Recombinant Human Syndecan-2 (SDC2)

1. Methylation of SFRP1, SFRP2, SDC2, and PRIMA1 promoter sequences was observed in 85.1%, 72.3%, 89.4%, and 80.9% of plasma samples from patients with Colorectal cancer and 89.2%, 83.8%, 81.1% and 70.3% from adenoma patients, respectively. PMID: 28753106
2. Emerging roles of SDC2 in epithelial and mesenchymal cancer progression has been summarized. (Review) PMID: 28940845
3. data suggest that syndecan-2 induces extracellular shedding of E-cadherin and supports the acquisition of a fibroblast-like morphology by regulating MMP-7 expression in a colon cancer cell line PMID: 27270030
4. SDC2 is overexpressed in Leri's pleonosteosis. The minor allele of a missense SDC2 variant, p.Ser71Thr, could confer protection against systemic sclerosis. PMID: 24442880
5. In this review we considered the function of syndecan-2, the structure of syndecan-2 and its role in the formation of amyloid plaques. PMID: 25916113
6. Extracellular matrix proteins expression profiling in chemoresistant variants of the A2780 ovarian cancer cell line. PMID: 24804215
7. HIV matrix protein p17 is pro-fibrogenic through its interactions both with CXCR2 and syndecan-2 on activated HSCs PMID: 24736615
8. The results demonstrate the importance of PDZ-binding domain of syndecan-2 for controlling LFA-1 affinity and cell adhesion. PMID: 24662262
9. SDC2 expression was higher in skin melnaoma cells. It enhanced tyrosinase activity by increasing the membrane and melanosome localization of protein kinase CbetaII. UVB-induced up-regulation was required for UVB-induced melanin synthesis. PMID: 24472179
10. syndecan 2 shows no changes associated to histological grade of Prostate cancer PMID: 24424718
11. RhoA, but not RhoC was shown to be essential for the anchored phenotype of breast carcinoma cells that accompanied siRNA-mediated loss of syndecan-2. PMID: 24447566
12. RKIP, LOX and SDC2 are coordinately regulated and collectively encompass a prognostic signature for metastasis-free survival in ER-negative breast cancer patients PMID: 23975428
13. Taken together, these data suggest that IL-1alpha regulates extracellular domain shedding of syndecan-2 through regulation of the MAP kinase-mediated MMP-7 expression in colon cancer cells. PMID: 24613844
14. Clinical validation of SDC2 methylation in serum DNA by quantitative methylation-specific PCR demonstrated a high sensitivity of 87.0% (95% CI, 80.0% to 92.3%) in detecting cancers. PMID: 23747112
15. DNA from 4 HPV positive and 4 HPV negative fresh frozen primary HNSCC were subject to comprehensive genome-wide methylation profiling.Pathway analysis of 1168 methylated genes showed 8 signal transduction pathways (SDC2) of which 62% are hypermethylated. PMID: 23736812
16. Taken together, these results suggest that the extracellular domain of syndecan-2 regulates the interaction of HCT116 human colon carcinoma cells with fibronectin. PMID: 23333331
17. SDC-2 modulates TGFbeta2 transcriptional regulation via Smad2 signaling to facilitate fibrosarcoma cell adhesion. PMID: 23297089
18. The repression of syndecan-2 by Wnt/beta-catenin/TCF signaling contributes to the resistance of osteosarcoma cells to doxorubicin. PMID: 22550000
19. lower TCR/CD3 surface levels caused by syndecan-2 led to reduced TCR/CD3 responsiveness PMID: 22881146
20. MC1R regulates melanoma cell migration via inhibition of syndecan-2 expression. PMID: 22493442
21. SDC-2 is a novel (perineural) invasion-associated gene in PDAC which cooperates with K-ras to induce a more invasive phenotype. PMID: 22471946
22. Notch receptors control their own activity by inducing the expression of syndecan-2, which then acts to propagate Notch signaling by direct receptor interaction. PMID: 22437834
23. a specific glycochain is a receptor for dengue virus strain DEN2 16681 PMID: 22170634
24. the data suggest that MMP-7 directly mediates shedding of syndecan-2 from colon cancer cells. PMID: 22227189
