Recombinant Mouse Adenosine receptor A2b (Adora2b)

1. Obesity is related with a condition of colonic inflammation, leading to an increase of A2BR expression. A2BR, modulating the activity of excitatory tachykininergic nerves, participate to the enteric dysmotility associated with obesity. PMID: 28808842
2. these results suggest that A2BAR stimulation inhibits the activation of ERK1/2, p38 and NF-kappaB by RANKL, which suppresses the induction of osteoclast marker genes, thus contributing to the decrease in osteoclast cell-cell fusion and bone resorption activity. PMID: 29047264
3. the pivotal role of CXCR4- and CXCR7-inhibition in acute pulmonary inflammation, which depended on A2B-receptor signaling, is reported. PMID: 28542132
4. Adora2B stimulation promotes FGF2 and CXCL12 expression in FAP-positive melanoma-associated fibroblasts, contributing to the creation of a tumor-promoting microenvironment. PMID: 27590504
5. activation of adenosine A2B receptors on myeloid cells caused nociceptor hyperexcitability and promoted chronic pain via soluble IL-6 receptor trans-signaling. PMID: 27320922
6. findings suggest that hypoxia, through HIF1A, contributes to the development and progression of pulmonary fibrosis through its regulation of ADORA2B expression on alternatively activated macrophages, cell differentiation, and production of profibrotic mediators PMID: 28701304
7. It has been reported that signaling through hepatocellular Adora2b adenosine receptors dampens IR injury of the liver. PMID: 27404219
8. Diabetes resulted in an increased A2A/A2B receptor expression in coronary arteries which resulted in enhanced A2A/A2B-mediated increase in coronary flow observed in diabetic hearts. PMID: 26654777
9. A2B adenosine receptor-induced VEGF production and angiogenesis are involved in myeloid-derived suppressor cells in a mouse melanoma model PMID: 26317647
10. Angiotensin II stimulation alters vasomotor response to adenosine in mouse mesenteric artery: role for A1 and A2B adenosine receptors PMID: 26227882
11. our results suggest that intestinal epithelial Adora2b signaling provides protection during intestinal inflammation via enhancing mucosal barrier responses. PMID: 25850656
12. exposure of DCs to A2BR agonist facilitated gammadelta T cell activation, leading to augmented Th17 responses and progressive EAU development. PMID: 26147733
13. IFN-gamma priming of macrophages selectively prevents the induction of the A2bR in macrophages to mitigate sensitivity to adenosine and to prevent this regulatory transition. PMID: 26355158
14. These findings implicate that tissue-specific targeting of Adora2b seems to be desirable when using Adora2b agonists to prevent or treat myocardial ischemia. PMID: 26136425
15. alveolar epithelial A2B adenosine receptor signaling contributes to lung protection, and they implicate inhaled A2B adenosine receptor agonists in ALI treatment. PMID: 26188061
16. the adenosine A2b receptor was shown to be the only one of the adenosine receptors whose cardiac expression is induced by ischemia in both mice and humans and whose function is implicated in ischemic pre- or post-conditioning PMID: 24502579
17. activation of the ADORA2B on macrophages plays an active role in the pathogenesis of lung fibrosis and pulmonary hypertension PMID: 25318478
18. the A2B adenosine receptor (ADORA2B) is essential for adenosine-induced SphK1 activity in human and mouse normal and sickle erythrocytes in vitro PMID: 25587035
19. Findings support a potentially destructive role for A2BAR under intestinal ischemia/reperfusion and acute hypoxic conditions. PMID: 24966910
20. study implicates the A2bAR as a regulator of adipocyte differentiation and the A2bAR-KLF4 axis as a potentially significant modulator of adipose biology. PMID: 24928509
21. Thus, adenosine acts as a danger-associated molecular pattern (DAMP) that initiates helminth-induced type 2 immune responses through A2B adenosine receptor. PMID: 24629340
22. findings reveal that excess adenosine-mediated ADORA2B signaling underlies reduced penile PDE activity by decreasing PDE5 gene expression in a HIF-1alpha-dependent manner PMID: 24614760
23. CD73-dependent production of extracellular adenosine and endothelial Adora2b signaling protects kidney during diabetic nephropathy. PMID: 24262796
