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  4. Recombinant Human Receptor-binding cancer antigen expressed on SiSo cells (EBAG9)

Recombinant Human Receptor-binding cancer antigen expressed on SiSo cells (EBAG9)

  • 货号：
    CSB-CF007355HU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    BAG9; Cancer associated surface antigen; Cancer associated surface antigen RCAS1; Cancer-associated surface antigen RCAS1; EB9; EBAG 9; EBAG9; Estrogen receptor binding fragment associated gene 9 protein; Estrogen receptor binding site associated antigen 9; estrogen receptor binding site associated; antigen; 9; Estrogen receptor-binding fragment-associated gene 9 protein; PDAF; RCAS 1; RCAS1; RCAS1_HUMAN; Receptor binding cancer antigen expressed on SiSo cells; Receptor-binding cancer antigen expressed on SiSo cells
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-213
  • 氨基酸序列
    MAITQFRLFKFCTCLATVFSFLKRLICRSGRGRKLSGDQITLPTTVDYSSVPKQTDVEEWTSWDEDAPTSVKIEGGNGNVATQQNSLEQLEPDYFKDMTPTIRKTQKIVIKKREPLNFGIPDGSTGFSSRLAATQDLPFIHQSSELGDLDTWQENTNAWEEEEDAAWQAEEVLRQQKLADREKRAAEQQRKKMEKEAQRLMKKEQNKIGVKLS
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    10xHis-SUMO-tag
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.
  • 基因功能参考文献：
    1. Data suggest that joint detection of receptor-binding cancer antigen expressed on SiSo cells (RCAS1) and carcinoembryonic antigen (CEA) can improve the diagnostic sensitivity and specificity. PMID: 26438059
    2. RCAS1 seems to be involved in creating tumor-induced inflammation in the tumor and its microenvironment PMID: 25773455
    3. High EBAG9 expression is associated with malignant pleural effusion in patients with lung cancer. PMID: 24720371
    4. Findings suggest that the histological effect of increased RCAS1 expression depends on its cellular source and that RCAS1 expression itself is a component of various signaling pathways in urothelial bladder cancer cells. PMID: 25674852
    5. suggests that RCAS1 has an apoptotic function via membranous/soluble expression pattern in OSCC cells. RCAS1 may thus affect tumor escape from immune surveillance in OSCC by inducing apoptosis PMID: 24885040
    6. RCAS1 could be a useful immunohistochemical biomarker, indicating not only tumor aggressiveness but also a poorer prognosis for patients with NSCLC. PMID: 24815841
    7. High EBAG9 expression is associated with tamoxifen resistance in breast cancer. PMID: 24119785
    8. sRCAS1 levels could have a clinical value for the diagnosis and management of lung cancer and could be used as a new tumor marker of lung cancer. PMID: 23881387
    9. RCAS1 may play an important role in the phenomenon of tumor escape from host immunological surveillance and in creating the immune tolerance for the tumor cells, as well as in the tumor microenvironment. PMID: 23164108
    10. The membrane molecule RCAS1 induces immune cell apoptosis via the RCAS1-RCAS1R pathway. PMID: 23563217
    11. The intensity of the suppressive profile of the cervical cancer microenvironment indicated by the presence of both RCAS1 and B7H4 on the front of the tumor and in the macrophages and fibroblasts infiltrating the cancer stroma PMID: 22530960
    12. RCAS1 protein may participate in thyroid neoplastic transformation and could be considered as a useful biomarker to improve diagnostic scrutiny. PMID: 22460085
    13. The immunoreactivity of RCAS1 on the cells present in the ovarian cancer microenvironment, was analysed. PMID: 21845402
    14. Data suggest that RCAS1 may be involved in the early stages of tumor progression in mobile tongue squamous cell carcinoma. PMID: 21804460
    15. We observed a statistically significant increase in the RCAS1-positive macrophage infiltration within the microenvironment of the molar lesions in patients with partial hydatidiform mole in comparison with those who exhibited complete hydatidiform mole. PMID: 20645939
    16. analyzed RCAS-1 as a biomarker in the serum of patients with head and neck squamous cell carcinoma PMID: 20571277
    17. EBAG9 acts as a negative regulator of a COPI-dependent ER-to-Golgi transport pathway in epithelial cells and shows pathogenetic principle in which interference with intracellular membrane trafficking results in the emergence of a tumor-associated glycome PMID: 20570965
    18. RCAS1 can be used as a serum tumor marker for diagnosis of pancreatic cancer. PMID: 19957811
    19. the RCAS1 putative receptor-expressing chronic myelogenous leukemia cell line K562 was co-cultured with SiSo, MCF-7, or soluble RCAS1 to follow RCAS1 secretion in apoptosis initiation PMID: 20079734
    20. NASP and RCAS1 proteins were more frequently expressed in ovarian cancer tissues than with normal ovarian tissue and serous cystadenomas and MRE11 was less frequently expressed PMID: 20164540
    21. Overrepresentation of EBAG9 may play a specific role in early stages of breast carcinogenesis. PMID: 11705872
    22. High expression of tumor-associated antigen RCAS1 in pancreatic ductal adenocarcinoma is an unfavorable prognostic marker PMID: 11992411
    23. RCAS1 is associated with ductal breast cancer progression PMID: 12054692
