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  4. Recombinant Human herpesvirus 1 Protein UL20 (UL20)

Recombinant Human herpesvirus 1 Protein UL20 (UL20)

  • 货号：
    CSB-CF319870HWY
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    UL20
  • Uniprot No.：
  • 别名：
    UL20; Protein UL20
  • 种属：
    Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-222
  • 氨基酸序列
    MTMRDDLPLVDRDLVDEAAFGGEEGELPLEEQFSLSSYGTSDFFVSSAYSRLPPHTQPVF SKRVILFLWSFLVLKPLEMVAAGMYYGLTGRVVAPACILAAIVGYYVTWAVRALLLYVNI KRDRLPLSAPVFWGMSVFLGGTALCALFAAAHETFSPDGLFHFIATNQMLPPTDPLRTRA LGIACAAGASMWVAAADSFAASANFFLARFWTRAILNAPVAF
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays an essential role in egress of virus particles from the nucleus, cytoplasmic envelopment and virus-induced cell fusion. Forms a functional protein complex with gK and this interaction is absolutely essential for their coordinate intracellular transport, gK glycosylation, expression on host cell surface, and function. Together, they modulate gB-mediated virus-induced cell fusion and virion egress and therefore actively participate in these processes.
  • 基因功能参考文献：
    1. Absence of zinc finger protein GODZ affects primary and latent infection, as well as reactivation, in ocularly infected mice. The reduced virus infectivity is due to the absence of the GODZ interaction with HSV-1 UL20. These results strongly suggest that binding of UL20 to GODZ promotes virus infectivity in vitro and viral pathogenesis in vivo. PMID: 29187538
    2. binding of UL20 to GODZ in the Golgi apparatus regulates trafficking of UL20 and its subsequent effects on glycoprotein K localization and virus replication. PMID: 28724772
    3. These data show that efficient endocytosis of gD and gH/gL and their incorporation into mature virions relies upon the presence of the herpes simplex virus type 1 envelope proteins gM and the gK/pUL20 complex. PMID: 25746217
    4. UL20 protein and the amino terminus of gK physically interact with gB. PMID: 20573833
    5. gK and UL20p directly interact and that this interaction facilitates their TGN localization, an important prerequisite for cytoplasmic virion envelopment and egress. PMID: 15542677
    6. role in membrane fusion and virion de-envelopment PMID: 15596825
    7. UL20/gK are required and function prior to UL11 protein in virion cytoplasmic envelopment PMID: 17215291
    8. These results show that UL20p functions in cytoplasmic envelopment are separable from UL20 functions in UL20p intracellular transport, cell surface expression and virus-induced cell fusion. PMID: 17996071
    9. The amino terminus of UL20p interacted with the intracellular gK domain III amd this fusion protien serves important functions in the coordinate transport of UL20p and gK to the trans-Golgi network. PMID: 18434401

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  • 亚细胞定位：
    Virion. Host Golgi apparatus membrane; Multi-pass membrane protein. Host nucleus membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Alphaherpesvirinae UL20 family
  • 数据库链接：

    KEGG: vg:2703371