Recombinant Mouse Amyloid-like protein 2 (Aplp2)

1. APLP2 couples retina development and synaptic genes and present the first evidence that APLP2 expression may be linked to synaptic disease. PMID: 27267879
2. These data support the notion that APP and APLP2 facilitate transmitter release, likely through the interaction with the neurotransmitter release machinery. PMID: 26551565
3. This paper demonstrates an important role for APLP2 in refractive development in mice and humans, suggesting a high level of evolutionary conservation of the signaling pathways underlying refractive eye development. PMID: 26313004
4. Study provides compelling evidence for an essential role of both APP and APLP2 for neuronal and synaptic morphology as well as hippocampal function and suggest an acute and specific function of endogenous APPsalpha to facilitate synaptic plasticity PMID: 25432317
5. The study investigates the subcellular distribution patterns of the metal ions Cu, Zn, Fe, and Ca in individual neurons derived from APP and APLP2 knockout mice brains to further define their role in metal homeostasis. PMID: 25098278
6. This study further highlights the distinct and essential role of APLP2 at NMJ synapses that cannot be compensated by APP. PMID: 24998676
7. Amyloid precursor protein (APP)/APP-like protein 2 (APLP2) expression is required to initiate endosome-nucleus-autophagosome PMID: 24898256
8. The study investigated copper, iron, zinc and manganese levels in APP and APLP-2 single knockout mice as well as homozygous:hemizygous knockout mice at 3, 12 and 18 plus months of age. PMID: 24448592
9. Data reveal that APLP2 is specifically required for proper cell cycle exit of neuronal progenitors, and thus has a distinct role in priming cortical progenitors for neuronal differentiation. PMID: 23345401
10. APLP2 and the intracellular domain of APP are not essential for coherent activity patterns in the hippocampus, but have subtle effects on synaptic plasticity and fine-tuning of network oscillations. PMID: 23585881
11. Gain and loss of function experiments demonstrate that miR-153 suppresses expression of amyloid precursor protein (APP) and APLP2. PMID: 22510281
12. These studies highlight the so far underestimated functional importance of APLP2 for CNS physiology. PMID: 21931985
13. [review] Studies of protein expression in knock-out mice demonstrate that APP and APLP2 do indeed play an important role in synaptic plasticity. PMID: 22006270
14. APLP2 appears not to be essential for maintenance of dendritic structure, spine density, or synaptic function PMID: 22353605
15. proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and gamma-secretase PMID: 21695060
16. Collectively, these data show that APLP2 and APP are synergistically required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. PMID: 21522131
17. Data show there were no differences in expression were detectable between wt and floxed alleles. PMID: 20140888
18. role in inducing neuronal death is mediated by impairment of the neuroprotective calcium/calmodulin protein kinase IV-dependent signaling pathway PMID: 11877414
19. The levels of APLP2 proteolytic products were decreased in BACE KO mice, but increased in BACE transgenic mice. Overexpression of BACE in cultured cells led to increased APLP2 processing. PMID: 15080893
20. The APLP2 gene has both a GAGA sequence and a CAGA box immediately upstream of a position corresponding to the APP gene CAGA box. PMID: 15208260
21. These findings provide evidence for the role of amyloid-beta precursor protein in copper homeostasis and support the hypothesis that amyloid-beta precursor protein and amyloid precursor-like protein-2 are copper-binding proteins with interchangeable roles PMID: 15447675
22. Data describe a relationship between heparan sulfate and copper binding of amyloid precursor protein (APP) and amyloid precursor-like protein 2 (APLP2) in the modulation of nitroxyl anion-catalyzed heparan sulfate degradation in glypican-1. PMID: 15677459
23. Mice deficient in APlP2 exhibit aberrant apposition of presynaptic marker proteins with postsynaptic acetylcholine receptors and excessive nerve terminal sprouting. APLP2 is a key regulators of structure & function of developing neuromuscular synapses. PMID: 15689559
24. Occurrence of the YWK-II protein in the plasma membranes of mouse gametes suggests its involvement in sperm-egg interaction. PMID: 16177981
25. findings demonstrate that the APLP2-intracellular C-terminal domains interact with CP2 transcription factor in the nucleus and induce the expression of glycogen synthase kinase 3beta PMID: 16645641
26. specific domains of the extracellular region of YWK-II protein may be involved in sperm-egg interaction PMID: 16720320
27. The results demonstrated that cell viability and neurite outgrowth of N2a cells undergoing knockdown of Aplp1 were significantly reduced, compared with N2a cells undergoing knockdown of either App or Aplp2. PMID: 16889988
28. APLP2/MHC association is influenced by multiple domains of the MHC class I heavy chain and by beta(2)m's effects on the conformation of the heavy chain. PMID: 18452037
29. APP and amyloid precursor-like protein 2 (APLP2) have a significant role in the development of synaptic function by the regulation of glutamatergic neurotransmission PMID: 18535156
30. Amyloid precursor like protein-2 and amyloid beta protein precursor share overlapping anticoagulant functions with regard to regulating thrombosis after cerebral vascular injury. PMID: 19403832
31. APP and amyloid precursor-like protein 2 are expressed by stromal cells of thymus and lymph nodes, but not by lymphocytes. PMID: 19710207

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KEGG: mmu:11804

STRING: 10090.ENSMUSP00000072428

UniGene: Mm.19133