Recombinant Human Small conductance calcium-activated potassium channel protein 3 (KCNN3)

1. SK3 expression was strongly reduced in the Hirschsprung disease patient intestines, both in the ganglionic and aganglionic bowel, compared to the control intestines. PMID: 29439660
2. this is the first report to associate KCNN3 with poor prognosis and drug resistance in ovarian cancer (OC). The present findings indicated that KCNN3 is a potential prognostic marker and therapeutic target for OC. PMID: 29901154
3. Data indicate that the inhibition of the Store Operated Calcium Entry (SOCE)-dependent colon cancer cell migration through SK3/TRPC1/Orai1 channel complex by the alkyl-lipid Ohmline may be a strategy to modulate Anti-EGFR mAb action in metastatic colorectal cancer (mCRC). PMID: 27102434
4. A splice variant SK3.2 was found in ventricular myocyte mitochondria and its mRNA expression was studied. PMID: 28342809
5. Analyses of tissue microarray from colorectal cancer patients showed higher SigmaR1 expression levels in cancer samples and a correlation with tumor grade. Moreover, the exploration of a cohort of 4937 breast cancer patients indicated that high expression of SigmaR1 and Orai1 channels was significantly correlated to a lower overall survival PMID: 28114279
6. Edelfosine is able to effectively inhibit migration and invasion of UC cells in vitro and in vivo in an SK3-dependent way, pointing towards a possible role for Edelfosine as an antiinvasive drug to effectively inhibit UC cell invasion and metastasis. PMID: 26619845
7. KCNN3 gene encodes small conductance calcium-activated potassium (SK) channel 3 PMID: 26658685
8. Decreased SK3 expression in ganglionic bowel may explain the basis of persistent bowel symptoms in some patients following a properly performed pull-through operation for Hirschsprung's disease. PMID: 25783396
9. KCNN3 single-nucleotide polymorphism rs13376333 significantly increases the risk of Atrial Fibrillation. PMID: 26370375
10. There was no significant difference in the genotype distributions or allele frequencies of the SNP rs1131820 between AF patients and controls. PMID: 24978901
11. SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx. PMID: 25730848
12. Reduced SK3 expression attenuates endometrial cell migration and is associated with unsuccessful pregnancy outcomes. PMID: 24978672
13. Intermediate conductance Ca2+-activated K+ channels modulate human placental trophoblast syncytialization. PMID: 24595308
14. SK3 channel is activated in neuroblastoma cells by overexpression of human endogenous retrovirus W family envelope gene. PMID: 23727510
15. Atrial miR-499 is significantly upregulated in AF, leading to SK3 downregulation and possibly contributing to the electrical remodeling in AF. PMID: 23499625
16. study shows SK3 channels are localized in CD34(+) cells and not in smooth muscle cells and that expression of SK3 channels is higher in non-pregnant compared to pregnant myometrium; propose SK3 activators reduce myometrium contractility by modulating telocyte function; first report to provide evidence for possible role of SK3 channels in uterine telocytes PMID: 22947283
17. Specific expression of hSK3 led to deficits in attention and sensory gating and heightened sensitivity to a psychomimetic drug PMID: 24206670
18. Maternal association with preterm birth was found in small conductance calcium activated potassium channel isoform 3 (KCNN3, rs883319; P=0.01 PMID: 23018797
19. CaMKK/Akt/p300 cascade plays an important role in laminar stress-dependent induction of KCa2.3 and KCa3.1 expression, thereby regulating EC function and adaptation to hemodynamic changes. PMID: 23792675
20. We found that the SK3 channel triggers an association with the Orai1 channel within lipid rafts in primary human tumors and bone metastases PMID: 23774210
21. Two conserved arginine residues from the SK3 potassium channel outer vestibule control selectivity of recognition by scorpion toxins. PMID: 23511633
22. SK3-mediated [Ca(2+)]i elevation and membrane potential hyperpolarization in trophectoderm cells are important for blastocyst hatching. PMID: 22416006
23. A total of four intronic single nucleotide polymorphisms in the KCNN3 gene display significant association with migraine. PMID: 22030984
24. There is a significant association of rs13376333 in KCNN3 on chromosome 1q21 with atrial fibrillation in a Taiwanese population. PMID: 22019810
