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  4. Recombinant Human Retinoic acid receptor responder protein 1 (RARRES1)

Recombinant Human Retinoic acid receptor responder protein 1 (RARRES1)

  • 货号：
    CSB-CF019341HU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    RARRES1
  • Uniprot No.：
  • 别名：
    RARRES1; PEIG1; TIG1; Retinoic acid receptor responder protein 1; Phorbol ester-induced gene 1 protein; PERG-1; RAR-responsive protein TIG1; Tazarotene-induced gene 1 protein
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-294
  • 氨基酸序列
    MQPRRQRLPAPWSGPRGPRPTAPLLALLLLLAPVAAPAGSGDPDDPGQPQDAGVPRRLLQQAARAALHFFNFRSGSPSALRVLAEVQEGRAWINPKEGCKVHVVFSTERYNPESLLQEGEGRLGKCSARVFFKNQKPRPTINVTCTRLIEKKKRQQEDYLLYKQMKQLKNPLEIVSIPDNHGHIDPSLRLIWDLAFLGSSYVMWEMTTQVSHYYLAQLTSVRQWKTNDDTIDFDYTVLLHELSTQEIIPCRIHLVWYPGKPLKVKYHCQELQTPEEASGTEEGSAVVPTELSNF
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inhibitor of the cytoplasmic carboxypeptidase AGBL2, may regulate the alpha-tubulin tyrosination cycle.
  • 基因功能参考文献：
    1. TIG1 interacted with DNAJC8 in the cytosol, and this interaction completely blocked DNAJC8-mediated PKM2 translocation and inhibited glucose uptake. Furthermore, increased glycose uptake was observed in cells in which TIG1 was silenced. PMID: 29902837
    2. Data demonstrated that RARRES1 expression is lost in choriocarcinoma tumors due to promotor hypermethylation. Also, further results hypothesized that RARRES1 might be a negative regulator of EMT through induction of contact inhibition. PMID: 29169400
    3. Data show that retinoic acid receptor responder 1 (RARRES1) expression is subtype-dependent and regulated by DNA methylation and the expression of aldehyde dehydrogenase 1A3 (ALDH1A3). PMID: 27286452
    4. Data suggest that Retinoic Acid Receptor Responder (RARRES1)/ Tazarotene-induced gene-1 (TIG-1) may serve as a target for therapeutic intervention both in cancer and in angiogenesis-related disorders. PMID: 28678839
    5. s found that transmembrane protein 192 (TMEM192) interacted with TIG1. s also found that both TIG1A and TIG1B isoforms interacted and co-localized with TMEM192 in HtTA cervical cancer cells. The expression of TIG1 induced the expression of autophagy-related proteins. PMID: 27989102
    6. All-trans retinoic acid modulated secretion of RARRES1 in a dose dependent manner. PMID: 22942771
    7. our data suggested that epigenetic silencing of TIG1 gene expression by promoter hypermethylation may play an important role in hepatocellular carcinoma . PMID: 24006221
    8. High TIG1 expression is associated with inflammatory breast cancer through activation of Axl kinase. PMID: 24014597
    9. Analysis of a standard liver fibrosis model (CCl(4)) demonstrated an early induction of RARRES1 mRNA and protein expression. PMID: 22669512
    10. genotype-associated hypermethylation of the ETS-family target gene RARRES1 influences methylation at its neighbor gene LXN and could be useful as a prognostic biomarker. PMID: 22573467
    11. Knocking-down CTCF expression hampered RARRES1 expression. PMID: 22615834
    12. TIG1 suppressed PGE2-stimulated Wnt and cAMP signaling pathways in colon cancer cells through GRK5. PMID: 22126303
    13. GRK5 mediates cell growth suppression by TIG1A. Thus, TIG1 may participate in the downregulation of G-protein coupled signaling by upregulating GRK5 expression. PMID: 21575264
    14. The results of this study suggested that short RAI1 alleles might be releated to schizophreina disease. PMID: 21168224
    15. RARRES1, its interacting partners AGBL2, Eg5/KIF11, another EEY-bearing protein (EB1), and the microtubule tyrosination cycle are important in tumorigenesis. PMID: 21303978
    16. Silencing of TIG1 promoter by hypermethylation is common in human cancers and may contribute to the loss of retinoic acid responsiveness in some neoplastic cells. PMID: 15059893
    17. Hypermethylation of tazarotene-induced gene 1 is associated with gastric carcinogenesis PMID: 16134180
    18. TIG1 overexpression in SASC inhibited their differentiation into osteocytes and the expression of osteocalcin PMID: 19250291
    19. Findings suggest that TIG1 may play a role in cellular proliferation and invasion in NPC cells and that its function may be dependent on the EBV status. PMID: 19737656
    20. TIG1 undergoes frequent epigenetic inactivation due to aberrant DNA hypermethylation in gastric cancers. PMID: 19806788

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  • 亚细胞定位：
    Membrane; Single-pass type III membrane protein.
  • 蛋白家族：
    Protease inhibitor I47 (latexin) family
  • 数据库链接：

    HGNC: 9867

    OMIM: 605090

    KEGG: hsa:5918

    STRING: 9606.ENSP00000237696

    UniGene: Hs.131269