Recombinant Mouse B2 bradykinin receptor (Bdkrb2)

1. first evidence indicating the causation between ACE DD or B2R+9bp genotype and the increased risk for diabetic nephropathy, broadening our horizon about the role of genetic modulators in this disease. PMID: 28390948
2. B2R signaling promotes aortic rupture within a ApoE-eficient mouse model associated with the ability to stimulate inflammatory phenotypes of neutrophils and vascular smooth muscle cells. PMID: 26966276
3. B2R activation occurs in the diabetic skin and delays wound healing. B2R blockade improves skin wound healing in diabetic mice and is a potential therapeutic approach to diabetic ulcers. PMID: 26443866
4. role in nephrotoxicity induced by cisplatin therapy PMID: 24975837
5. a novel pathway by which C5aR/B2R cross-talk couples transendothelial leakage of plasma proteins to the cytokine circuitry that coordinates antiparasite immunity. PMID: 25187655
6. B(2) receptor deficiency altered plasma oxidant/antioxidant balance. PMID: 24020815
7. Data suggest that nicotine impairs mucosa-dependent Bdkrb2 (bradykinin B2 receptor) mediated trachea relaxation; nicotine also down-regulates tracheal expression of COX2/Ptgs2 (cyclooxygenase 2) and mPGES-1 (microsomal prostaglandin E2 synthase-1). PMID: 24380835
8. Data suggest that expression of Bdkrb2 is up-regulated in adrenal medulla as the result of immobilization stress; data from CRH (corticotropin-releasing hormone) knockout mice suggest this up-regulation requires catecholaminergic glucocorticoids. PMID: 24025224
9. Data indicate that Bdkrb2(-/-) mice have elevated plasma angiotensin-(1-7) and messenger RNA and protein for its receptor Mas. PMID: 23386129
10. Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney in mice. PMID: 23019230
11. Kinin-B2 receptor activity determines the differentiation fate of neural stem cells. PMID: 23132855
12. Data highlighted the role of several altered pathological pathways in response to disruption of B(2)R and to the diabetic state that included. PMID: 23028588
13. These findings suggest that activation of the bradykinin/B2R pathway contributes to development of host resistance to visceral leishmaniasis. PMID: 23151408
14. Data conclude that kinin B2 receptors are important for modulation of insulin secretion and for the preservation of normal glucose levels and hepatic functions in obese mice. PMID: 22829877
15. Signaling mediated by bradykinin B2 receptors contributes to mortality and secondary brain damage after subarachnoid hemorrhage in mice. PMID: 21242838
16. Role of vascular Kinin B2 receptors in endothelial nitric oxide metabolism PMID: 21704095
17. these data show that bradykinin receptor 2 plays a role in maintaining monosodium urate crystal-induced leukocyte infiltration and membrane permeability. PMID: 22079285
18. results indicate that the B2R is not essential for the exercise-induced decrements in blood glucose or plasma insulin or for the post-exercise increase in GU by insulin-stimulated mouse soleus muscle. PMID: 21401298
19. findings indicate that B(2)R plays a fundamental role in the regulation of cardiac function and Ca(2+) homeostasis, probably through a NO dependent pathway. PMID: 20970438
20. data provide the first evidence that specific integrins are involved in BK B(2) receptor-induced signaling in kidney cells, and ultimately might lead to development of new strategies for treatment of renal tubulointerstitial fibrosis PMID: 20385709
21. B2 receptor is apparently acting as a neuroprotective factor during aging. PMID: 20060587
22. our results show that kinin B(2) receptor deletion increases lean mass, reduces fat mass and improves metabolism efficiency in mice. PMID: 20045188
23. Bradykinin regulates the secretion and biosynthesis of ET-1 through kinin B(2) receptor in tumor cells, especially melanoma cells. PMID: 19969036
24. The present results show that bradykinin and its B(2) receptors play a causal role for brain edema formation and cell death after traumatic brain injury PMID: 19773800
25. NGF upregulates bradykinin B2 receptors in the surface membrane of DRG neurons upregulates bradykinin B2 receptor expression after nerve crush injury in vivo. PMID: 11860272
