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  4. Recombinant Mouse Amyloid-like protein 1 (Aplp1)

Recombinant Mouse Amyloid-like protein 1 (Aplp1)

  • 中文名称：
    Recombinant Mouse Amyloid-like protein 1(Aplp1)
  • 货号：
    CSB-CF001911MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Aplp1
  • Uniprot No.：
  • 别名：
    Aplp1; Amyloid beta precursor like protein 1; Amyloid beta; A4 precursor-like protein 1; Amyloid-like protein 1; APLP; APLP-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    38-653
  • 氨基酸序列
    NLAVGSPSAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCLLDPQRVLEYCRQMYPELHIARVEQAAQAIPMERWCGGTRSGRCAHPHHEVVPFHCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPATPNPSGMAAGDPSTRSWPLGGRAEGGEDEEEVESFPQPVDDYFVEPPQAEEEEEEEEERAPPPSSHTPVMVSRVTPTPRPTDGVDVYFGMPGEIGEHEGFLRAKMDLEERRMRQINEVMREWAMADSQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQGDPPQAERVLMALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVQTHLQVIEERMNQSLGLLDQNPHLAQELRPQIQELLLAEHLGPSELDASVPGSSSEDKGSLQPPESKDDPPVTLPKGSTDQESSSSGREKLTPLEQYEQKVNASAPRGFPFHSSDIQRDELAPSGTGVSREALSGLLIMGAGGGSLIVLSLLLLRKKKPYGTISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding. Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I.; The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis.
  • 基因功能参考文献：
    1. APLP1 exhibits synaptogenic activity, involving trans-synaptic dimerization. APLP1 knock-out mice show impaired basal transmission and a reduced mEPSC frequency. PMID: 28450540
    2. Results suggest that APLP1 deficiency on its own does not lead to defects in synaptic plasticity, but affects synaptic transmission and network inhibition in the dentate gyrus PMID: 25728909
    3. [review] A role of APP and its two closely related homologues APLP1 and APLP2 has been determined in various aspects of nervous system development and function, in particular, for synapse formation and function. PMID: 21931985
    4. findings demonstrated that NB-2 interacts with APLP and that both NB-2 and APLP1 are localized at presynaptic sites, suggesting that NB-2 associates with APLP1 in a cis manner on the presynaptic membrane PMID: 22285261
    5. Crystal structure of the E2 domain of amyloid precursor protein-like protein 1 in complex with sucrose octasulfate. PMID: 21715329
    6. The 5' UTR of the Aplp1 gene lacks any type of CAGA box. This may explain its inability to form amyloid plaques. PMID: 15208260
    7. Cytoplasmic polyadenylation element (CPE) binding factor binds the small intracellular domain (ICD) of APLP1. PMID: 16314516
    8. The results demonstrated that cell viability and neurite outgrowth of N2a cells undergoing knockdown of Aplp1 were significantly reduced, compared with N2a cells undergoing knockdown of either App or Aplp2. PMID: 16889988

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.; [C30]: Cytoplasm. Note=C-terminally processed in the Golgi complex.
  • 蛋白家族：
    APP family
  • 数据库链接：

    KEGG: mmu:11803

    STRING: 10090.ENSMUSP00000006828

    UniGene: Mm.2381