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  4. Recombinant Human Steryl-sulfatase (STS)

Recombinant Human Steryl-sulfatase (STS)

  • 中文名称：
    人STS重组蛋白
  • 货号：
    CSB-CF022883HU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    STS
  • Uniprot No.：
  • 别名：
    STS; ARSC1; Steryl-sulfatase; Arylsulfatase C; ASC; Estrone sulfatase; Steroid sulfatase; Steryl-sulfate sulfohydrolase
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    22-583
  • 氨基酸序列
    HAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAA FMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSC HSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLA ALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLT QRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQ ILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGI LRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEF LFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPPL LFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPWLQL CCPSTGLSCQCDREKQDKRLSR
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid.
  • 基因功能参考文献：
    1. Polymorphisms of STS gene is associated with attention-deficit/hyperactivity disorder. PMID: 28367959
    2. STS is increased in preeclamptic placentas and maternal whole blood. Our data suggests that STS may affect sFlt1 secretion by regulating sFlt1-i13 transcription, and not via alterations in syncytialisation. PMID: 27871476
    3. This study reveals that STS is a key player of steroid biosynthesis regulating the availability of circulating cholesterol. PMID: 27531568
    4. In contrast to the situation in boys with ADHD, in healthy men, the G-allele at rs17268988 of STS is associated with enhanced cognition. PMID: 28293481
    5. miR-661 overexpression sensitized tumors to TRAIL or STS induced apoptosis in a xenograft mouse model, and these effects were attenuated by co-expression of CYC1. PMID: 28391262
    6. Collectively, STS point mutations demonstrate restricted localization, causing efficient impairment of the corresponding enzyme activity, and are more unlikely to be responsible for the phenotypic heterogeneity in XLRI subjects PMID: 26387488
    7. STS expression was not significantly associated with DFS and OS, despite positive STS expression in 27% of endometrial cancer patients. Therefore, the role of STS as a prognostic factor in patients with endometrial cancer remains unclear and requires further research. PMID: 26996578
    8. The induced STS facilitates the conversion of inactive estrogen sulfates to active estrogens, which in return attenuates the NF-kappaB-mediated inflammation. PMID: 26220752
    9. The antagonistic actions of glucocorticoids and NFkB on STS expression are similar to the regulation of inflammatory response proteins PMID: 26631368
    10. Letter/Case Report: novel nonsense mutation in the STS gene in X-linked ichthyosis. PMID: 26421812
    11. Data show that both estrogen sulfatase (STS) and estrogen sulfotransferase (EST) were highly expressed in the human umbilical vein endothelial cells (HUVECs). PMID: 26458420
    12. Effects of steroid hormone on estrogen sulfotransferase and on steroid sulfatase expression in endometriosis tissue and stromal cells PMID: 26723541
    13. represents one of the major pathways in regenerating biologically active steroids in both steroidogenic and nonsteroidogenic tissues [review] PMID: 26213785
    14. Our analyses show that the two phenotypes in our patient are due to independent genetic defects: a genomic rearrangement involving the Kallmann syndrome 1 gene and a point mutation of the steryl-sulfatase gene. PMID: 25726327
    15. In both arm and subumbilical skin biopsy of patients with idiopathic hirsutism, there was an up-regulation of STS mRNA expression. PMID: 26194504
    16. Genetic variation in ARSC may be associated with change in mammographic density after women stop using estrogen-progestin therapy. PMID: 25499601
    17. STS is present in human pre-osteoblastic bone cells and that it can influence bone cell growth PMID: 25042472
    18. complete deletion in Pakistani families with x-linked ichthyosis PMID: 24480088
    19. results suggest that steroid sulfatase expression can be decreased in the process of large intestinal carcinogenesis PMID: 23916543
    20. Data suggest that expression of STS and 17beta-hydroxysteroid dehydrogenase isoenzymes is up-regulated in subcutaneous abdominal fat of morbidly obese women as compared with morbidly obese men. PMID: 24081738
    21. Microdeletion within Xp22.3 containing STS with aCGH in an individual with suspected pre-Descemet corneal dystrophy and X-linked ichthyosis demonstrates the clinical utility of copy number variation analysis. PMID: 23807007
    22. IGF-II induces steroid sulfatase expression via a PI3-kinase/Akt-NF-kappaB signaling pathway in PC-3 cells and may induce estrogen production and estrogen-mediated carcinogenesis. PMID: 24055520