25. There is an association between the synonymous single-nucleotide polymorphism rs1131820 in KCNN3 and lone atrial fibrillation. PMID: 21398315
26. The longer polyglutamine stretches are associated with reduced conductance of KCNN3 channel. PMID: 21433290
27. Six SNPs (rs1218585, rs4845396, rs12058931, rs1218568, rs6426985, and rs4845394) in KCNN3 were associated with pretem birth. PMID: 21266667
28. Oxaliplatin-neurotoxicity may be related to distribution of the polymorphic CAG motif of the SK3 gene, which might modulate nerve after-hyperpolarization. The 13-14 CAG repeat allele could mark patients susceptible to acute OXA neurotoxicity. PMID: 20872144
29. This study suggests that the SNPs within the kccn3 genes we examined do not play a major role in schizophrenia in the Han Chinese PMID: 20933057
30. analysis of recycling of the Ca2+-activated K+ channel, KCa2.3, is dependent upon RME-1, Rab35/EPI64C, and an N-terminal domain PMID: 20360009
31. rs13376333 is intronic to KCNN3, which encodes a potassium channel protein involved in atrial repolarization. PMID: 20173747
32. Membrane hyperpolarization increases melanoma cell motility via the KCa2.3 channel. The KCa2.3 channel might be the only member of the Ca(2+)-activated K(+) channel family involved in melanoma cell motility pathways. PMID: 19646982
33. The hSKCa3 potassium channel gene contains polymorphic CAG repeats in the coding region and is involved in the regulation of neuronal activity. The longer repeat alleles of the hSKCa3 gene may contribute to the genetic susceptibility to AN. PMID: 11803450
34. results do not support the involvement of the hKCa3 gene in schizophrenia, at least in the Japanese population (hKCa3; a calcium-activated potassium channel gene) PMID: 11807415
35. the combined effect of long CAG repeats and the differences in allele sizes contribute to symptom expression of schizophrenia, particularly on the anergia-activation-paranoid axis PMID: 12007452
36. Kit-negative fibroblast-like cells express this channel in smooth gut muscle in health and dissease. PMID: 12457234
37. Decreased expression of SK3 channels in the aganglionic bowel may contribute to motility dysfunction in Hirschsprung's disease bowel. PMID: 12778407
38. novel SK3 transcript, SK3-1B that utilizes an alternative first exon (exon 1B), but is otherwise identical to SK3 and may contribute to pathogenesis of schizophrenia. PMID: 12808432
39. A contribution of the KCNN3 gene to genetic susceptibility to major psychosis and their phenotypic polymorphism may be related to the difference of allele length rather than to the number of CAG repeats. PMID: 12960745
40. the SK3 subunit of small conductance Ca2+-activated K+ channels interacts with both SK1 and SK2 subunits PMID: 14559917
41. SK3-1C is a dominant-negative suppressor of SKCa and IKCa channels PMID: 14638680
42. In this study a lower frequency for 1137-1140 Del homozygote of KCNN3 gene was observed, and the HHRR and TDT analyses suggested that the 1137-1140 Del alleles of KCNN3 gene be unlikely to confer susceptibility to schizophrenia. PMID: 16086287
43. Lack of evidence that length variations of the second polyglutamine array in the N-terminus of the KCNN3 channel exert an effect in migraine susceptibility. PMID: 16162291
44. The allelic frequency distribution of the CAG repeat in KCNN3 gene was compared in Serbian schizophrenic patients and controls. Data indicate a significant association between longer CAG repeats in second polymorphic KCNN3 region and schizophrenia. PMID: 16393881
45. The current work provides evidence for a fundamental role of the N-terminal domain and the calmodulin binding domain in SK3 trafficking in neurons. PMID: 17061167
46. Increased expression of SK3 has a critical role in the increased Ca(2+)-induced fragility in DM1 cells. PMID: 17101631
47. Endogenous ADMA may be an important factor for down-regulation of the expression of endothelial SK3 in atherosclerotic animals. PMID: 17869187
48. KCa3.1 and KCa2.3 are translocated out of the endoplasmic reticulum associated with Derlin-1. PMID: 18227067
49. No statistical association between the atrioventricular heart block phenotype and either the [CTG]n expansion length or the presence of specific single nucleotide polymorphisms in the SK3 gene were detected. PMID: 19472917

显示更多

收起更多

HGNC: 6292

OMIM: 602983

KEGG: hsa:3782

STRING: 9606.ENSP00000271915

UniGene: Hs.490765