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  4. Recombinant Mouse Bombesin receptor subtype-3 (Brs3)

Recombinant Mouse Bombesin receptor subtype-3 (Brs3)

  • 货号：
    CSB-CF002820MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Brs3; Bombesin receptor subtype-3; BRS-3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-399
  • 氨基酸序列
    MSQRQSQSPNQTLISITNDTETSSSVVSNDTTHKGWTGDNSPGIEALCAIYITYAGIISV GILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGKVGC KVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPPNAILKTCAKAGGIWIVSMIFAL PEAIFSNVYTFQDPNRNVTFESCNSYPISERLLQEIHSLLCFLVFYIIPLSIISVYYSLI ARTLYKSTLNIPTEEQSHARKQIESRKRIAKTVLVLVALFALCWLPNHLLYLYHSFTYES YANHSDVPFVIIIFSRVLAFSNSCVNPFALYWLSKTFQQHFKAQLCCLKAEQPEPPLGDI PLNNLTVMGRVPATGSAHVSEISVTLFSGSSAKKGEDKV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
  • 基因功能参考文献：
    1. Data suggest that the failure to detect an existing endogenous bombesin-like receptor 3 (BRS-3) ligand in the parabiotic mice could be due to limited cross-circulation and a ligand's short half-life. PMID: 26562312
    2. Data show that gastrin-releasing peptide receptor/bombesin receptor subtype-3 positive cells and protein expression in tumors decreased by treatment with RC-3095 or gemcitabine alone or greater in combination. PMID: 24326363
    3. Data from knockout mice suggest that Brs3 involvement in regulation of body temperature is via a central mechanism, upstream of sympathetic efferent pathways to stimulate brown adipose tissue. PMID: 24452453
    4. This sstudy demonistrated comprehensive mapping of BRS-3 mRNA in the mouse brain and double in situ hybridization was performed to determine whether BRS-3 colocalizes with other neurotransmitters or neuropeptides. PMID: 22911445
    5. Data suggest that the bombesin receptor subtype-3 agonist indirectly inhibited orexin neurons through GABAergic input and directly activated orexin neurons. PMID: 20467915
    6. BRS-3-deficient mice remained longer in the open arms of the maze. Analyses of risk assessment behavior revealed that BRS-3-deficient mice exhibited increased 'stretched attend posture' behavior in both the L-D box and elevated plus maze tests. PMID: 11803457
    7. BRS-3 genes were expressed from embryonic days 13-16 and on multiple postnatal days for lungs PMID: 12959933
    8. BRS-3 gene deletion upsets the mechanism by which leptin decreases the expression of MCH-R. PMID: 14988239
    9. Hyperphagia is a major factor leading to increased body weight and hyperinsulinemia in BRS-3 KO mice. PMID: 18039774

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 数据库链接：

    KEGG: mmu:12209

    STRING: 10090.ENSMUSP00000033464

    UniGene: Mm.10687