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  4. Recombinant Human T-cell surface glycoprotein CD1a (CD1A)

Recombinant Human T-cell surface glycoprotein CD1a (CD1A)

  • 货号：
    CSB-CF004889HU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    CD1A; T-cell surface glycoprotein CD1a; T-cell surface antigen T6/Leu-6; hTa1 thymocyte antigen; CD antigen CD1a
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    17-327
  • 氨基酸序列
    NADGLKEPLSFHVTWIASFYNHSWKQNLVSGWLSDLQTHTWDSNSSTIVFLCPWSRGNFSNEEWKELETLFRIRTIRSFEGIRRYAHELQFEYPFEIQVTGGCELHSGKVSGSFLQLAYQGSDFVSFQNNSWLPYPVAGNMAKHFCKVLNQNQHENDITHNLLSDTCPRFILGLLDAGKAHLQRQVKPEAWLSHGPSPGPGHLQLVCHVSGFYPKPVWVMWMRGEQEQQGTQRGDILPSADGTWYLRATLEVAAGEAADLSCRVKHSSLEGQDIVLYWEHHSSVGFIILAVIVPLLLLIGLALWFRKRCFC
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
  • 基因功能参考文献：
    1. CD1a expression is up-regulated by TSLP (thymic stromal lymphopoietin) at levels observed in the skin of patients with atopic dermatitis, and the response is dependent on PLA2G4A. PMID: 29273672
    2. In this review, s summarize the current knowledge about CD1 proteins, their structures, lipid-binding profiles, and roles in immunity, and evaluate the role of CD1 proteins in eliciting humoral immune response PMID: 28386696
    3. CD207(+)CD1a(+) cells are circulating in patients with active Langerhans cell histiocytosis, and TSLP and TGF-beta are potential drivers of Langerhans-like cells in vivo. PMID: 28847997
    4. CD1a+ CD11b+ macrophages and NK T-cells were found to be significantly increased in inflamed colons of ulcerative colitis patients. PMID: 27809916
    5. The findings suggest that PLA2 inhibition or CD1a blockade may have therapeutic potential for psoriasis. PMID: 27670592
    6. these observations suggest that CD99 is involved in the regulation of CD1a transcription and expression by increasing ATF-2. PMID: 27094031
    7. this study shows that CD1a drove the pathogenesis of poison-ivy dermatitis and psoriasis, and that CD1a-mediated skin inflammation was abrogated by CD1a-blocking antibodies, which highlights CD1a as a target for treatment of inflammatory skin diseases PMID: 27548435
    8. The data show that immunohistochemistry for CD1a and Hsp60 can be of help in differential diagnosis between Keratoacantomas and well-differentiated forms of squamous cell carcinomas. PMID: 26442925
    9. NDN and CD1A are novel prognostic methylation markers in patients with head and neck squamous carcinomas PMID: 26518708
    10. Findings suggest that dermal survivin+CD1a+ (CD1a antigen) cell infiltration may be a potential biomarker of systemic sclerosis skin lesions. PMID: 26419626
    11. plasma-derived lipids drive functional levels of CD1d expression. PMID: 26460687
    12. Studies indicate that many CD1 antigen-restricted T cells do not require foreign antigens for activation but instead can be activated by self-lipids presented by CD1. PMID: 26284469
    13. High CD1a-positive dendritic cell density is associated with improved disease-free survival in papillary thyroid carcinoma. PMID: 26073685
    14. the expression of WNT4, a Wnt ligand, and three targets of Wnt-ss-catenin transcription activation, namely, MMP7, cyclinD1 (CD1) and c-MYC in 141 penile tissue cores from 101 unique samples, were investigated. PMID: 25901368
    15. Studies indicate that the antigen-presenting molecules CD1 and MHC class I-related protein (MR1) display lipids and small molecules to T cells. PMID: 26388332
    16. The presence of CD1a(+) T-cells in all of the LCH lesions that we have studied to date warrants further investigation into their biological function to determine whether these cells are important in the pathogenesis of LCH PMID: 25343480
    17. A polymorphism in human CD1A is associated with susceptibility to tuberculosis. PMID: 24500401
    18. [review] Humans express both Group 1 (CD1a, CD1b and CD1c) and Group 2 (CD1d) CD1 molecules with nonredundant functions in response to the presentation of endogenous lipids. PMID: 24556395
    19. CD1a deficiency on in vitro-derived DCs was detected in 15% of study subjects. A common SNP in the 5' UTR of CD1a is associated with both low surface expression & mRNA levels. It directly regulates gene expression in a promoter-luciferase assay. PMID: 23858036
    20. Case Report: cutaneous-limited self-regressing S100 negative/CD1a positive histiocytosis. PMID: 23334517
    21. binding cavity of CD1a is largely preserved in the unliganded state because of persistent electrostatic interactions that keep the portal alpha-helices at a constant separation. PMID: 23677998
    22. Dysregulated CD1 profile in myeloid dendritic cells in CVID is normalized by IVIg treatment. PMID: 23766460