    24. modulates surface expression of tumor-associated, normally cryptic O-linked glycan structures and contributes indirectly to the antigenicity of tumor cells PMID: 12672804
    25. RCAS1 expressed on macrophages may play an important role in the induction of activated T-cell apoptosis in cases of HNL PMID: 12774924
    26. Overexpression of EBAG9 is correlated with advanced pathologic stages of prostate cancer PMID: 12845666
    27. RCAS1 may have role endometrial cancer invasiveness; overexpression associated with significantly poorer prognosis PMID: 12888828
    28. RCAS1 gene or protein expression may not correlate with tumor progression in esophageal squamous cell carcinoma PMID: 14534714
    29. The mean survival of patients who had primary hepatocellular carcinoma with high RCAS1 protein expression was significantly longer than that of patients with low expression. PMID: 14981953
    30. wide distribution of EBAG9 and its relation to advanced disease suggest that this protein may play important roles in epithelial ovarian cancer PMID: 15164121
    31. RCAS1 expression might be associated with progression of oral squamous cell carcinoma PMID: 15254686
    32. Serum RCAS1 appears to be valuable as a diagnostic index for biliary carcinomas, as well as for evaluating the progression of cancers during therapy. PMID: 15460847
    33. EBAG9 and Snapin have roles in controlling exocytosis processes PMID: 15635093
    34. Macrophages may negatively regulate erythropoiesis at least in part through the production of RCAS1 molecules. PMID: 15813909
    35. EBAG9 is a crucial regulator of tumor progression and a potential prognostic marker for RCC. PMID: 15867365
    36. the estrogen-inducible EBAG9 gene-product and the 22-1-1 defined antigen are structurally and functionally separate antigens PMID: 15904507
    37. RCAS1 expression is informative for the follow-up of malignant mesothelioma patients and sRCAS1 in pleural fluid may be useful for the diagnosis of malignant mesothelioma. PMID: 16012715
    38. RCAS1 may contribute to acquisition of malignant uterine cervical phenotypic characteristics including invasion, metastasis, and tumor growth via connective tissue remodeling. PMID: 16112176
    39. RCAS1 and CAP may play a role in the downregulation of the maternal immune response during pregnancy and may participate in the initiation of the labor PMID: 16113565
    40. distribution of RCAS1 expression in normal female genital organs; significant positive correlation between age and RCAS1 expression; RCAS1 may affect metaplastic processes and tumor progression PMID: 16175077
    41. expression of RCAS1 is correlated with recurrence not only in carcinomas, but also in mesenchymal tumors PMID: 16211275
    42. metastatic lymph nodes from bile duct, gastric, colon and pancreatic cancer were investigated for RCAS1 expression PMID: 16273616
    43. RCAS1 expression in gliomas may play roles in tumor progression and tumor immune escape. PMID: 16595162
    44. The expression of RCAS1 by endometrial cells may favor the persistence of these cells in ectopic localization both in scar following cesarean section and in ovarian endometriosis. PMID: 16907986
    45. Significantly higher RCAS1 expression was noticed in tumor in comparison to stroma in patients with the presence of lymph nodes metastases. No such difference was observed in patients without the metastases. PMID: 17187007
    46. RCAS1 expression was simultaneous to the infiltration of activated immunological cells of tumor environment as well as decidua. The activity of immunological cells was selectively suppressed. PMID: 17187008
    47. High-level expression of RCAS1 is involved in the malignant transformation of endometrium, and RCAS1 coexpression with ER-alpha may be associated with development and metastasis of endometrial carcinoma PMID: 17466050
    48. The expression of RCAS1 in cervical cancer is significantly increased, and has correlation with malignant degree of cervical carcinoma. Some RCAS1-positive cervical cancer tissues are infected by HPV16. PMID: 17562271
    49. possible role of the RCAS1 protein in the development of pre-eclampsia through an immunological pathway. PMID: 17604121
    50. the drop of the RCAS1 level, which could be a result of an insufficiency of the compensatory immune response mechanisms in tubal mucosa (although these mechanisms are simultaneously preserved in endometrium), leads to tubal perforation. PMID: 17717421

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  • 亚细胞定位：
    Golgi apparatus membrane; Single-pass type III membrane protein. Note=According to PubMed:10426319, it also exists as a soluble form which has the same biological activities. The existence of such soluble form is however uncertain.
  • 组织特异性：
    Widely expressed. Expressed in ovary, testis, prostate, thymus, muscle and heart, but not in small intestine, colon, lymph nodes, or peripherical blood lymphocytes. The protein is not detected in any of the above organs.
  • 数据库链接：

    HGNC: 3123

    OMIM: 605772

    KEGG: hsa:9166

    STRING: 9606.ENSP00000337675

    UniGene: Hs.409368