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  4. Recombinant Mouse Brain protein 44 (Brp44)

Recombinant Mouse Brain protein 44 (Brp44)

  • 货号：
    CSB-CF002816MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Mpc2
  • Uniprot No.：
  • 别名：
    Mpc2; Brp44; Mitochondrial pyruvate carrier 2; Brain protein 44
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-127
  • 氨基酸序列
    MAAAGARGLRATYHRLMDKVELLLPKKLRPLYNHPAGPRTVFFWAPIMKWGLVCAGLADM ARPAEKLSTAQSTVLMATGFIWSRYSLVIIPKNWSLFAVNFFVGSAGASQLFRIWRYNQE LKSKGIQ
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Mediates the uptake of pyruvate into mitochondria.
  • 基因功能参考文献：
    1. Inhibition of pyruvate metabolism by tolylfluanid required MPC2. PMID: 29126303
    2. The interaction between TZDs and MPC2 is not affected by loss of the N-terminal 16 amino acid. PMID: 28597936
    3. MPC2 acetylation is increased in Diabetic Heart mitochondria. This study supports the conclusion that deficient pyruvate transport activity, mediated in part by acetylation of MPC2, is a contributor to metabolic inflexibility in the diabetic heart. PMID: 28154187
    4. Oxidative glutaminolysis supports the TCA cycle in mouse cells lacking MPC1/2. PMID: 25458843
  • 亚细胞定位：
    Mitochondrion inner membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family
  • 数据库链接：

    KEGG: mmu:70456

    STRING: 10090.ENSMUSP00000027853

    UniGene: Mm.195625