species production and apoptosis induced by oxidative stress in lung epithelial cells. PMID: 23867822
    17. A 19 amino acid peptide (pCM19) at positions 42-60 of hGlyrichin is crucial for its antibacterial activity. PMID: 22083756
    18. Romo1 expression induced by Myc during G1 phase stimulates Skp2-mediated Myc degradation in a negative-feedback mechanism PMID: 21558421
    19. increased Bcl-XL expression, which is observed in many cancer cells, confers resistance to oxidative stress in the cancer cells by suppressing Romo1-mediated oxidative stress. PMID: 21399876
    20. Romo1 and Bcl-X(L)) are directly associated with TNF-alpha-induced ROS production. Romo1 is a molecular bridge between TNF-alpha signaling and the mitochondria for ROS production that triggers TNF-alpha-mediated apoptosis. PMID: 20203691
    21. Romo1-derived reactive oxygen species play an important role in apoptotic cell death triggered by withdrawal of cell survival factors. PMID: 19904609
    22. Mitochondrial ROS generated by Romo1 expression are required for normal cell proliferation. Romo1 plays an important role in redox signalling during normal cell proliferation. PMID: 19513905
    23. Results suggest that MTGM is an integral mitochondrial inner-membrane protein that coordinately regulates mitochondrial morphology and cell proliferation. PMID: 19535734
    24. cellular adaptive response to Romo1-induced ROS is a mechanism of drug resistance to 5-FU PMID: 17537404
    25. The results of this study suggest that Romo1-induced ROS may play an important role in redox signaling in cancer cells. PMID: 18313394
    26. age-related ROS levels increase, and this contributes to replicative senescence, which is directly associated with Romo1 expression. PMID: 18836179

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  • 亚细胞定位：
    Mitochondrion inner membrane; Single-pass membrane protein.
  • 蛋白家族：
    MGR2 family
  • 组织特异性：
    Up-regulated in a number of cancer cell lines when compared to a normal lung fibroblast cell line. Highly expressed in brain tumors.
  • 数据库链接：

    HGNC: 16185

    KEGG: hsa:140823

    STRING: 9606.ENSP00000338293

    UniGene: Hs.472564