26. Increased vascular permeability in C1 inhibitor-deficient mice mediated by the bradykinin type 2 receptor. PMID: 11956243
27. results suggest that BK would promote angiogenesis by increasing vascular permeability in the early phase via B2 receptor in the endothelial cells and by promoting up-regulation of VEGF via B2 receptor in the stromal fibroblasts in the late phase PMID: 11962729
28. bradykinin B2 receptor activation reduces renal tubulointerstitial fibrosis PMID: 12163456
29. activates ERK1/2 in mIMCD-3 cells via transactivation of EGFR through a novel mechanism PMID: 12604671
30. s conclude that interaction of B2R signaling with other genetic determinants influences aging-related changes in myocardial structure and function, and findings may help understanding the role of kinins in the development of cardiac failure. PMID: 12654715
31. B2R(-/-)CRD mice exhibit permanent phenotypic and functional abnormalities in renal growth and differentiation. PMID: 12805091
32. B2R inactivation selectively worsens the maintenance phase of 2K1C Goldblatt hypertension and support the notion that B2R-deficient mice exhibit an impaired ability to release NO in response to elevations of ANG II levels. PMID: 12872048
33. The role of bradykinin B2-receptor in renal nitric oxide production. PMID: 12953015
34. Stimulation of AT2 receptors in the aorta by Ang II probably induces the generation of kinins. This in turn stimulates NO synthesis in the endothelium via the bradykinin B2-receptors, thereby enhancing cGMP production in the aorta. PMID: 15123575
35. EP24.15 associates with AT1 and B2 receptors both at the plasma membrane and after receptor internalization PMID: 15376229
36. B2R genotype can explain part of the baroreflex sensiticity variation that is unaccounted for by simple anthropometric variables and common risk factors. PMID: 15643126
37. B2BKR protein expression was below detection limits in nondifferentiated P19 cells but increased during the course of neuronal differentiation PMID: 15767251
38. Our results suggest a model whereby a seemingly silent genetic mutation of BdkrB2 predisposes mice to renal dysplasia by creating a "preapoptotic" state through p53 activation PMID: 16571598
39. absence of the bradykinin B2 receptor increases the oxidative stress, mitochondrial DNA damage, and many senescence-associated phenotypes already present in untreated Akita diabetic mice PMID: 16604193
40. Bradykinin B2 receptor is a modulator of antiparasite immunity. PMID: 17056563
41. Obligatory role of hypoxia in the angiogenic effect of angiotensin II in the mouse heart via the AT(2) receptor through a mechanism that involves bradykinin, its B2 receptor, and NO as a downstream effector. PMID: 17339539
42. BdkrB2 is a downstream target of the AT(1)R-CREB signaling pathway. PMID: 17344422
43. This significant increase in densities of kinin B(1) and B(2) receptors in animals submitted to Abeta infusion was observed mainly in brain regions related to cognitive behavior. PMID: 17570564
44. Discuss role of kinin B2 receptor in end stage renal disease. PMID: 17579666
45. Targeted deletion of B(2)-kinin receptors protects against the development of diabetic nephropathy. PMID: 17596525
46. Attenuation of postinfarct remodeling by overexpression of AT(2)R is not directly mediated via a B(2)R pathway. B(2)R may have a role in the smaller cavity size and hyperdynamic function and in limiting collagen deposition. PMID: 17933966
47. an important role for the kinin B2 receptor in physiological cardiac hypertrophy. PMID: 18182239
48. ACE/kinin B(2) receptor interaction modulates angiotensin-converting enzyme (ACE) activity. PMID: 18212275
49. plays a crucial role in angiogenesis that is induced by different vasoactive molecules, namely bradykinin, ACE inhibitors, B1-stimulating kinin metabolites, and VEGF164 in an in vitro model of angiogenesis of mouse heart under hypoxia PMID: 18566101
50. a possible explanation for the potency of bradykinin in inducing ongoing airway inflammation PMID: 18783336

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KEGG: mmu:12062

STRING: 10090.ENSMUSP00000001652

UniGene: Mm.390475