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  4. Recombinant Mouse 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (Srd5a1)

Recombinant Mouse 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (Srd5a1)

  • 中文名称：
    小鼠Srd5a1重组蛋白
  • 货号：
    CSB-CF721219MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Srd5a1
  • Uniprot No.：
  • 别名：
    Srd5a1; 3-oxo-5-alpha-steroid 4-dehydrogenase 1; SR type 1; Steroid 5-alpha-reductase 1; S5AR 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-255
  • 氨基酸序列
    MELDELCLLDALVYLEGFLAFVAFVGLQMVGSSYGRYSSQWSGRRVPARPAWFLQELPSM AWPLYECIRPAAARLGNLPNRVLLAMFLIHYVQRTLVFPVLIRGGKPTLLFTFVLAFLFC TLNGYLQSRYLSQFAVYAEDWVTHPCFLTGFALWLVGMVINIHSDHILRNLRKPGETGYK IPRGGLFEYVSSANYFGELVEWCGFALASWSLQGVVFALFTLCALFTRARQHHQWYLEKF EDYPKTRKILIPFLL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
  • 基因功能参考文献：
    1. Prostate 5aR1 levels were positively correlated with adjusted prostate most severe lesion scores. Downregulation of androgen receptor and 5alpha-reductase 2, along with upregulation of 5a-reductase 1 in tumors may promote prostatic intraepithelial neoplasia and prostate cancer development in TRAMP mice PMID: 28493878
    2. Exaggerated predisposition to metabolic disorders in female mice, compared with that seen in male mice, after disruption of 5alphaR1 suggests phenotypic changes may be underpinned by altered metabolism of glucocorticoids rather than androgens. PMID: 27647861
    3. the Srd5a1 gene modulates ethanol consumption in a sex-dependent manner that is also contingent upon ethanol access condition and concentration PMID: 25416204
    4. deletion of the Srd5a1 gene significantly decreased ethanol's anxiolytic effect in female mice, and chronic ethanol withdrawal severity was lower in female versus male mice PMID: 25355320
    5. transcription of srd5a1 in brain is regulated by environmental factor-induced cytosine methylation in the promoter region. PMID: 26314512
    6. The effects of deficiency or inhibition of S5AR1 on the risk of liver disease and insulin resistance in male rats and mice are reported. PMID: 25239636
    7. The deletion of Type One 5alpha-reductase among female mice attenuates reproductive responding during the estrous cycle. PMID: 24650589
    8. These studies showed that 5alphaR1 deletion accelerates the development of hepatic steatosis but may protect against the development of nonalcoholic fatty liver disease-related hepatocellular neoplasia. PMID: 24080367
    9. Thus, 5alpha-reductase may be required for the estrous cycle variations in affective behavior and 3alpha,5alpha-THP levels of female mice. PMID: 21946309
    10. results suggest that local steroid 5 alpha-reductase 1 messenger RNA expression in Withdrawal Seizure-Prone mouse brain may not change in parallel with local allopregnanolone content or withdrawal severity PMID: 21917407
    11. The aim of the present study was to investigate the role of 5alpha-reductase type 1 for bone mass using Srd5a1-/- mice. PMID: 21731732
    12. This study evaluates 5alpha-R type I and 3alpha-HSD mRNA expression level in mouse brain by using in situ hybridization. PMID: 16984997
    13. social isolation-induced increase of the contextual fear-conditioning response is associated with a marked (50%) down-regulation of 5-RI mRNA expression in the hippocampus, amygdala, and FC. PMID: 18391192
    14. Data suggests that in male mice after social isolation, expression of Srd5a1 mRNA is specifically down-regulated in glutamatergic pyramidal neurons. In socially isolated mice, this down-regulation may account for the appearance of behavioral disorders. PMID: 18003893

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  • 亚细胞定位：
    Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Steroid 5-alpha reductase family
  • 数据库链接：

    KEGG: mmu:78925

    STRING: 10090.ENSMUSP00000089097

    UniGene: Mm.451912