24. found that stimulation of A2B adenosine receptors suppressed free fatty acid-induced deleterious inflammatory and metabolic activation of macrophages PMID: 24194503
25. Studies of ventilator-induced lung injury revealed induction of the ADORA2B during ALI in vivo that was abolished following HIF inhibition or genetic deletion of Hif1a. PMID: 24391213
26. the A2B receptor signaling linked to up-regulation of pro-angiogenic factors in cardiac Sca-1(+)CD31(-) stromal cells is essential for overall improvement of cardiac recovery seen after their transplantation to the injured heart. PMID: 23827818
27. an important role of the A2B receptor-dependent upregulation of JunB in VEGF production and possibly other AP-1-regulated events. PMID: 24136993
28. blockade of ADORA2B attenuates the development of a pulmonary hypertension phenotype that correlates with reduced levels of hyaluronan (HA) deposition in vessels and down-regulation of genes involved in synthesis of HA PMID: 23855769
29. Data suggest that crosstalk pathway between ENT2 and alveolar epithelial Adora2b in lung protection during acute lung injury (ALI) opens possibilities for combined therapies targeted to this protein set. PMID: 23603835
30. Data indicate that CD73 promoted metastasis through the activation of both A2A and A2B receptors. PMID: 23964122
31. Adenosine regulates bone metabolism via A1, A2A, and A2B receptors. PMID: 23682121
32. CD73 promotes the production of renal adenosine that is a prominent driver of renal hypertension by enhanced ADORA2B signaling-mediated endothelin-1 induction in a hypoxia-inducible factor-alpha-dependent manner. PMID: 23584256
33. Activation of Adenosine A2B receptors in cortical neurons induces leukemia inhibitory factor release. PMID: 22894638
34. Binding of A(2B)AR to specific sites on p105 prevents polyubiquitylation and degradation of p105 protein. PMID: 22767505
35. study identified the A2bAR as a significant regulator of HFD-induced hallmarks of T2D, thereby pointing to its therapeutic potential. PMID: 22848385
36. A2B adenosine receptor is upregulated in the peripheral lymphoid tissues of experimental autoimmune encephalomyelitis (EAE) mice. PMID: 23225885
37. T helper (Th)2-type cells demonstrate predominance for A2B receptor expression by myeloid cells as a mechanism of development of asthma-like pulmonary inflammation. PMID: 22956582
38. Distinct roles for hematopoietic cell A(2b) receptor in cell trafficking and for endothelial A(2b) receptor for microvascular permeability. PMID: 22707616
39. Study identified the A2BAR as a new regulator of osteoblast differentiation, bone formation, and fracture repair. PMID: 22403399
40. studies identify adenosine-elicited stabilization of Per2 in the control of HIF-dependent cardiac metabolism and ischemia tolerance and implicate Per2 stabilization PMID: 22504483
41. It is proposed that A2B adenosine receptor activation may be used by L. amazonensis to inhibit dendritic cell function and evade the immune response. PMID: 22311598
42. This studiy identified a novel regulator of sweet taste, the A2BR, which functions to potentiate sweet responses in posterior lingual taste fields. PMID: 22253866
43. the A(2b)AR regulates liver SREBP-1, hyperlipidemia, and atherosclerosis PMID: 22144568
44. The stimulatory effect of adenosine required primarily A(2B) receptors in activated macrophages. PMID: 21926236
45. Adora2b receptors are significantly associated with expression of the sweet taste receptor subunit Tas1r2. PMID: 22219293
46. blockade of A(2B)ARs enhances DC activation and CXCR3-dependent antitumor responses. PMID: 22116822
47. adenosine augmented IL-10 production by stimulating p38 MAPK. Collectively, our results establish that A(2B)ARs augment IL-10 production by activated murine microglia. PMID: 22116830
48. Both adenosine A(2A) and A(2B) receptors are required for adenosine A(1) receptor-mediated cardioprotection, implicating a role for interactions among receptor subtypes. PMID: 21743001
49. lowering adenosine in wild-type mice or genetic deletion of A(2B)R in mutant mice significantly attenuated PI3K/AKT activation, eNOS phosphorylation, and subsequent impaired penile erection PMID: 21566208
50. suggested a mechanism for putative proinflammatory effects of A(2B)AR PMID: 21593380

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KEGG: mmu:11541

STRING: 10090.ENSMUSP00000018644

UniGene: Mm.40740