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  4. Recombinant Mouse Beta-1 adrenergic receptor (Adrb1)

Recombinant Mouse Beta-1 adrenergic receptor (Adrb1)

Unavailable
  • 中文名称：
  • 货号：
    CSB-CF001391MO
  • 规格：
    ￥9720
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 别名：
    (Beta-1 adrenoreceptor)(Beta-1 adrenoceptor)
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length
  • 来源：
    in vitro E.coli expression system
  • 分子量：
    63.4 kDa
  • 表达区域：
    1-466aa
  • 氨基酸序列
    MGAGALALGASEPCNLSSAAPLPDGAATAARLLVLASPPASLLPPASEGSAPLSQQWTAGMGLLLALIVLLIVVGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARALVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPEPSPSPGPPRPADSLANGRSSKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDLVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAACRRRAAHGDRPRASGCLARAGPPPSPGAPSDDDDDDAGTTPPARLLEPWTGCNGGTTTVDSDSSLDEPGRQGFSSESKV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-SUMO-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling. Involved in the regulation of sleep/wake behaviors.
  • 基因功能参考文献：
    1. Cardiac specific expression of the mutated Cav1.2PKA_P2(-/-) gene reduces Cav1.2 alpha1c protein concentration, calcium current (ICa), and the beta-adrenergic stimulation of L-type ICa in cardiomyocytes. PMID: 28778765
    2. Proliferation in cardiac fibroblasts induced by beta1-adrenoceptor autoantibody results in endomyocardial fibrosis. PMID: 27577254
    3. the present study demonstrated that cardiac contractility/relaxation and heart rate is increased in beta1AR TG and beta2AR TG mice, and indicated that this increase may be related to the overexpression of G proteins and Gproteinassociated proteins. PMID: 28487987
    4. ghrelin has a critical role in preventing hypoglycemia and promoting survival during severe caloric restriction, a process that requires cell-expressed beta1AR PMID: 27548523
    5. knocking out of the beta1/2 receptor significantly diminished the ST25 acupuncture-induced inhibition of gastric motility and jejunal motility without significantly altering the enhancement of colonic motility induced by acupuncture at ST25. PMID: 27978539
    6. Computer simulations model the responses to moderate stimulation/inhibition of the beta1-adrenergic signaling system and its components in mouse ventricular myocytes. PMID: 26936457
    7. Our findings that BAG3 is localized at the sarcolemma and t-tubules while modulating myocyte contraction and action potential duration through specific interaction with the beta1-adrenergic receptor and L-type Ca(2+) channel provide novel insight into the role of BAG3 in cardiomyopathies and increased arrhythmia risks in heart failure. PMID: 26796036
    8. Galphai2 deficiency combined with cardiac beta1-adrenoceptor overexpression strongly impaired survival and cardiac function, leading to dilated cardiomyopathy. PMID: 26464333
    9. Knockout of the C5aR1 attenuated the effect of beta1-AR in the heart, suggesting an association between the beta1-AR and C5aR1, although further investigation is required to determine if this is a direct or causal association PMID: 26727203
    10. The beta1-AR may play an important role in the development of atrial fibrillation. PMID: 26203906
    11. Partial gap junction uncoupling increased propensity and amplitude of Ca(2+) alternans, and made them more sensitive to reversal by beta-AR activation, as in isolated myocytes. PMID: 25828762
    12. These data reveal a novel interplay between the E2F pathway, beta2-adrenergic/PKA/PDE4D, and ERK/c-Src axis in fine tuning the pathological hypertrophic growth response. PMID: 25944088
    13. Myocardial adrenergic receptor beta 1 preferentially associates with AC5. PMID: 25677623
    14. role of beta-ARs in early muscle regeneration PMID: 25000590
    15. Phosphorylation of beta1-AR by PKA stimulates active Ca(2+)influx through TRPV5. PMID: 24828496
    16. Sustained beta1-adrenoceptor activation in the diseased heart exacerbates left ventricular remodelling and therefore may promote disease progression from compensatory hypertrophy to heart failure PMID: 23750586
    17. This study report that both beta1- and beta2-ARs are expressed in a majority of GABAergic interneurons in the medial prefrontal cortex of mice. PMID: 24215978
    18. Calcium {Ca(2+)} entry through beta-adrenergic-stimulated LTCC underlies hypoxia-induced [Ca(2+)]i overload and the ensuing loss of mitochondrial function in intact heart. PMID: 24041537
    19. Data indicate that ischemic injury coupled to G protein-coupled receptor beta1/2 adrenergic receptors activation required GRK2 (GPCR kinase 2) activation. PMID: 24170934
    20. Our findings indicate a novel function for beta1AR-mediated beta-arrestin1 signaling activated by carvedilol in miR biogenesis. PMID: 24334028
    21. a significant role for the AKAP5 scaffold in signaling and trafficking of the beta1-AR in cardiac myocytes and mammalian cells. PMID: 24121510
    22. beta1-adrenergic receptor recycles via a membranous organelle, recycling endosome, by binding with sorting nexin27. PMID: 23780416
