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  4. Recombinant Mouse Beta-2 adrenergic receptor (Adrb2)

Recombinant Mouse Beta-2 adrenergic receptor (Adrb2)

  • 货号：
    CSB-CF001392MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Adrb2; Adrb2r; Beta-2 adrenergic receptor; Beta-2 adrenoreceptor; Beta-2 adrenoceptor
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-418
  • 氨基酸序列
    MGPHGNDSDFLLAPNGSRAPDHDVTQERDEAWVVGMAILMSVIVLAIVFGNVLVITAIAK FERLQTVTNYFIISLACADLVMGLAVVPFGASHILMKMWNFGNFWCEFWTSIDVLCVTAS IETLCVIAVDRYVAITSPFKYQSLLTKNKARVVILMVWIVSGLTSFLPIQMHWYRATHKK AIDCYTEETCCDFFTNQAYAIASSIVSFYVPLVVMVFVYSRVFQVAKRQLQKIDKSEGRF HAQNLSQVEQDGRSGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIRD NLIPKEVYILLNWLGYVNSAFNPLIYCRSPDFRIAFQELLCLRRSSSKTYGNGYSSNSNG RTDYTGEPNTCQLGQEREQELLCEDPPGMEGFVNCQGTVPSLSVDSQGRNCSTNDSPL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
  • 基因功能参考文献：
    1. we identified the beta2 adrenergic receptor (ADRB2) as a downstream target for PHD3 in skeletal muscle PMID: 28939592
    2. Here, the mechanism by which norepinephrine (NE)regulates prostate cancer DTCs in the marrow is explored. NE directly stimulated prostate cancer cell proliferation through beta2-adrenergic receptors (ADRB2).. NE also altered prostate cancer proliferation in the marrow niche by indirectly downregulating the secretion of the dormancy inducing molecule growth arrest specific-6 (GAS6) expressed by osteoblasts. PMID: 28814453
    3. Adrenergic Receptor beta-2 signaling in the airway epithelium promotes eosinophilic inflammation, mucous metaplasia, and airway contractility. PMID: 29073113
    4. this review discusses beta2-adrenoceptor function in asthma PMID: 28950943
    5. the present study demonstrated that cardiac contractility/relaxation and heart rate is increased in beta1AR TG and beta2AR TG mice, and indicated that this increase may be related to the overexpression of G proteins and Gproteinassociated proteins. PMID: 28487987
    6. S1928A KI mice failed to induce long-term potentiation in response to prolonged theta-tetanus (PTT-LTP), a form of synaptic plasticity that requires Cav1.2 and enhancement of its activity by the beta2-adrenergic receptor (beta2AR)-cAMP-PKA cascade. PMID: 28119465
    7. activation of beta2AR decreased cerebral amyloid plaques through the up-regulation of alpha-secretase activity and by decreasing the phosphorylation of APP at Thr668 PMID: 27838449
    8. Together, these data indicate that high-fat diet promotes phosphorylation of the beta2 AR, contributing to impairment of cardiac contractile reserve before cardiac structural and functional remodelling, suggesting that early intervention in the insulin-adrenergic signalling network might be effective in prevention of cardiac complications in diabetes PMID: 27983752
    9. beta2-AR deletion is associated to selective hepatic insulin resistance and preserved skeletal muscle insulin sensitivity. PMID: 28684080
    10. The diurnal variation of the humoral immune response was dependent on beta2AR-mediated neural signals and was diminished when lymphocyte recirculation through lymph nodes was stopped. PMID: 27799619
    11. knocking out of the beta1/2 receptor significantly diminished the ST25 acupuncture-induced inhibition of gastric motility and jejunal motility without significantly altering the enhancement of colonic motility induced by acupuncture at ST25. PMID: 27978539
    12. The s show that phosphorylation of S1928 displaces the beta-2 adrenergic receptor from Cav1.2 upon beta-adrenergic stimulation rendering Cav1.2 refractory for several minutes from further beta-adrenergic stimulation. PMID: 27103070
    13. The Galphas and Galphaq peptides adopt different orientations in beta2-AR and V1AR, respectively. The beta2-AR/Galphas peptide interface is dominated by electrostatic interactions, whereas the V1AR/Galphaq peptide interactions are predominantly hydrophobic. PMID: 27330078
    14. Thus the beta2AR acts as a double-edged sword: increasing TAS2R14 cell surface expression, but when activated by beta-agonist, partially offsetting the expression phenotype by direct receptor:receptor desensitization of TAS2R14 function. PMID: 27342779
    15. Data show that inhibitory (Galphai2) and stimulatory (GalphasL) G-protein subunits produced minor atrophic and hypertrophic changes in muscle mass, and Galphai2 over-expression prevented AAV:beta2-adrenoceptor (beta2-AR) mediated hypertrophy. PMID: 26972746
    16. Age-related increase in hepatic triglyceride levels is reduced upon beta2-AR ablation. beta2-AR ablation improves glucose tolerance in old mice. PMID: 26952573
    17. Immune cell-expressed beta2AR plays an essential role in regulating the early inflammatory repair response to acute myocardial injury by facilitating cardiac leukocyte infiltration. PMID: 27364164
    18. In epileptic seizures mouse model, Pkdl deficiency leads to the loss of beta2AR on neuronal cilia, reduction in cAMP levels in the central nervous system, and reduction in the activation of cAMP response element-binding protein. PMID: 26612203
    19. Beta2AR overexpression enhances endothelial progenitor cells (EPC) functions in vitro and enhances the vascular repair abilities of EPCs in vivo via the beta2AR/Akt/eNOS pathway. PMID: 27194135