    23. Genetic variants in SULT2A1, PAPSS2, and STS do not predispose to polycystic ovary syndrome. PMID: 23861462
    24. no difference in placental activity found between women with polycystic ovarian syndrome and controls PMID: 23122578
    25. Genetic variants affecting steroid sulfatase expression and/or activity could influence the function of brain regions perturbed in attention deficit hyperactivity disorder (ADHD). PMID: 21255266
    26. Filaggrin defects can synergize with steroid sulfatase deficiency to exacerbate the ichthyosis phenotype. PMID: 21945601
    27. Recent results of STS and EST in several estrogen-dependent carcinomas, are summarised. PMID: 21073915
    28. This timely review concentrates on recent advances in steroid sulfatase research. PMID: 21693170
    29. Case Report: Report novel point mutation in the STS gene in a patient with X-linked recessive ichthyosis. PMID: 21530180
    30. Genetic variation in the STS gene may be implicated in ADHD susceptibility and one polymorphism may be associated with lower STS mRNA expression as well as being more prevalent in female ADHD homozygotes. PMID: 20862695
    31. Recessive X-linked ichthyosis is caused by a deficiency in steroid sulphatase (STS), whose gene has been located on the X chromosome. PMID: 20236202
    32. Six novel single nucleotide polymorphisms of the steroid sulfatase gene in a Japanese population. PMID: 20814163
    33. A significant increment of STS followed exemestane neoadjuvant therapy of postmenopausal ER-positive breast carcinoma. This may represent the compensatory response of breast carcinoma tissues to estrogen depletion. PMID: 20151319
    34. Both steroid sulfatase and filaggrin mutations are found in X-linked ichthyosis. PMID: 20149601
    35. Analysis of deletions indicates complex origin, apart from homologous recombination, of deletion mutants. PMID: 11844872
    36. in the human hair follicle, concentrates in the dermal papilla. PMID: 11886493
    37. Regulation of estrogen activity in human endometrium: effect of IL-1beta on steroid sulfatase activity in human endometrial stromal cells. PMID: 11996939
    38. data demonstrate that LNCaP prostate cancer cells contain a steryl sulfatase with properties similar to that found in human breast cancer cells PMID: 12231117
    39. The structure of this enzyme, purified from the microsomal fraction of human placentas, determined by x-ray crystallography. PMID: 12657638
    40. Levels of STS and estrogen sulfotransferase mRNA and activity may be significantly associated with degree of atherosclerotic changes in female aorta, which may be related to cytokines produced in situ, such as IL-1beta, in human atherosclerotic lesions. PMID: 14507642
    41. estrogen-dependent cell growth of the estrogen sulfatase-transfected cell clones was found to be abolished, due to the enhanced sulfoconjugation of estrogen PMID: 14556660
    42. Steroid sulfatase increases steroid acute regulatory protein expression level and stimulates steroid production. PMID: 14969586
    43. SSase is concentrated in lamellar bodies (LB), and secreted into the SC interstices, along with other LB-derived lipid hydrolases. There, it degrades CSO4, generating some cholesterol for the barrier PMID: 15009711
    44. Strong activity and mRNA expression of DHEAS desulfating STS was found, twice as high in cerebral neocortex than in subcortical white matter. Cerebral STS resembled the characteristics of the known placental enzyme PMID: 15056284
    45. Dehydroepiandrosterone blood levels are influenced by a steroid sulfatase polymorphism following acute resistance exercise. PMID: 15152080
    46. Gonadotropin-releasing hormone agonist (leuprolide)inhibits estrone sulfatase expression in cystic endometriosis in the ovary. PMID: 15302278
    47. Increased steroid sulfatase expression is associated with estrogen-dependent endometrial carcinomas PMID: 15355916
    48. Findings of steroid sulfatase localized in the cytoplasm of the cumulus cells and expression of STS mRNA suggest a local steroidal regulation mechanism in cumulus cells. PMID: 16084891
    49. Studies on the localization of steroid sulfatase were performed. PMID: 16399357
    50. Corticotrophin-releasing hormone (CRH) increased whereas alpha-helical CRH decreased the mRNA levels of STS, CYP19A1, and HSD17B1, the key enzymes for estrogen synthesis. PMID: 16467490

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  • 相关疾病：
    Ichthyosis, X-linked (IXL)
  • 亚细胞定位：
    Cytoplasmic vesicle, secretory vesicle, microneme membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Sulfatase family
  • 数据库链接：

    HGNC: 11425

    OMIM: 300747

    KEGG: hsa:412

    STRING: 9606.ENSP00000217961

    UniGene: Hs.522578