    23. We demonstrate that restoration of cardiac plasma membrane levels of S1PR1 produces beneficial effects that counterbalance the deleterious beta1AR overstimulation in heart failure. PMID: 23969695
    24. Canonical betaAR-mediated signaling coupled to PKA activation results in phosphorylation of spinophilin, disrupting its interaction with alpha2AARs and accelerating alpha2AAR endocytic responses. PMID: 23965992
    25. CREB-binding protein (CBP) regulates beta-adrenoceptor (beta-AR)-mediated apoptosis. PMID: 23579242
    26. TNFalpha-induced betaAR desensitization is mediated by GRK2 and is independent of Gbetagamma, uncovering a hitherto unknown cross-talk between TNFalpha and betaAR function, providing the underpinnings of inflammation-mediated cardiac dysfunction. PMID: 23785004
    27. Adrb1 activates Epac2 to induce sarcoplasmic reticulum calcium leakage via a pathway that contributes to arrhythmia and reduced cardiac function. PMID: 23363625
    28. In muscararinic M2 receptor knockout mice,heart function is not much affected; as possible mechanisms of this normal cardiac function, decreases of gene expression and receptor binding of beta1- and beta2-adrenoceptors should be considered PMID: 23093370
    29. A potential cooperative role for beta(1) and beta(2) adrenergic receptors in stress-induced reinstatement. PMID: 22593095
    30. The beta(1) signaling pathway mediates most of the sympathetic nervous system stimulation of adaptive thermogenesis. PMID: 22728333
    31. beta1- and beta2-adrenergic signaling exert opposite effects on bone- beta1 exerting a predominant anabolic stimulus in response to mechanical stimulation and during growth, whereas beta2-adrenergic receptor signaling mainly regulates bone resorption during aging. PMID: 22407956
    32. Data show that overexpression of beta1- and beta2-adrenergic receptors in hepatocytes from young mice and rats increased cellular lipid content. PMID: 22457517
    33. Norepinephrine regulates intestinal mucosal immune responses mediated by intestinal intraepithelial lymphocytes via beta adrenoreceptors. PMID: 22398028
    34. Induction of Fos by ssadrenergic signaling is critical for the full activation of CA1 pyramidal neurons in response to excitatory input from CA3 pyramidal neurons conveying retrieved contextual information. PMID: 21377513
    35. beta-Adrenergic receptor-PI3K signaling crosstalk in mouse heart PMID: 22028912
    36. Confinement of beta 1- and beta 2-adrenergic receptors in the plasma membrane of cardiomyocytes is mediated by selective interactions with PDZ domain and A-kinase anchoring proteins PMID: 21680711
    37. High (stress) levels of epinephrine directly compromise the activity of neonatal mouse skin fibroblasts through the activation of beta1-, beta2- and beta3-adrenoceptors, but not through alpha1- and alpha2-adrenoceptors. PMID: 21366703
    38. renin expression was found to be significantly lower at all developmental stages in the kidneys of adrenergic beta(1)/beta(2) knockout mice PMID: 21389089
    39. b1-adrenoceptors are the predominant b-adrenoceptor in mouse astrocytes and are primarily responsible for cAMP production in response to b-adrenoceptor stimulation PMID: 21138422
    40. negative inotropy and heart hypertrophy occur in total adrenergic beta receptor deficiency PMID: 20406048
    41. Results suggest that catecholamines induce myocyte necrosis primarily through beta(1)-AR-mediated increases in L-type calcium channel activity, but other mechanisms are also involved in rodents. PMID: 20495143
    42. the unique signaling effects of enhanced beta(2)AR and AC5, which have the potential to afford benefit in heart failure, failed to salvage ventricular function in beta(1)AR-mediated cardiomyopathy. PMID: 20443853
    43. beta-Adrenergic receptors transmit sympathetic signals to the ion secretory elements of the colonic epithelial cells stimulating a transient Cl ion secretion and a sustained K ion secretion. PMID: 20413718
    44. This work has provided insight into the intracellular signaling pathways and transcription factors regulating Ncx1 gene expression in a chronically beta-AR-stimulated heart. PMID: 19945464
    45. [beta]1-AR play a significant role in regulating LPS-mediated mortality and inflammation. PMID: 19333138
    46. vasoconstrictor role for vascular alpha1B-adrenoceptors in mouse PMID: 12006674
    47. Pathogenesis of DCM in CREB(A133) mice does not appear to involve abnormal betaAR signaling PMID: 12054854
    48. modulates receptor trafficking and signaling in cardiac myocytes PMID: 12097326
    49. betaAR signaling required for diet-induced thermogenesis and obesity resistance. PMID: 12161655
    50. role in obesity and cold sensitivity and response to fasting PMID: 12387862

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Early endosome.
  • 蛋白家族：
    G-protein coupled receptor 1 family, Adrenergic receptor subfamily, ADRB1 sub-subfamily
  • 组织特异性：
    In brain, expressed by glutamatergic and GABAergic neurons of the dorsal pons (at protein level).
  • 数据库链接：

    KEGG: mmu:11554

    STRING: 10090.ENSMUSP00000040847

    UniGene: Mm.46797