Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 跨膜蛋白
  4. Recombinant Mouse Bax inhibitor 1 (Tmbim6)

Recombinant Mouse Bax inhibitor 1 (Tmbim6)

  • 中文名称：
    小鼠Tmbim6重组蛋白
  • 货号：
    CSB-CF887505MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Tmbim6
  • Uniprot No.：
  • 别名：
    Tmbim6; Tegt; Bax inhibitor 1; BI-1; Testis-enhanced gene transcript protein; Transmembrane BAX inhibitor motif-containing protein 6
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-237
  • 氨基酸序列
    MNIFDRKINFDALLKFSHITPSTQQHLKKVYASFALCMFVAAAGAYVHVVTHFIQAGLLS ALGSLALMIWLMATPHSHETEQKRLGLLAGFAFLTGVGLGPALELCIAVNPSILPTAFMG TAMIFTCFSLSALYARRRSYLFLGGILMSAMSLMLLSSLGNLFFGSIWLFQANLYLGLLV MCGFVLFDTQLIIEKAEHGDKDYIWHCVDLFLDFVTLFRKLMLILAFNEKDKKKEKK
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Suppressor of apoptosis. Modulates unfolded protein response signaling. Modulates ER calcium homeostasis by acting as a calcium-leak channel. Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation.
  • 基因功能参考文献：
    1. BI-1 protects against obesity-induced hepatic insulin resistance by regulating CYP2E1 activity and reactive oxygen species production. PMID: 27576594
    2. BI-1-mediated enhancement of ApoB secretion regulates hepatic lipid accumulation. PMID: 27297735
    3. BI-1 has a major role in the functioning of the adaptive immune system by regulating intracellular Ca(2+) homeostasis in lymphocytes. PMID: 26470731
    4. An endogenous protective role of BI-1 under conditions of chronic mild stress. PMID: 24292328
    5. Results highlight the regulatory role of BI-1 in idiopathic pulmonary fibrosis. PMID: 24625972
    6. BI-1-induced ERK1/2 activation plays an important role in the modulation of intracellular reactive oxygen species generation and apoptotic cell death and may also affect autoimmune response. PMID: 22309999
    7. The results reveal BI-1 as a novel autophagy regulator that bridges Ca(2) signaling between ER and mitochondria, reducing cellular oxygen consumption and contributing to cellular resilience in the face of metabolic stress. PMID: 22588718
    8. BI-1-mediated enhancement of lysosomal activity regulates P450 2E1 expression and resultant ROS accumulation PMID: 22230367
    9. The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore. PMID: 22128171
    10. highly maintained lysosomal activity may be one of the mechanisms by which BI-1 exerts its regulatory effects on the ER stress response and cell death. PMID: 21586565
    11. A critical role of BI-1 as a stress integrator that modulates autophagy levels and other interconnected homeostatic processes. PMID: 21926971
    12. BI-1 reduces endoplasmic reticulum (ER) stress and provides protection from acute brain injury via modulation of several ER-associated functions, including unfolded protein response signaling. PMID: 21075086
    13. BI-1 may confer affective resiliency in multiple animal models of depression and anhedonia PMID: 21718971
    14. NleH effectors interact with Bax inhibitor-1 to block apoptosis during enteropathogenic Escherichia coli infection. PMID: 20133763
    15. Data show that BI-1 increased actin polymerization and cell adhesion through Ca2+ regulation and actin interaction. PMID: 20123969
    16. BI-1 is a critical regulator of ER stress responses in the development of obesity-associated insulin resistance PMID: 19996103
    17. BI-1 provides endogenous protection of liver and kidney from endoplasmic reticulum stress and ischemia-reperfusion injury. PMID: 16478805
    18. BI-1 and Bcl-X(L) operate downstream of or parallel to Bax/Bak PMID: 18299329
    19. Discusses cloning of rat testis enhanced gene transcript and identification of its homolog in mouse. PMID: 8012111
    20. Discusses cloning of human testis enhanced gene transcript and its conservation in mouse and rat. PMID: 8530040

    显示更多

    收起更多

  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    BI1 family
  • 组织特异性：
    Highly abundant in adult testis.
  • 数据库链接：

    KEGG: mmu:110213

    STRING: 10090.ENSMUSP00000023749

    UniGene: Mm.16769