    23. Molecular mechanisms by which CD1a captures distinct classes of self- and mycobacterial antigens are reviewed. Review. PMID: 23468110
    24. these results reveal that CD1 expression is modified in MS and provide novel information on the regulation of lipid antigen presentation in myeloid cells. PMID: 22670773
    25. Saposins utilize two strategies for lipid transfer and CD1 antigen presentation PMID: 22331868
    26. allelic variation in CD1A does not play a major role in determining multifocal motor neuropathy susceptibility. PMID: 22003931
    27. In the intratumoral and peritumoral areas, the expression of CD1a, tryptase, and CD68 was significantly higher in papillary thyroid carcinoma than in thyroid adenomas. PMID: 22007938
    28. GM-CSF independent signaling directed toward the CD1a genome is important in Langerhans cell biology. PMID: 21900947
    29. In Guillain-Barre syndrome, an initially positive association study with polymorphism of CD1A and CD1E genes was not confirmed PMID: 21696499
    30. CD1A and CD1E polymorphisms contribute to the polygenic susceptibility to multiple sclerosis PMID: 21496400
    31. We do not believe that there is a role for CD1a immunohistochemistry in the differential diagnosis of perivascular epithelioid cell neoplasms. PMID: 21194729
    32. Accumulation of CD1a-positive Langerhans cells and mast cells in actinic cheilitis. PMID: 20890667
    33. CD1E and CD1A genes may be involved in networks which determine susceptibility to multiple sclerosis types RR-MS and PP-MS, respectively. PMID: 20954848
    34. The quantity of CD1a-positive Langerhans cells in the lesions of epidermodysplasia verruciformis patients was significantly lower than in normal skin. PMID: 19317050
    35. microsomal triglyceride transfer protein deficiency was associated with increased proteasomal degradation of group 1 CD1 molecules in human abetalipoproteinemia. PMID: 20592474
    36. The effect of transient stimulation of the canonical Wnt pathway in the differentiation potential of Lin(-)CD34(+) CD1a(-) human thymic progenitors, was analyzed. PMID: 19952356
    37. Data show high expression of CD86 and CD11C, moderate expression of CD1a and CD123, low levels of CD83 on dendritic cells after induction by GM-CSF and IL-4. PMID: 19257981
    38. Data show that the expression of CD1a and CD207 is markedly down-regulated in CA epidermis. PMID: 19426597
    39. The intracellular trafficking route of CD1a is essential for efficient presentation of lipid antigens that traffic through the early endocytic and recycling pathways. PMID: 20026739
    40. outstanding ability of Langerhans cells to mediate CD1a-dependent lipid antigen presentation and thus, Langerhans-cell-mediated skin immunity may involve T cell recognition of both peptide and lipid antigens. PMID: 12925210
    41. CD1a and langerin have roles in antigen presentation to T cells PMID: 14991068
    42. Review. CD1a on tumor-infiltrating dendritic cells may present immunogenic tumor-specific glycolipid antigens to T-cells. PMID: 15099564
    43. CD1a expression was detected on monocytes in the majority of sickle cell anemia patients, and was predominant in SDPunjab patients. PMID: 15556687
    44. structural study illustrates how a single chain lipid can be presented by CD1 and that the peptide moiety of the lipopeptide is recognized by the T cell receptor PMID: 15723809
    45. hypothesis that CD1-restricted T cells might be activated and home to target tissues involved in Hashimoto's thyroiditis and Graves' disease PMID: 15749918
    46. CD1a may be a novel biomarker for Barrett metaplasia and that its expression may help to predict the prognosis of this pathology. PMID: 15756258
    47. identified CD1a-, CD1b-, and CD1c-restricted T cells from normal human donors that induce cytolysis and secrete copious IFN-gamma in response to self-CD1 expressed on monocyte-derived dendritic cells PMID: 16272286
    48. In this study, we show that PTX can selectively block the expression of CD1a isoform during the differentiation of human monocytes into dendritic cells. PMID: 16598657
    49. In humans, CD1a-expressing antigen- presenting cells located close to the lymphatic vessels in the upper layers of the dermis may fulfill some of the roles previously ascribed to Langerhans cells. PMID: 16670277
    50. A 1000-base pair region upstream of CD1A translation start site is identified as necessary for CD1A proximal promoter activity. PMID: 17082618

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Membrane raft; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues.
  • 数据库链接：

    HGNC: 1634

    OMIM: 188370

    KEGG: hsa:909

    STRING: 9606.ENSP00000289429

    UniGene: Hs.1309