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  4. Recombinant Mouse Bone morphogenetic protein receptor type-1B (Bmpr1b)

Recombinant Mouse Bone morphogenetic protein receptor type-1B (Bmpr1b)

  • 货号：
    CSB-CF002751MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Bmpr1b; Acvrlk6; Bone morphogenetic protein receptor type-1B; BMP type-1B receptor; BMPR-1B; Activin receptor-like kinase 6; ALK-6; Serine/threonine-protein kinase receptor R6; SKR6; CD antigen CDw293
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    14-502
  • 氨基酸序列
    KKEDGESTAPTPRPKILRCKCHHHCPEDSVNNICSTDGYCFTMIEEDDSGMPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKDRDFVDGPIHHKALLISVTVCSLLLVLIILFCYFRYKRQEARPRYSIGLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEIARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCMKKLRPSFPNRWSSDECLRQMGKLMTECWAQNPASRLTALRVKKTLAKMSESQDIKL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1. Receptor for GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction.
  • 基因功能参考文献：
    1. Study concludes that growth/differentiation factor-5 (GDF-5) protects hippocampal neurons against kainic acid-induced neurodegeneration by signaling through bone morphogenetic protein receptor type IB, suggesting a therapeutic potential for GDF-5 in neurodegenerative diseases. PMID: 28458020
    2. dermal BMPRIB+ cells possessed a similar osteogenic differentiation potential with BMSCs in a mouse model. Dermal BMPRIB+ subpopulations possessed low immunogenicity and immunosuppressive properties before and after osteogenic differentiation. PMID: 27552226
    3. BMPR1B plays distinct roles from BMPR1A and ACVR1 in maintaining bone mass and transducing BMP signaling PMID: 27048979
    4. Local administration of adenovirus expressing siRNA-targeting BMPR-IB may be a feasible and effective therapeutic candidate to treat or prevent wear debris-associated osteolysis. PMID: 22827452
    5. Type Ib BMP receptors mediate the rate of commissural axon extension through inhibition of cofilin activity PMID: 23250207
    6. the BMP-2-BMPR-IB-ODAM-MAPK signaling cascade has important roles in ameloblast differentiation and enamel mineralization PMID: 22213140
    7. Variation in BMPR1B is associated with dizygotic twinning. PMID: 21962132
    8. results indicate a requirement for BMP signaling in generating the dorsalmost neuronal lineage of the telencephalon, DG granule neurons, and in the development of the stem cell niche that makes neurons in the adult hippocampus. PMID: 20445055
    9. TbetaRIII enhanced ALK6-mediated stimulation of the BMP-responsive promoters XVent2 & 3GC2, & up-regulation of the early-response gene Smad6. Interaction with ALK6 required both the extracellular & cytoplasmic domains. PMID: 19726563
    10. effects of loss of one of the BMP receptors, the BmprIb, on the development of the eye by using targeted deletion PMID: 12654290
    11. signaling through bone morphogenetic protein (BMP) type 1 receptors is required for the formation of two populations of commissural neurons, DI1 and DI2 PMID: 15469980
    12. Data demonstrate that the osteogenic commitment of multipotent mouse adipose-derived adult stromal cells requires retinoic acid, which enhances expression of the critical bone morphogenetic protein receptor-IB isoform. PMID: 16894153
    13. HGF up-regulates the expression of the bone morphogenetic protein receptors, BMPR-IB and BMPR-II, in prostate cancer cells PMID: 17203235
    14. the combination of constitutively active activin receptor-like kinase 6 (caALK6) and Runx2 efficiently induced osteogenic differentiation in various cell types, including terminally differentiated nonosteogenic cells PMID: 17317722
    15. Expression of BMP receptors Ib and II, and Smads 4, 5, 6, and 8, was downregulated in lungs but not kidneys of MCT-treated rats. PMID: 17347486
    16. BMPRs-Ib, -II, the activin receptor-1 (ActR-1) and the phosphorylated Smad1 were detected in DF and HERS at D6 and later more diffusely in the periodontium. BMPR-Ia detection was restricted to alveolar bone. PMID: 17662325
    17. crystals consisted of the full ternary complex GDF5-BRIB-ActRIIB, but only diffracted to low resolution PMID: 19652338

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  • 亚细胞定位：
    Cell membrane. Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
  • 数据库链接：

    KEGG: mmu:12167

    STRING: 10090.ENSMUSP00000029948

    UniGene: Mm.39089