25. Here the protein tyrosine phosphatase receptor CD148 is shown to be a key intermediary in cell adhesion to syndecan-2 extracellular domain, with downstream beta1 integrin-mediated adhesion and cytoskeletal organization. PMID: 21813734
26. syndecan-2 was expressed preferentially in basal cells in benign tissue. In prostate cancer samples, syndecan 2 was expressed in granular-cytoplasmic localisation. PMID: 21317913
27. HIV-1 p17 matrix protein interacts with heparan sulfate side chain of CD44v3, syndecan-2, and syndecan-4 proteoglycans expressed on human activated CD4+ T cells affecting tumor necrosis factor alpha and interleukin 2 production. PMID: 21482826
28. the cytoplasmic domain of syndecan-2 regulates colon cancer cell migration via interaction with syntenin-1. PMID: 21569759
29. The findings demonstrate that LRP1 and HSPG function in a cooperative manner to mediate cellular Abeta uptake and define a major pathway through which Abeta gains entry to neuronal cells. PMID: 21289173
30. syndecan-2 and syndecan-4 regulate the compensatory effect of TG-FN on osteoblast cell adhesion and actin cytoskeletal formation in the presence of RGD peptides. PMID: 21036168
31. RGD-independent cell adhesion via a tissue transglutaminase 2-fibronectin matrix promotes fibronectin fibril deposition and requires syndecan-4/2 and {alpha}5{beta}1 integrin co-signaling. PMID: 20929862
32. Results support a potential role for syndecan-2 in pancreatic carcinogenesis and cancer progression. Expression of syndecan-2 might serve as a prognostic marker. PMID: 20683009
33. Study results supported the potential role of SDC2 in prostatic carcinogenesis and cancer progression. PMID: 19786981
34. these results suggest that syndecan-2 regulates cell migration of colon carcinoma cells through Tiam1-dependent Rac activation in colon cancer cells. PMID: 19962968
35. syndecan's interactions with both CASK and neurofibromin are dependent on syndecan homodimerization. PMID: 20006588
36. Identification of integrin alpha(M)beta(2) as an adhesion receptor on human peripheral blood monocytes for Cyr61 and connective tissue growth factor: immediate-early gene products expressed in atherosclerotic lesions.(integrin alpha(M)beta(2)) PMID: 12036876
37. role in mediating adhesion and proliferation of colon carcinoma cells PMID: 12055189
38. Ezrin N-terminal domain binds to the syndecan-2 cytoplasmic domain with an estimated K(D) of 0.71 microM and without the requirement of other proteins PMID: 12860416
39. Mechanisms for the regulation of HSPG have been studied. PMID: 12860968
40. Interleukin-8 binds to syndecan-2 on vascular endothelial cells. PMID: 14527339
41. the HSPG T allele is a risk factor for the development of severe diabetic nephropathy in type 2 diabetic patients PMID: 14674716
42. Syndecan-2 induces osteoblastic cell apoptosis through the JNK/Bax apoptotic pathway and the cytoplasmic domain of syndecan-2 is required for this action. PMID: 15936998
43. the transmembrane domains are sufficient for inducing dimerization and transmembrane domain-induced oligomerization is crucial for syndecan-2 and syndecan-4 functions PMID: 16253987
44. molecular complex most likely to obstruct RACK1 for functional attachment at syndecan-2, as revealed in cells transfected with oncogenic ras PMID: 16997272
45. HSPGs are expressed on the membrane of myeloid leukemic cell lineages. PMID: 17035092
46. heparanase-1 expression and heparan sulphate proteoglycan degradation are induced by estradiol in human endometrium PMID: 17261577
47. these data suggested that both HSPG and CD81 are important for HCV entry. PMID: 17457918
48. HSPG modulation of BMP signaling in myositis ossificans cells is reported. PMID: 17516498
49. syndecan-2 acts as a suppressor for MMP-2 activation, causing suppression of metastasis PMID: 17623663
50. There are pronounced tubulointerstitial HSPG alterations in primary kidney disease, which may affect the inflammatory response. PMID: 18032547

显示更多

收起更多

HGNC: 10659

OMIM: 142460

KEGG: hsa:6383

STRING: 9606.ENSP00000307046

UniGene: Hs.1501