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  4. Recombinant Human T-cell surface glycoprotein CD1b (CD1B)

Recombinant Human T-cell surface glycoprotein CD1b (CD1B)

  • 货号：
    CSB-CF004890HU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    CD1B; T-cell surface glycoprotein CD1b; CD antigen CD1b
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    18-333
  • 氨基酸序列
    SEHAFQGPTSFHVIQTSSFTNSTWAQTQGSGWLDDLQIHGWDSDSGTAIFLKPWSKGNFSDKEVAELEEIFRVYIFGFAREVQDFAGDFQMKYPFEIQGIAGCELHSGGAIVSFLRGALGGLDFLSVKNASCVPSPEGGSRAQKFCALIIQYQGIMETVRILLYETCPRYLLGVLNAGKADLQRQVKPEAWLSSGPSPGPGRLQLVCHVSGFYPKPVWVMWMRGEQEQQGTQLGDILPNANWTWYLRATLDVADGEAAGLSCRVKHSSLEGQDIILYWRNPTSIGSIVLAIIVPSLLLLLCLALWYMRRRSYQNIP
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
  • 基因功能参考文献：
    1. polyclonal germline-encoded mycolyl lipid-reactive T cell receptors that recognize CD1b-glucose-6-O-monomycolate use relatively conserved molecular mechanisms PMID: 27807341
    2. the development of polyvalent complexes of CD1b proteins and carbohydrate backbones (dextramers) and their use in identifying CD1b autoreactive T cells from human donors. PMID: 26621732
    3. for isoforms CD1b through CD1e, our simulations show the near-complete collapse of the hydrophobic cavities in the absence of the antigen. This event results from the spontaneous closure of the binding domain entrance, flanked by two alpha-helices. PMID: 23677998
    4. Molecular mechanisms by which CD1b captures distinct classes of self- and mycobacterial antigens are reviewed. Review. PMID: 23468110
    5. Deciphering the role of CD1e protein in mycobacterial phosphatidyl-myo-inositol mannosides (PIM) processing for presentation by CD1b to T lymphocytes PMID: 22782895
    6. CD1b has a mechanism for presenting either two small or one large lipid, allowing presentation of antigens with an unusually broad range of chain lengths. PMID: 22087000
    7. a cognate mechanism whereby CD1b-glycolipid complexes bind to TCRs. PMID: 21807869
    8. The DC-SIGNlow/CD86high population is characterized by a reduced CD1b expression that correlates with a reduced iMtb-specific lymphocyte proliferation together with an enhanced mixed leukocyte reaction. PMID: 20212510
    9. gammadelta T cells recognize lipid A (LA) in a CD1b- or CD1c-restricted manner in first response against Gram-bacteria, while the interaction between TLR4 on gammadelta T cells and LA might strengthen the subsequent response of gammadelta T cells. PMID: 19948070
    10. Lipid length controls antigen entry into endosomal and nonendosomal pathways for CD1b presentation. PMID: 11938350
    11. Failure of trafficking and antigen presentation by CD1b in AP-3-deficient cells PMID: 12049721
    12. CD1b and CD1c show strong binding of nitrobenzoxadiazole (NBD)-labeled dialkyl-based ligands. PMID: 14551186
    13. model proposed in which saposin C exposes lipid antigens from intralysosomal membranes for loading onto CD1b PMID: 14716313
    14. Current crystal structure illustrates for the first time the binding of a natural bacterial lipid antigen to CD1b and shows how its novel structural features fit the CD1b molecule for its role in the immune response to intracellular bacteria. PMID: 14764708
    15. CD1b expression was detected on monocytes in the majority of sickle cell anemia patients, and was highly expressed in Sbeta thalassemia patients. PMID: 15556687
    16. Expression of DC-SIGN and CD1b in human leprosy. PMID: 15880118
    17. Endosomal acidification acts directly, rather than through enzymatic trimming, to insert lipids into CD1b. PMID: 16794581
    18. The data presented herein explain how the CD1b groove is preserved, and provide a rationale for the in vivo antigen-binding properties of CD1b. PMID: 16874306
    19. study proposes that ionic tethers act as molecular switches that respond to pH fluxes during endosomal recycling and regulate the conformation of the CD1 heavy chain to control the size and rate of antigens captured PMID: 18538591
    20. The crystal structure of an avian CD1 (chCD1-2) that shares common ancestry with mammalian CD1 from approximately 310 million years ago, was determined. PMID: 19004781
    21. mycobacterial lipids structural constraints governing binding to CD1b and generation of antigenic CD1b:lipid PMID: 19454700
    22. Group 1 CD1-restricted T cells participate in adaptive immune responses upon mycobacterial infection. PMID: 19808251

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.
  • 数据库链接：

    HGNC: 1635

    OMIM: 188360

    KEGG: hsa:910

    STRING: 9606.ENSP00000357150

    UniGene: Hs.1310