    20. Data show that beta2-AR plays an important role in prostate cancer metastasis formation. PMID: 26058426
    21. Inhibition of type 5 phosphodiesterase counteracts beta2-adrenergic signalling in beating cardiomyocytes. PMID: 25852085
    22. Housing temperature-induced stress drives therapeutic resistance in murine tumor models through beta2-adrenergic receptor activation. PMID: 25756236
    23. Quantification of beta adrenergic receptor subtypes in beta-arrestin knockout mouse airways. PMID: 25658948
    24. our results demonstrate that the beta2-adrenergic receptor is a key regulator of hepatic autophagy, and that the beta-blocker propranolol can independently induce a late block in autophagy. PMID: 24950230
    25. promotes the M2 macrophage phenotype in mouse models of endotoxemia and LPS-induced acute lung injury PMID: 24642449
    26. Lack of beta2 -adrenoceptors aggravates heart failure-induced skeletal muscle myopathy. PMID: 24629015
    27. This study demonstrated that TNFalpha plays a role in insulin resistance in beta2KO mice. PMID: 25138272
    28. Our results suggest that the beta2-adrenoceptor contributes to the regulation of the initial phases of muscle regeneration PMID: 24938737
    29. beta2AR-mediated signals inhibited lymph node egress of antigen-primed T cells and reduced their recruitment into peripheral tissues. PMID: 25422496
    30. role of beta-ARs in early muscle regeneration PMID: 25000590
    31. Adrenergic beta 2 receptor deficiency ameliorates tau pathology in a mouse model of tauopathies. PMID: 24626633
    32. Gene therapy or pharmacological means of increasing Galphas (or its coupling efficiency to beta2AR) thus represent an interface for development of novel therapeutic agents for improvement of beta-agonist therapy. PMID: 25260754
    33. Data indicate that adrenergic receptor beta2 activation modulates dendritic cells (DCs) function resulting in skewing towards anti-inflammatory T cell phenotypes. PMID: 24465481
    34. Beta-2-Adrenergic and M2-muscarinic receptors decrease basal t-tubular L-type calcium channel activity and suppress ventricular contractility in heart failure. PMID: 24389135
    35. These data indicate that increased insulin receptor signaling, may directly impair beta2-adrenergic receptor regulated cardiac contractility. PMID: 24677713
    36. specific interactions between the ligand and the Tyr-308 residue of beta2-AR stabilize receptor conformations favoring the receptor-Gs protein coupling and subsequently result in Gs-biased agonism. PMID: 24831005
    37. the cardio-protective effect of S-nitroso-N-acetylcysteine treatment is primarily through its anti-oxidant role and is associated with beta-ARs overexpression and beta-AR-SNO via an anti-apoptotic pathway PMID: 24333561
    38. The results of this study suggest that loss of beta2AR signalling results in a neuroprotective phenotype in part due to decreased NF-kappaB signalling, decreased inflammation and decreased apoptotic signalling in the brain. PMID: 22867428
    39. This study report that both beta1- and beta2-ARs are expressed in a majority of GABAergic interneurons in the medial prefrontal cortex of mice. PMID: 24215978
    40. Homotypic and heterotypic adhesion induced by odorant receptors and the beta2-adrenergic receptor. PMID: 24312457
    41. ADRB2 stimulation has caused a marked increase in the autophagy-targeted lipid droplets (LD) for lysosomal degradation, which is dependent on the LD-associated RAB7. PMID: 23708524
    42. Data indicate that adrenergic receptor beta2 knockout (ARbeta2KO) mice preserved cold- and diet-induced adaptive thermogenesis but disrupts glucose homeostasis. PMID: 24868110
    43. Disruption of gravin's scaffold mediated signaling is able to increase baseline cardiac function as well as to augment contractility in response to acute beta-AR stimulation. PMID: 24058627
    44. Data indicate that ischemic injury coupled to G protein-coupled receptor beta1/2 adrenergic receptors activation required GRK2 (GPCR kinase 2) activation. PMID: 24170934
    45. Deletion of the beta2-adrenergic receptor prevents the development of cardiomyopathy in mice. PMID: 23920331
    46. We demonstrate that beta2-adrenergic receptor-dependent activation of proinflammatory macrophages is critical for epinephrine-mediated IL-6 production in wound healing. PMID: 24121404
    47. the beta2-AR-HIF-1alpha axis regulates stress-induced pancreatic tumor growth and angiogenesis. PMID: 23745588
    48. GRK2 blockade with betaARKct is essential for cardiac beta2-adrenergic receptor signaling towards increased contractility. PMID: 23984976
    49. beta2-adrenergic receptor knockout mice exhibit A diabetic retinopathy phenotype. PMID: 23894672
    50. expression and function of beta(3)-adrenoceptors and beta(2)-adrenoceptors in mouse uterus PMID: 23219791

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Early endosome. Golgi apparatus.
  • 蛋白家族：
    G-protein coupled receptor 1 family, Adrenergic receptor subfamily, ADRB2 sub-subfamily
  • 数据库链接：

    KEGG: mmu:11555

    STRING: 10090.ENSMUSP00000062256

    UniGene: Mm.5598